Marianna AMBONI | Progetti

The main hypothesis underlying the present study is that, due to the several and poorly understood factors associated with freezing of Gait (FOG) in Parkinson Disease (PD), using and integrating multiple quantitative gait information may help in better defining the gait phenotype associated with a mild form of FOG. The main aim is contributing to the early identification of such phenomenon in

1) To compare the spatio-temporal gait parameters among Mild Cognitive Impairment (MCI), Subjective Cognitive Impairment (SCI) and cognitively unimpaired Parkinson Disease (PD) patients in three different gait settings, i.e. a single-task and two different dual tasks; 2) To find specific gait patterns that could be objective markers of the self-reported symptoms-based construct of SCI in PD.

1. To evaluate the efficacy of vortioxetine in improving depressive symptoms and cognitive dysfunction in patients with Parkinson Disease2. To assess the efficacy of vortioxetine in reducing moderate/severe FOG not responsive to dopaminergic treatment in patients with Parkinson Disease and depressive symptoms

1. Implementare valutazioni multiparametriche longitudinali per una migliore definizione fenotipica dell'idrocefalo normoteso, con particolare riguardo a: studio quantitativo del cammino nelle prove di single e dual task motoria e cognitiva e con l'aiuto di cues visivi ed uditivi; valutazione neuropsicologica; valutazione della funzione urinaria con scale validate ed esami strumentali; questionari