JESSICA DAL COL | General Pathology and Microbiology

cod. 1012400007

GENERAL PATHOLOGY AND MICROBIOLOGY

	1012400007
	DEPARTMENT OF MEDICINE, SURGERY AND DENTISTRY "SALERNITANA MEDICAL SCHOOL"
	EQF6
	MIDWIFERY
	2024/2025

PERCORSO STUDY PATHWAY IN COMMON IN OBSTETRICS

	OBBLIGATORIO
	YEAR OF COURSE 1
	YEAR OF DIDACTIC SYSTEM 2013
	SPRING SEMESTER

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	PATOLOGIA GENERALE E MICROBIOLOGIA - MOD. PATOLOGIA GENERALE
	MED/04	2	24	LESSONS	BASIC COMPULSORY SUBJECTS
2	PATOLOGIA GENERALE E MICROBIOLOGIA - MOD. PATOLOGIA CLINICA
	MED/05	1	12	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
3	PATOLOGIA GENERALE E MICROBIOLOGIA - MOD. MICROBIOLOGIA E MICROBIOLOGIA CLINICA
	MED/07	1	12	LESSONS	BASIC COMPULSORY SUBJECTS
4	PATOLOGIA GENERALE E MICROBIOLOGIA - MOD. MEDICINA DI LABORATORIO
	MED/46	2	24	LESSONS	SUPPLEMENTARY COMPULSORY SUBJECTS

PROFESSORS

	VIVIANA IZZO4 T Curriculum
	ROBERTA TARALLO1 Curriculum
	JESSICA DAL COL2 Curriculum
	GIANLUIGI FRANCI3 Curriculum

EXAMS

	Exam	Date	Session
	PATOLOGIA GENERALE E MICROBIOLOGIA	04/07/2025 - 09:00	SESSIONE ORDINARIA
	PATOLOGIA GENERALE E MICROBIOLOGIA	24/07/2025 - 09:00	SESSIONE ORDINARIA

	Objectives
	THE LESSONS WILL PROVIDE STUDENTS WITH THE ELEMENTS TO STUDY THE MECHANISMS UNDERLYING THE DISEASE PHENOMENON. IN PARTICULAR, THE AETIOLOGY, PATHOGENESIS AND BIOLOGICAL AND MOLECULAR BASES WITH WHICH DISEASES, INFECTIOUS AND OTHERWISE, PRODUCE SPECIFIC SIGNS OR SYMPTOMS WILL BE EXPLORED. KNOWLEDGE AND UNDERSTANDING AT THE END OF THE COURSE, STUDENTS WILL KNOW AND UNDERSTAND: - THE BIOLOGICAL PHENOMENA OF THE MAIN MECHANISMS OF FUNCTIONING OF ORGANS AND SYSTEMS, SPECIFICALLY THE PHYSIOLOGY OF HUMAN REPRODUCTION AND EMBRYONIC DEVELOPMENT; - THE PHYSIOPATHOLOGY OF THE REPRODUCTIVE SYSTEM AND ITS ENDOCRINE AND METABOLIC REGULATION, IN THE VARIOUS STAGES OF A WOMAN'S LIFE, AIMED AT BUILDING THE SPECIFIC SKILLS OF THE PROFESSIONAL PROFILE OF THE MIDWIFE; - THE FUNDAMENTALS OF MICROBIOLOGY IN ORDER TO RECOGNIZE THE BIOLOGICAL AND PATHOGENETIC PROPERTIES THAT UNDERLIE THE DIAGNOSIS OF INFECTIONS CAUSED BY PATHOGENIC MICROORGANISMS FOR HUMANS, IN PARTICULAR THOSE RESPONSIBLE FOR INFECTIONS OF THE UROGENITAL SYSTEM AND PRE- AND PERINATAL INFECTIONS; - THE DETERMINANTS OF HEALTH, RISK FACTORS AND PREVENTION STRATEGIES APPLIED TO THE PROMOTION AND SUPPORT OF THE HEALTH OF WOMEN, PREGNANT WOMEN, MOTHERS GIVING BIRTH, PUERPERAL WOMEN AND THE UNBORN CHILD. APPLYING KNOWLEDGE AND UNDERSTANDING AT THE END OF THE COURSE, STUDENTS WILL BE ABLE TO TRACE THE MOLECULAR AND CELLULAR CAUSES OF PATHOLOGIES AND INTEGRATE BIOLOGICAL AND LABORATORY KNOWLEDGE WITH CLINICAL KNOWLEDGE, EVALUATE THEIR COMPLEXITY AND FORMULATE JUDGMENTS BASED ON AVAILABLE EVIDENCE.

THE LESSONS WILL PROVIDE STUDENTS WITH THE ELEMENTS TO STUDY THE MECHANISMS UNDERLYING THE DISEASE PHENOMENON. IN PARTICULAR, THE AETIOLOGY, PATHOGENESIS AND BIOLOGICAL AND MOLECULAR BASES WITH WHICH DISEASES, INFECTIOUS AND OTHERWISE, PRODUCE SPECIFIC SIGNS OR SYMPTOMS WILL BE EXPLORED.

KNOWLEDGE AND UNDERSTANDING
AT THE END OF THE COURSE, STUDENTS WILL KNOW AND UNDERSTAND:
- THE BIOLOGICAL PHENOMENA OF THE MAIN MECHANISMS OF FUNCTIONING OF ORGANS AND SYSTEMS, SPECIFICALLY THE PHYSIOLOGY OF HUMAN REPRODUCTION AND EMBRYONIC DEVELOPMENT;
- THE PHYSIOPATHOLOGY OF THE REPRODUCTIVE SYSTEM AND ITS ENDOCRINE AND METABOLIC REGULATION, IN THE VARIOUS STAGES OF A WOMAN'S LIFE, AIMED AT BUILDING THE SPECIFIC SKILLS OF THE PROFESSIONAL PROFILE OF THE MIDWIFE;
- THE FUNDAMENTALS OF MICROBIOLOGY IN ORDER TO RECOGNIZE THE BIOLOGICAL AND PATHOGENETIC PROPERTIES THAT UNDERLIE THE DIAGNOSIS OF INFECTIONS CAUSED BY PATHOGENIC MICROORGANISMS FOR HUMANS, IN PARTICULAR THOSE RESPONSIBLE FOR INFECTIONS OF THE UROGENITAL SYSTEM AND PRE- AND PERINATAL INFECTIONS;
- THE DETERMINANTS OF HEALTH, RISK FACTORS AND PREVENTION STRATEGIES APPLIED TO THE PROMOTION AND SUPPORT OF THE HEALTH OF WOMEN, PREGNANT WOMEN, MOTHERS GIVING BIRTH, PUERPERAL WOMEN AND THE UNBORN CHILD.

APPLYING KNOWLEDGE AND UNDERSTANDING
AT THE END OF THE COURSE, STUDENTS WILL BE ABLE TO TRACE THE MOLECULAR AND CELLULAR CAUSES OF PATHOLOGIES AND INTEGRATE BIOLOGICAL AND LABORATORY KNOWLEDGE WITH CLINICAL KNOWLEDGE, EVALUATE THEIR COMPLEXITY AND FORMULATE JUDGMENTS BASED ON AVAILABLE EVIDENCE.

	Prerequisites
	The teaching presupposes basic biological knowledge concerning metabolism and cellular substructure, basic biochemical knowledge concerning the structure and function of the main classes of biological macromolecules. Propaedeutic to this teaching activity is the teaching of Notions of physics, biochemistry and applied biology.

	Contents
	THE COURSE IS DIVIDED INTO 4 MODULES: GENERAL PATHOLOGY (2 CREDITS – 24 HOURS), CLINICAL PATHOLOGY (1 CREDIT – 12 HOURS), MICROBIOLOGY AND CLINICAL MICROBIOLOGY (1 CREDIT – 12 HOURS), LABORATORY MEDICINE (2 CREDITS – 24 HOURS). GENERAL PATHOLOGY MODULE (MED 04, 2 CFU – 24 HOURS) DEFINITION OF DISEASE; CONCEPTS OF HOMEOSTASIS, ETIOLOGY AND PATHOGENESIS (2 HOURS). CAUSES OF DISEASE: PHYSICAL AND CHEMICAL AGENTS (3 HOURS). CELLULAR DAMAGE, MODES OF ADAPTATION: HYPOTROPHY, HYPERTROPHY, ATROPHY, HYPERPLASIA, METAPLASIA, HYPOPLASIA, APLASIA, DYSPLASIA (4 HOURS). CELL DEATH: APOPTOSIS, NECROSIS AND AUTOPHAGY (2 HOURS). ACUTE AND CHRONIC INFLAMMATION (4 HOURS). TISSUE REPAIR AND WOUND HEALING (2 HOURS). ONCOLOGY: NEOPLASTIC TRANSFORMATION; BENIGN TUMORS AND MALIGNANT TUMORS; TUMOR CLASSIFICATION (GRADING AND STAGING); DEFINITION AND MOLECULAR MECHANISMS OF ONCOGENES AND TUMOR SUPPRESSORS (4 HOURS). IMMUNITY AND IMMUNOPATHOLOGY: NATURAL IMMUNITY, ACQUIRED IMMUNITY, AUTOIMMUNITY (3 HOURS). CLINICAL PATHOLOGY MODULE (MED 05, 1 CFU – 12 HOURS) DIAGNOSIS OF THE COAGULATION AND FIBRINOLYTIC SYSTEM: LABORATORY TESTS FOR THE STUDY OF COAGULATION AND FIBRINOLYSIS. CLINICAL CASES OF VENOUS THROMBOEMBOLISM IN PREGNANCY AND PUERPERIUM. THROMBOPROPHYLAXIS (3 HOURS). COMPLETE BLOOD COUNT. ANEMIA. SIDERODEPRIVATION ANEMIA. CLINICAL CASES (2 HOURS). PROTEINS OF THE ACUTE PHASE OF INFLAMMATION. ELECTROPHORESIS. ACUTE AND CHRONIC INFLAMMATION. CHEMICAL MEDIATORS AND CELLS INVOLVED. EXUDATE. SYSTEMIC MANIFESTATIONS OF INFLAMMATION. ESR, CRP AND PROCALCITONIN (3 HOURS). DIAGNOSIS OF DIABETES: STUDY AND MONITORING. GLUCOSE LOAD CURVE IN PREGNANCY. INSULINS (2 HOURS). PREGNANCY COMPLICATIONS: HYPERTENSIVE DISORDERS (2 HOURS). MICROBIOLOGY AND CLINICAL MICROBIOLOGY MODULE (MED 07, 1 CFU – 12 HOURS) GENERAL BACTERIOLOGY. THE BACTERIAL CELL. BACTERIAL REPRODUCTION AND SPORE PRODUCTION. ENERGY METABOLISM (3 HOURS). BACTERIAL CULTIVATION, BACTERIAL GENETICS. ANTIBACTERIAL DRUGS. SPECIAL BACTERIOLOGY. THE VAGINAL MICROBIOME (2 HOURS) VIRUSES. CULTIVATION AND PURIFICATION OF VIRUSES. PRINCIPLES OF VIRAL TAXONOMY. ANTIVIRAL DRUGS. SPECIAL VIROLOGY (3 HOURS). FUNGAL CELL STRUCTURE. CLASSIFICATION NOTES. ANTIFUNGAL DRUGS. SPECIAL MYCOLOGY (2 HOURS). GENERAL CHARACTERISTICS OF PROTOZOA PATHOGENIC TO HUMANS. ANTIPROTOZOAN VACCINES. DRUGS WITH ANTIPROTOZOAN ACTION. SPECIAL PROTOZOOLOGY (2 HOURS). LABORATORY MEDICINE MODULE (MED 46, 2 CFU – 24 HOURS) BIOMARKERS (3 HOURS) CONVENTIONAL AND NON-CONVENTIONAL BIOLOGICAL MATRICES (3 HOURS) LABORATORY DATA VARIABILITY (3 HOURS) ANALYTICAL TECHNIQUES: SPECTROSCOPIC TECHNIQUES, ELECTROPHORETIC TECHNIQUES, CHROMATOGRAPHIC TECHNIQUES, CENTRIFUGATION TECHNIQUES, IMMUNOCHEMICAL AND IMMUNOENZYMATIC TECHNIQUES (6 HOURS) CLOTH COUNT (3 HOURS) COAGULATION (2 HOURS) LIVER FUNCTION (2 HOURS) RENAL FUNCTION (2 HOURS)

Contents

THE COURSE IS DIVIDED INTO 4 MODULES: GENERAL PATHOLOGY (2 CREDITS – 24 HOURS), CLINICAL PATHOLOGY (1 CREDIT – 12 HOURS), MICROBIOLOGY AND CLINICAL MICROBIOLOGY (1 CREDIT – 12 HOURS), LABORATORY MEDICINE (2 CREDITS – 24 HOURS).

GENERAL PATHOLOGY MODULE (MED 04, 2 CFU – 24 HOURS)
DEFINITION OF DISEASE; CONCEPTS OF HOMEOSTASIS, ETIOLOGY AND PATHOGENESIS (2 HOURS).
CAUSES OF DISEASE: PHYSICAL AND CHEMICAL AGENTS (3 HOURS).
CELLULAR DAMAGE, MODES OF ADAPTATION: HYPOTROPHY, HYPERTROPHY, ATROPHY, HYPERPLASIA, METAPLASIA, HYPOPLASIA, APLASIA, DYSPLASIA (4 HOURS).
CELL DEATH: APOPTOSIS, NECROSIS AND AUTOPHAGY (2 HOURS).
ACUTE AND CHRONIC INFLAMMATION (4 HOURS).
TISSUE REPAIR AND WOUND HEALING (2 HOURS).
ONCOLOGY: NEOPLASTIC TRANSFORMATION; BENIGN TUMORS AND MALIGNANT TUMORS; TUMOR CLASSIFICATION (GRADING AND STAGING); DEFINITION AND MOLECULAR MECHANISMS OF ONCOGENES AND TUMOR SUPPRESSORS (4 HOURS).
IMMUNITY AND IMMUNOPATHOLOGY: NATURAL IMMUNITY, ACQUIRED IMMUNITY, AUTOIMMUNITY (3 HOURS).

CLINICAL PATHOLOGY MODULE (MED 05, 1 CFU – 12 HOURS)
DIAGNOSIS OF THE COAGULATION AND FIBRINOLYTIC SYSTEM: LABORATORY TESTS FOR THE STUDY OF COAGULATION AND FIBRINOLYSIS. CLINICAL CASES OF VENOUS THROMBOEMBOLISM IN PREGNANCY AND PUERPERIUM. THROMBOPROPHYLAXIS (3 HOURS).
COMPLETE BLOOD COUNT. ANEMIA. SIDERODEPRIVATION ANEMIA. CLINICAL CASES (2 HOURS).
PROTEINS OF THE ACUTE PHASE OF INFLAMMATION. ELECTROPHORESIS. ACUTE AND CHRONIC INFLAMMATION. CHEMICAL MEDIATORS AND CELLS INVOLVED. EXUDATE. SYSTEMIC MANIFESTATIONS OF INFLAMMATION. ESR, CRP AND PROCALCITONIN (3 HOURS).
DIAGNOSIS OF DIABETES: STUDY AND MONITORING. GLUCOSE LOAD CURVE IN PREGNANCY. INSULINS (2 HOURS).
PREGNANCY COMPLICATIONS: HYPERTENSIVE DISORDERS (2 HOURS).

MICROBIOLOGY AND CLINICAL MICROBIOLOGY MODULE (MED 07, 1 CFU – 12 HOURS)
GENERAL BACTERIOLOGY. THE BACTERIAL CELL. BACTERIAL REPRODUCTION AND SPORE PRODUCTION. ENERGY METABOLISM (3 HOURS).
BACTERIAL CULTIVATION, BACTERIAL GENETICS. ANTIBACTERIAL DRUGS. SPECIAL BACTERIOLOGY. THE VAGINAL MICROBIOME (2 HOURS)
VIRUSES. CULTIVATION AND PURIFICATION OF VIRUSES. PRINCIPLES OF VIRAL TAXONOMY. ANTIVIRAL DRUGS. SPECIAL VIROLOGY (3 HOURS).
FUNGAL CELL STRUCTURE. CLASSIFICATION NOTES. ANTIFUNGAL DRUGS. SPECIAL MYCOLOGY (2 HOURS).
GENERAL CHARACTERISTICS OF PROTOZOA PATHOGENIC TO HUMANS. ANTIPROTOZOAN VACCINES. DRUGS WITH ANTIPROTOZOAN ACTION. SPECIAL PROTOZOOLOGY (2 HOURS).

LABORATORY MEDICINE MODULE (MED 46, 2 CFU – 24 HOURS)
BIOMARKERS (3 HOURS)
CONVENTIONAL AND NON-CONVENTIONAL BIOLOGICAL MATRICES (3 HOURS)
LABORATORY DATA VARIABILITY (3 HOURS)
ANALYTICAL TECHNIQUES: SPECTROSCOPIC TECHNIQUES, ELECTROPHORETIC TECHNIQUES, CHROMATOGRAPHIC TECHNIQUES, CENTRIFUGATION TECHNIQUES, IMMUNOCHEMICAL AND IMMUNOENZYMATIC TECHNIQUES (6 HOURS)
CLOTH COUNT (3 HOURS)
COAGULATION (2 HOURS)
LIVER FUNCTION (2 HOURS)
RENAL FUNCTION (2 HOURS)

	Teaching Methods
	THE COURSE INCLUDES LECTURES AND SEMINAR ACTIVITIES FOR A TOTAL DURATION OF 72 HOURS. ATTENDANCE AT CLASSROOM LESSONS IS MANDATORY AND ACCESS TO THE EXAM REQUIRES ATTENDANCE OF AT LEAST 75% OF THE HOURS SCHEDULED FOR THE COURSE. ATTENDANCE WILL BE VERIFIED USING THE EASYACADEMY SOFTWARE.

	Verification of learning
	The achievement of the objectives of the course is verified by passing an oral exam lasting approximately 15 minutes for each module with an evaluation in thirtieths. The test allows to ascertain the ability of knowledge and understanding, the ability to apply the skills acquired and the ability to present. Furthermore, it will allow to verify the theoretical knowledge, with reference to the basic mechanisms of human pathology, the meaning of laboratory tests, the cellular and molecular bases of microbial activity, microorganism/host interactions and related diagnostic-clinical aspects. The final grade of the exam of the integrated course is the weighted average of the grades of the individual modules. Honors requires achieving the maximum grades in all the modules of the course.

Verification of learning

The achievement of the objectives of the course is verified by passing an oral exam lasting approximately 15 minutes for each module with an evaluation in thirtieths. The test allows to ascertain the ability of knowledge and understanding, the ability to apply the skills acquired and the ability to present. Furthermore, it will allow to verify the theoretical knowledge, with reference to the basic mechanisms of human pathology, the meaning of laboratory tests, the cellular and molecular bases of microbial activity, microorganism/host interactions and related diagnostic-clinical aspects. The final grade of the exam of the integrated course is the weighted average of the grades of the individual modules. Honors requires achieving the maximum grades in all the modules of the course.

	Texts
	- AA VV PATOLOGIA GENERALE E FISIOPATOLOGIA, IDELSON – GNOCCHI - ROBBINS, KUMAE &KLATT- LE BASI PATOLOGICHE DELLE MALATTIE, EDRA MASSON. - MICROBIOLOGIA MEDICA, BATTERIOLOGIA E VIROLOGIA DI MARIA PIA CONTE, PAOLA MASTROMARINO. SOCIETÀ EDITRICE ESCULAPIO. ELEMENTI DI BIOCHIMICA CLINICA E MEDICINA DI LABORATORIO. MARCELLO CIACCIO. EDISES EDIZIONI. TEACHING MATERIALS: SLIDES OF THE LECTURES

	More Information
	THE OFFICIAL TEACHING LANGUAGE IS ITALIAN. LESSONS WILL BE HELD AT THE UNIVERSITY HOSPITAL "SAN GIOVANNI DI DIO E RUGGI D'ARAGONA" IN SALERNO.

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JESSICA DAL COL | General Pathology and Microbiology