TANIA CIAGLIA | Curriculum

Dr Tania Ciaglia acquired her Master Degree in medicinal chemistry at the University of Salerno on the 14/02/2014, with a thesis titled “Design, synthesis and biological evaluation on novel GRK2 inhibitors’’. She acquired her PhD in Pharmaceutical sciences at the Department of Pharmacy, University of Salerno, on the 28/03/2018, with a thesis titled “Design and synthesis of bioactive small molecules by traditional and innovative methods ". During her PhD course she spent a research period at the Kappe Laboratories, Karl-Franzens’ University in Graz, gaining new insights about flow chemistry applications for the obtainment of pharmacologically active compounds. During the period she spent at the University of Salerno, Dr Tania Ciaglia’s activity focused on drug discovery and drug development, with particular attention to the synthesis of heterocyclic small molecules, peptides and peptidomimetic derivatives, using batch, flow (Vapourtec E-series) and microwave assisted (Monowave 300 Anton-Paar, Initiator +, Biotage) procedures. Moreover, she acquired knowledge about several chromatographic techniques including TLC, PLC, HPLC and flash chromatography and on the characterization of the synthetised compounds by mass spectrometry (Waters Q-TOF premiere, Maldi-TOF Bruker) and Nuclear Magnetic Resonance (Bruker 300 MHz, Bruker 400 MHz, Bruker 500 MHz). The main fields of her research activity focus on the synthesis of small molecules as ion channels modulators, including TRPM8 and Kv7, which results mainly involved in epileptic conditions, the design and synthesis of novel anti-inflammatory compounds, active against the enzymes of the arachidonic acid metabolic cascade, such as 5-LOX and sEH; her activity concerns also the synthesis of antiviral agents, acting as Varicella Zoster Virus (VZV) and SARS-COV-2 proteases inhibitors, novel reaction mechanisms including the optimization of oxidative cyclization reactions based on tetra-hydrobetacarboline scaffolds and ultrasound-mediated heterocyclic compounds amino-methylation. In 2023 she won a Research position in Medicinal Chemistry (SSD CHIM08) at the Department of Pharmacy of the University of Salerno.