Maria VIVO | GENETICS
Maria VIVO GENETICS
cod. 0512800036
GENETICS
| 0512800036 | |
| DEPARTMENT OF CHEMISTRY AND BIOLOGY "ADOLFO ZAMBELLI" | |
| EQF6 | |
| BIOLOGICAL SCIENCES | |
| 2020/2021 |
| OBBLIGATORIO | |
| YEAR OF COURSE 3 | |
| YEAR OF DIDACTIC SYSTEM 2016 | |
| PRIMO SEMESTRE |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| BIO/18 | 8 | 64 | LESSONS |
| Objectives | |
|---|---|
| ACQUISITION OF BASIC PRINCIPLES OF GENETICS THROUGH THE CONCEPTS OF FORMAL MOLECULAR AND POPULATIONS GENETICS. ACQUISITION OF COMPETENCE OF BIOLOGY AND GENETICS OF LIVING BODIES. MOLECULAR EVOLUTION AND MECHANISMS OF INHERITANCE. UNDERSTANDING OF MECHANISMS OF ORGANIZATION, DEVELOPMENT AND EXPRESSION OF GENES AND GENOME. |
| Prerequisites | |
|---|---|
| STUDENTS SHOULD HAVE SUCCESSFULLY PASSED THE EXAMS OF CYTOLOGY AND HISTOLOGY AND MOLECULAR BIOLOGY. IT IS RECOMMENDED FOR A BETTER UNDERSTANDING OF GENETICS THAT A DEEP AND REVISED BASIC KNOWLEDGE OF BIOLOGY AND CYTOLOGY (CHROMOSOMES-CHROMATIDS-MITOTIC SPINDLE-CELL DIVISION- MITOSIS AND MEIOSIS). |
| Contents | |
|---|---|
| MENDELIAN ANALYSIS (8H FRONT LESSON) GENETIC MEANING OF MITOSIS AND MEIOSIS; MENDEL'S LAWS; THE GENOTYPE AND THE PHENOTYPE; COMPLETE, INCOMPLETE DOMINANCE AND CODOMINANCE; LETHAL ALLELES; MULTIPLE ALLELES. THE CHROMOSOMAL THEORY OF GENES AND CHROMOSOMES INHERITANCE (4H FRONT LESSON). SEX-RELATED INHERITANCE; MECHANISMS OF GENETIC SEX DETERMINATION; MENDELIAN CHARACTERS IN HUMANS AND THE ANALYSIS OF FAMILY TREES. EXTENSION OF MENDELIAN ANALYSIS (2H FRONT LESSON): PLEIOTROPY; PENETRANCE AND EXPRESSIVENESS; INTERACTIONS BETWEEN GENES; GENETIC COMPLEMENTATION; NOTES ON QUANTITATIVE TRAITS GENETIC MAPS IN EUKARYOTES (6H FRONT LESSON) ASSOCIATION; GENETIC RECOMBINATION; CROSSING-OVER; GENETIC MAPS. RECOMBINATION ANALYSIS IN HAPLOID ORGANISMS; ANALYSIS OF TETRADS; GENE CONVERSION AND HOLLIDAY'S MODEL OF CROSSING-OVER; MITOTIC CROSSING-OVER. GENETIC MAPS IN BACTERIA AND BACTERIOPHAGES (6H FRONT LESSON) GENETIC MAPS IN BACTERIA: TRANSFORMATION, CONJUGATION, TRANSDUCTION; STRUCTURE AND FUNCTION OF THE GENE (20H FRONT LESSON) THE HYPOTHESIS A GENE-AN ENZYME; BENZER EXPERIMENTS; THE FINE STRUCTURE OF THE GENE; THE GENETIC CODE; GENE-PROTEIN COLINEARITY. GENOME ORGANIZATION: GENES AND CHROMOSOMES DNA AND RNA AS HEREDITARY MATERIAL; SEMI-CONSERVATIVE DNA DUPLICATION. PRODUCTION MECHANISMS OF GENETIC VARIABILITY (4H FRONT LESSON): GENE MUTATIONS DEFINITION AND CLASSIFICATION OF MUTATIONS. FLUCTUATION TEST. INTRAGENIC AND INTERGENIC REVERSE MUTATION AND SUPPRESSION; SPONTANEOUS MUTATIONS. PHYSICAL AND CHEMICAL MUTAGENS AND INDUCED MOLECULAR DAMAGE. MUTAGENESIS TESTS. DNA REPAIR MECHANISMS. CHROMOSOMAL MUTATIONS CHROMOSOMAL ABERRATIONS. ANEUPLOIDIES, MONOPLOIDS AND POLYPLOIDS. CAUSES AND CONSEQUENCES OF CHROMOSOMAL REARRANGEMENTS. EFFECTS OF REARRANGEMENTS ON GENE EXPRESSION. INACTIVATION OF THE X CHROMOSOME, DOSAGE COMPENSATION. MOSAICISM. REGULATION OF GENE EXPRESSION IN PROKARYOTES (4H FRONT LESSON) UNDERLYING MECHANISMS OF GENE EXPRESSION IN BACTERIA. ELEMENTS OF CONTROL OF TRANSCRIPTION IN PROKARYOTES, POSITIVE AND NEGATIVE REGULATION OF TRANSCRIPTION, OPERONS, THE MODEL OF ATTENUATION. JACOB AND MONOD EXPERIMENTS. REGULATION OF GENE EXPRESSION IN EUKARYOTES (6H FRONT LESSON) ELEMENTS OF TRANSCRIPTION CONTROL AND POSITIVE AND NEGATIVE REGULATION OF TRANSCRIPTION IN EUKARYOTES. TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL REGULATION. REGULATION OF GENE EXPRESSION THROUGH ALTERNATIVE SPLICING. ROLE OF SPLICING REGULATION DURING GENE TRANSCRIPTION. THE MODEL OF TRANSCRIPTION FACTORIES. ROLE OF CHROMATIN. INACTIVATION OF THE X CHROMOSOME AND DOSAGE COMPENSATION. EPIGENETIC REGULATION MECHANISMS: HISTONE MODIFICATION, THE THREE-DIMENSIONAL STRUCTURE OF CHROMATIN AND NUCLEAR STRUCTURE. INTRODUCTION TO GENE TRANSCRIPTION REGULATION DURING EMBRYONIC DEVELOPMENT. EXTRANUCLEAR INHERITANCE (2H FRONT LESSON) NOTES ON: THE GENOME OF MITOCHONDRIA AND PLASTIDS. CYTOPLASMIC INHERITANCE. MATERNAL EFFECT. POPULATION GENETICS (2H FRONT LESSON) HARDY-WEINBERG'S LAW AND ITS APPLICATIONS. POLYMORPHISMS. EVOLUTIONARY MECHANISMS: MUTATION; MIGRATION; GENETIC DRIFT; NATURAL SELECTION AND FITNESS. |
| Teaching Methods | |
|---|---|
| THE COURSE IS ORGANIZED IN TWO HOURS LECTURES FOR A TOTAL OF 8 CFU, AIMED TO THE DEVELOPMENT OF CRITICAL SKILLS THROUGH THE STUDY OF THE EVOLUTION OF THE CONCEPT OF THE GENE THROUGH OBSERVATION, INTEGRATION OF PHENOTYPE, EXPERIMENTAL EVIDENCE AND ANALYSIS OF DATA IN A LOGICAL FASHION. THE COURSE INCLUDES THEORETICAL LESSONS, EXERCISES, SEMINARS, INTERACTION WITH THE TEACHER AND WITH EXPERTS IN THE SECTOR. DURING THE PRACTICES, THE STUDENT WILL FACE TASKS THAT INVOLVE CROSSINGS TO IDENTIFY THE GENOTYPE OR THE TRANSMISSION MODE OF ONE OR MORE CHARACTERS. THE RESOLUTION METHOD CONSISTS OF OBSERVING AND COLLECTING DATA, PLANNING THE WORKING HYPOTHESIS, AND FINALLY, RESOLUTION. THIS LAST PHASE PROMOTES THE ABILITY TO ASSESS THE REASONABLENESS OF THE RESPONSE AND TO VERIFY CONSISTENCY WITH THE FUNDAMENTAL PRINCIPLES OF GENETICS AND BIOLOGY. |
| Verification of learning | |
|---|---|
| THE FINAL EXAM TEST AIMS AT ASSESSING THE KNOWLEDGE OF THE FUNDAMENTAL PRINCIPLES OF GENETICS AND THE POSSIBILITY OF RECOGNIZING HOW ONE OR MORE CHARACTERS ARE TRANSMITTED. IT CONSISTS OF A WRITTEN TEST PREPARATORY TO AN ORAL INTERVIEW. THE WRITTEN TEST TO BE CARRIED OUT IN 90 MINUTES CONSISTS OF FORMAL AND POPULATION GENETIC EXERCISES, SUCH AS IDENTIFICATION OF A GENOTYPE BASED ON THE ANALYSIS OF A PROGENY, THE FORMULATION OF A GENETIC MAP, IDENTIFICATION OF THE TRANSMISSION MODE OF HUMAN SYNDROMES THROUGH THE STUDY OF THE GENEALOGICAL TREE, THE EVALUATION OF THE EQUILIBRIUM STATE OF A POPULATION, AS WELL AS QUESTIONS CONCERNING THE MECHANISMS OF DNA REPLICATION, GENE EXPRESSION, USE OF VARIOUS MODEL SYSTEMS FOR GENETIC ANALYSIS. THE ORAL EXAM WILL BE AIMED AT FILLING ANY GAPS FOUND IN THE WRITTEN TEST, AND AT VERIFYING THE LEVEL OF KNOWLEDGE OF THE THEORETICAL BASES THAT REGULATE THE INDICATED MECHANISMS. THE FINAL MARK, EXPRESSED IN THIRTIETHS WITH POSSIBLE HONOURS, WILL DEPEND ON THE OVERALL MATURITY ACQUIRED ON THE COURSE CONTENT. THE FOLLOWING FEATURES WILL BE TAKEN INTO ACCOUNT: • THE QUALITY OF THE EXHIBITION, IN TERMS OF USING APPROPRIATE SCIENTIFIC LANGUAGE • THE ABILITY OF CROSS-CORRELATION BETWEEN THE DIFFERENT TOPICS OF THE COURSE AND, WHERE POSSIBLE, WITH OTHERS DISCIPLINES • OF THE INDEPENDENCE OF JUDGMENT DEMONSTRATED THE STUDENT REACHES THE LEVEL OF EXCELLENCE IF HE PROVES TO BE ABLE TO FACE PROBLEMS (EVEN UNUSUAL OR NOT EXPRESSLY TREATED IN CLASS), MAKING ORIGINAL OBSERVATIONS, AND DEMONSTRATING DEDUCTION AND CORRELATION SKILLS, WITH THE VERIFICATION OF THE HYPOTHESES MADE. |
| Texts | |
|---|---|
| GENETICA – DALL’ANALISI FORMALE ALLA GENOMICA. HARTWELL – HOOD-GOLDBERG-REYNOLDS- SILVER-VERES. ED. MCGRAW-HILL GENETICA MODERNA. GRIFFITHS, A.J.F. -MILLER,J.H.-GELBART, W.M.-LEWONTIN, R. C. ED. ZANICHELLI PRINCIPI DI GENETICA. SNUSTAD-SIMMONS. ED. EDISES GENETICA. RUSSEL P.J. ED. EDISES GENETICA. PIERCE B. A. ED ZANICHELLI GENETICA ANALISI E PRINCIPI. ROBERT J. BROOKER. ED. ZANICHELLI GENETICA – ANALISI DI GENI E GENOMI. HARTL – JONES. ED. EDISES |
| More Information | |
|---|---|
| FURTHER EXPLANATIONS AND METHODOLOGICAL SUPPORT WILL BE PROVIDED TO THE STUDENTS DURING THE RECEPTION HOURS. DAYS, TIMES AND PLACE OF RECEPTION, AS WELL AS ANY CHANGES, ARE COMMUNICATED TO THE FOLLOWING LINK: HTTPS://DOCENTI.UNISA.IT/031897/HOME FURTHERMORE, IT IS POSSIBLE TO ARRANGE AN APPOINTMENT OUTSIDE THE SCHEDULED RECEPTION TIMES BY SENDING AN EMAIL TO THE ADDRESS MVIVO@UNISA.IT |
BETA VERSION Data source ESSE3 [Ultima Sincronizzazione: 2022-05-23]
