Daniela GUARNIERI | CELL AND TISSUE BIOLOGY

cod. 0512800038

CELL AND TISSUE BIOLOGY

	0512800038
	DEPARTMENT OF CHEMISTRY AND BIOLOGY "ADOLFO ZAMBELLI"
	EQF6
	BIOLOGICAL SCIENCES
	2024/2025

PERCORSO SHARED STUDY PLAN

	OBBLIGATORIO
	YEAR OF COURSE 1
	YEAR OF DIDACTIC SYSTEM 2016
	FULL ACADEMIC YEAR

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	BIOLOGIA DELLA CELLULA
	BIO/13	5	40	LESSONS	SUPPLEMENTARY COMPULSORY SUBJECTS
	BIO/13	1	12	EXERCISES	SUPPLEMENTARY COMPULSORY SUBJECTS
2	BIOLOGIA DEI TESSUTI
	BIO/06	3	24	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
	BIO/06	1	12	LAB	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	DANIELA GUARNIERI1 T Curriculum
	-2

EXAMS

	Exam	Date	Session
	BIOLOGIA DELLA CELLULA E DEI TESSUTI	22/01/2025 - 09:00	SESSIONE DI SECUPERO
	BIOLOGIA DELLA CELLULA E DEI TESSUTI	07/02/2025 - 09:00	SESSIONE DI SECUPERO

	Objectives
	GENERAL OBJECTIVE - THE COURSE INTENDS TO: PROVIDE STUDENTS WITH BASIC KNOWLEDGE ON THE STRUCTURAL ORGANIZATION OF EUKARYOTIC CELLS; PROVIDE STUDENTS WITH A GENERAL FRAMEWORK OF THE FUNCTIONAL MEANING AND RELATIONSHIPS BETWEEN THE DIFFERENT CELLULAR ORGANELLES; OUTLINE THE MECHANISMS OF INTEGRATION OF THE ACTIVITIES OF SPECIALIZED CELLS TO FORM TISSUES; PROVIDE KNOWLEDGE ON THE STRUCTURAL AND FUNCTIONAL ORGANIZATION OF TISSUES. KNOWLEDGE AND UNDERSTANDING - THE STUDENT WILL KNOW THE BASIC DISCIPLINARY FOUNDATIONS OF CELL AND TISSUE BIOLOGY; WILL DEVELOP OBSERVATION SKILLS OF CELLULAR, TISSUE AND ORGAN STRUCTURES, AND OF THE MAIN BIOLOGICAL PROCESSES; WILL UNDERSTAND THE RELATIONSHIPS BETWEEN STRUCTURE AND FUNCTION OF A BIOLOGICAL MACROMOLECULE, AN INTRACELLULAR ORGANELLE AND A TISSUE. ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING - THE STUDENT WILL ACQUIRE THE BASIC TOOLS TO UNDERSTAND AND DISCUSS THE MAIN CONCEPTS RELATED TO CELL AND TISSUE BIOLOGY. THE STUDENT WILL BE ABLE TO EXAMINE REPRESENTATIVE IMAGES OF CELLS AND TISSUES; TO DISCRIMINATE BETWEEN THE DIFFERENT CYTO-HISTOLOGICAL PREPARATIONS AND THE DIFFERENT PREPARATION TECHNIQUES OF THE SAME. AUTONOMY OF JUDGEMENT - THE STUDENT WILL ACQUIRE THE ABILITY TO ANALYZE AND DISCRIMINATE BETWEEN DIFFERENT OPTIONS; ABILITY TO EVALUATE AND SELECT THE OPTIMAL SOLUTION TO RESPOND TO A SPECIFIC PROBLEM. COMMUNICATION SKILLS - THE STUDENT WILL BE ABLE TO COMMUNICATE AND DESCRIBE THE BASIC NOTIONS OF CELL BIOLOGY, ANIMAL CYTO-HISTOLOGICAL STRUCTURES AND BIOLOGICAL PROCESSES USING A SPECIFIC VOCABULARY. LEARNING ABILITY - IMPROVEMENT OF THE ABILITY TO USE TRADITIONAL BIBLIOGRAPHIC TOOLS AND IT RESOURCES AND TO ACQUIRE AND CONNECT INFORMATION INDEPENDENTLY.

GENERAL OBJECTIVE - THE COURSE INTENDS TO: PROVIDE STUDENTS WITH BASIC KNOWLEDGE ON THE STRUCTURAL ORGANIZATION OF EUKARYOTIC CELLS; PROVIDE STUDENTS WITH A GENERAL FRAMEWORK OF THE FUNCTIONAL MEANING AND RELATIONSHIPS BETWEEN THE DIFFERENT CELLULAR ORGANELLES; OUTLINE THE MECHANISMS OF INTEGRATION OF THE ACTIVITIES OF SPECIALIZED CELLS TO FORM TISSUES; PROVIDE KNOWLEDGE ON THE STRUCTURAL AND FUNCTIONAL ORGANIZATION OF TISSUES.
KNOWLEDGE AND UNDERSTANDING - THE STUDENT WILL KNOW THE BASIC DISCIPLINARY FOUNDATIONS OF CELL AND TISSUE BIOLOGY; WILL DEVELOP OBSERVATION SKILLS OF CELLULAR, TISSUE AND ORGAN STRUCTURES, AND OF THE MAIN BIOLOGICAL PROCESSES; WILL UNDERSTAND THE RELATIONSHIPS BETWEEN STRUCTURE AND FUNCTION OF A BIOLOGICAL MACROMOLECULE, AN INTRACELLULAR ORGANELLE AND A TISSUE.
ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING - THE STUDENT WILL ACQUIRE THE BASIC TOOLS TO UNDERSTAND AND DISCUSS THE MAIN CONCEPTS RELATED TO CELL AND TISSUE BIOLOGY. THE STUDENT WILL BE ABLE TO EXAMINE REPRESENTATIVE IMAGES OF CELLS AND TISSUES; TO DISCRIMINATE BETWEEN THE DIFFERENT CYTO-HISTOLOGICAL PREPARATIONS AND THE DIFFERENT PREPARATION TECHNIQUES OF THE SAME.
AUTONOMY OF JUDGEMENT - THE STUDENT WILL ACQUIRE THE ABILITY TO ANALYZE AND DISCRIMINATE BETWEEN DIFFERENT OPTIONS; ABILITY TO EVALUATE AND SELECT THE OPTIMAL SOLUTION TO RESPOND TO A SPECIFIC PROBLEM.
COMMUNICATION SKILLS - THE STUDENT WILL BE ABLE TO COMMUNICATE AND DESCRIBE THE BASIC NOTIONS OF CELL BIOLOGY, ANIMAL CYTO-HISTOLOGICAL STRUCTURES AND BIOLOGICAL PROCESSES USING A SPECIFIC VOCABULARY.
LEARNING ABILITY - IMPROVEMENT OF THE ABILITY TO USE TRADITIONAL BIBLIOGRAPHIC TOOLS AND IT RESOURCES AND TO ACQUIRE AND CONNECT INFORMATION INDEPENDENTLY.

	Prerequisites
	NO PREREQUISITES

	Contents
	THE COURSE IS WELL-STRUCTURED INTO TWO MODULES NAMED CELL BIOLOGY AND TISSUE BIOLOGY. CONTENTS OF CELL BIOLOGY MODULE ORGANIZATION LEVELS IN BIOLOGY: VIRUS, VIROIDS, PRIONS, PROKARYOTES, EUKARYOTES. (2 H LECTURE) NOTES OF GENERAL BIOCHEMISTRY: WATER, LIPIDS, GLUCIDS, PROTIDES, THEIR STRUCTURE. NUCLEIC ACIDS (DNA AND RNA), NOTES ON DUPLICATION AND TRANSCRIPTION. (4 H LECTURE) THE PLASMATIC MEMBRANE: STRUCTURE AND FUNCTIONS (STRUCTURAL MODELS, PERMEABILITY, ACTIVE AND PASSIVE TRANSPORT, TRANSPORT MECHANISMS), THE GLYCOCALIX AND ITS FUNCTION, THE CELL JUNCTIONS. (4 H LECTURE) TRAINING (3H) THE CELLULAR SURFACE: DIFFERENTIATIONS OF THE CELLULAR SURFACE (MICROVILLI, EYELASHES AND FLAGELLAS, JOINT SYSTEMS BETWEEN CELLS, CELL INTERACTIONS, INHIBITION BY CONTACT, COMMUNICATION BETWEEN CELLS). (2 H LECTURE) CYTOPLASMA: THE CYTOSKELETON (MICROTUBULES, MICROFILAMENTS AND INTERMEDIATE FILAMENTS), RELATIONSHIP BETWEEN THE CYTOSKELETON AND PLASMATIC MEMBRANE, CELL MIGRATION. (4 H LECTURE) THE SMOOTH AND ROUGH ENDOPLASMATIC RETICULA AND THEIR FUNCTIONS (3 H LECTURE) TRAINING (3H) THE GOLGI APPARATUS, CELLULAR SECRETION, LYSOSOMES (CELLULAR DIGESTION). VESICULAR TRANSPORT. (4 H LECTURE) EXOCYTOSIS AND ENDOCYTOSIS; PEROXYSOMES, MITOCHONDRIA, CELLULAR METABOLISM. (4 H LECTURE) TRAINING (3H) THE NUCLEUS: THE NUCLEAR ENVELOPE; DNA; CHROMATIN, COMPOSITION AND STRUCTURE, HETEROCHROMATIN AND EUCHROMATIN; CHROMOSOMES; DNA DUPLICATION; DNA TRANSCRIPTION HETEROGENEOUS RNA. (4 H LECTURE) THE NUCLEOL AND THE BIOGENESIS OF THE RIBOSOMES; STRUCTURE AND ULTRASTRUCTURE OF RIBOSOMES. NOTES ON THE PROTEIN SYNTHESIS. (2 H LECTURE) CELL CYCLE. MYTHOSIS AND ITS REGULATION. (4 H LECTURE) MEYOSIS AND ITS BIOLOGICAL MEANING (3 H LECTURE) TRAINING (3H) CONTENTS OF TISSUE BIOLOGY MODULE THE MAIN TECHNIQUES AND EQUIPMENT FOR THE STUDY OF CELLS AND TISSUES. (2 H LECTURE + 12 H LABORATORY) EPITHELIAL TISSUE; COVERING EPITHELIA; EXOCRINE GLANDS, ENDOCRINE GLANDS AND THEIR FUNCTION. (6 H LECTURE) CONNECTIVE TISSUE: PROPER CONNECTIVE TISSUE: THE FUNDAMENTAL SUBSTANCE (AMORPHOUS PART AND FIBERS). CONNECTIVE CELLS AND THEIR FUNCTION. NOTES ON DEFENSE MECHANISMS; SPECIALIZED CONNECTIVE TISSUES: CARTILAGE; BONE TISSUE AND OXIFICATION PROCESSES; BLOOD: PLASMA, SERUM, HEMATOCRIT, ERYTHROCYTES, LEUKOCYTES, PLATES. SET-UP TECHNIQUES AND READING OF BLOOD STRIP. HEMATOPOIESIS. THE LYMPHATIC TISSUE AND THE IMMUNE SYSTEM. (6 H LECTURE) MUSCLE TISSUE: SKELETAL, CARDIAC AND SMOOTH MUSCLE; CONTRACTION MECHANISMS. (5 H LECTURE) NERVOUS TISSUE: NEURON AND ITS STRUCTURE; NERVOUS FIBER AND MYELIN SHEATHS, AXONIC FLOW; SYNAPSES AND NEUROMUSCULAR JUNCTIONS. THE TRANSMISSION OF THE NERVE IMPULSE. GLIA AND ITS FUNCTION. (5 H LECTURE)

Contents

THE COURSE IS WELL-STRUCTURED INTO TWO MODULES NAMED CELL BIOLOGY AND TISSUE BIOLOGY.

CONTENTS OF CELL BIOLOGY MODULE
ORGANIZATION LEVELS IN BIOLOGY: VIRUS, VIROIDS, PRIONS, PROKARYOTES, EUKARYOTES. (2 H LECTURE)
NOTES OF GENERAL BIOCHEMISTRY: WATER, LIPIDS, GLUCIDS, PROTIDES, THEIR STRUCTURE. NUCLEIC ACIDS (DNA AND RNA), NOTES ON DUPLICATION AND TRANSCRIPTION. (4 H LECTURE)
THE PLASMATIC MEMBRANE: STRUCTURE AND FUNCTIONS (STRUCTURAL MODELS, PERMEABILITY, ACTIVE AND PASSIVE TRANSPORT, TRANSPORT MECHANISMS), THE GLYCOCALIX AND ITS FUNCTION, THE CELL JUNCTIONS. (4 H LECTURE)
TRAINING (3H)
THE CELLULAR SURFACE: DIFFERENTIATIONS OF THE CELLULAR SURFACE (MICROVILLI, EYELASHES AND FLAGELLAS, JOINT SYSTEMS BETWEEN CELLS, CELL INTERACTIONS, INHIBITION BY CONTACT, COMMUNICATION BETWEEN CELLS). (2 H LECTURE)
CYTOPLASMA: THE CYTOSKELETON (MICROTUBULES, MICROFILAMENTS AND INTERMEDIATE FILAMENTS), RELATIONSHIP BETWEEN THE CYTOSKELETON AND PLASMATIC MEMBRANE, CELL MIGRATION. (4 H LECTURE)
THE SMOOTH AND ROUGH ENDOPLASMATIC RETICULA AND THEIR FUNCTIONS (3 H LECTURE)
TRAINING (3H)
THE GOLGI APPARATUS, CELLULAR SECRETION, LYSOSOMES (CELLULAR DIGESTION). VESICULAR TRANSPORT. (4 H LECTURE)
EXOCYTOSIS AND ENDOCYTOSIS; PEROXYSOMES, MITOCHONDRIA, CELLULAR METABOLISM. (4 H LECTURE)
TRAINING (3H)
THE NUCLEUS: THE NUCLEAR ENVELOPE; DNA; CHROMATIN, COMPOSITION AND STRUCTURE, HETEROCHROMATIN AND EUCHROMATIN; CHROMOSOMES; DNA DUPLICATION; DNA TRANSCRIPTION HETEROGENEOUS RNA. (4 H LECTURE)
THE NUCLEOL AND THE BIOGENESIS OF THE RIBOSOMES; STRUCTURE AND ULTRASTRUCTURE OF RIBOSOMES. NOTES ON THE PROTEIN SYNTHESIS. (2 H LECTURE)
CELL CYCLE. MYTHOSIS AND ITS REGULATION. (4 H LECTURE)
MEYOSIS AND ITS BIOLOGICAL MEANING (3 H LECTURE)
TRAINING (3H)

CONTENTS OF TISSUE BIOLOGY MODULE
THE MAIN TECHNIQUES AND EQUIPMENT FOR THE STUDY OF CELLS AND TISSUES. (2 H LECTURE + 12 H LABORATORY)
EPITHELIAL TISSUE; COVERING EPITHELIA; EXOCRINE GLANDS, ENDOCRINE GLANDS AND THEIR FUNCTION. (6 H LECTURE)
CONNECTIVE TISSUE: PROPER CONNECTIVE TISSUE: THE FUNDAMENTAL SUBSTANCE (AMORPHOUS PART AND FIBERS). CONNECTIVE CELLS AND THEIR FUNCTION. NOTES ON DEFENSE MECHANISMS; SPECIALIZED CONNECTIVE TISSUES: CARTILAGE; BONE TISSUE AND OXIFICATION PROCESSES; BLOOD: PLASMA, SERUM, HEMATOCRIT, ERYTHROCYTES, LEUKOCYTES, PLATES. SET-UP TECHNIQUES AND READING OF BLOOD STRIP. HEMATOPOIESIS. THE LYMPHATIC TISSUE AND THE IMMUNE SYSTEM. (6 H LECTURE)
MUSCLE TISSUE: SKELETAL, CARDIAC AND SMOOTH MUSCLE; CONTRACTION MECHANISMS. (5 H LECTURE)
NERVOUS TISSUE: NEURON AND ITS STRUCTURE; NERVOUS FIBER AND MYELIN SHEATHS, AXONIC FLOW; SYNAPSES AND NEUROMUSCULAR JUNCTIONS. THE TRANSMISSION OF THE NERVE IMPULSE. GLIA AND ITS FUNCTION. (5 H LECTURE)

	Teaching Methods
	THE COURSE PROVIDES 88 HOURS (10 CFU) OF DIDACTICS DIVIDED INTO THEORY LESSONS (8 CFU) AND CLASSROOM EXERCISES (1 CFU), AND LABORATORY (1 CFU). THE CLASSROOM EXERCISES WILL CONSIST OF QUESTIONNAIRES AND TESTS ADMINISTERED TO STUDENTS DURING THE COURSE IN ORDER TO MONITORING LEARNING AND, POSSIBLY, PREPARING ACTIONS TO RECOVER AND/OR ENHANCE THE KNOWLEDGE AND SKILLS ACQUIRED. THE LABORATORY WILL PROVIDE THE ACQUISITION OF THE MAIN TECHNIQUES FOR THE PREPARATION OF HISTOLOGICAL SAMPLES AND THE RECOGNITION OF SAMPLES BY THE MICROSCOPE.

Teaching Methods

THE COURSE PROVIDES 88 HOURS (10 CFU) OF DIDACTICS DIVIDED INTO THEORY LESSONS (8 CFU) AND CLASSROOM EXERCISES (1 CFU), AND LABORATORY (1 CFU). THE CLASSROOM EXERCISES WILL CONSIST OF QUESTIONNAIRES AND TESTS ADMINISTERED TO STUDENTS DURING THE COURSE IN ORDER TO MONITORING LEARNING AND, POSSIBLY, PREPARING ACTIONS TO RECOVER AND/OR ENHANCE THE KNOWLEDGE AND SKILLS ACQUIRED. THE LABORATORY WILL PROVIDE THE ACQUISITION OF THE MAIN TECHNIQUES FOR THE PREPARATION OF HISTOLOGICAL SAMPLES AND THE RECOGNITION OF SAMPLES BY THE MICROSCOPE.

	Verification of learning
	THE ACHIEVEMENT OF THE OBJECTIVES OF THE TEACHING WILL BE VERIFIED BY PASSING AN EXAM TEST. THE EXAMINATION CONSISTS OF TWO ORAL INTERVIEWS, ONE FOR EACH MODULE, TO CHECK THE LEARNING OF THE TOPICS PROPOSED BY THE TEACHERS DURING THE COURSE. THE FINAL VOTE WILL BE EXPRESSED IN THIRTYTH AND WILL CORRESPOND TO THE ARITHMETIC MEAN OF THE MARKS OF THE TWO MODULES. THE RECORD OF THE FINAL MARK IS SUBJECT TO PASSING THE EXAMS RELATED TO THE TWO MODULES WITH A MARK NOT LESS THAN 18/30. FOR BOTH MODULES, THE MINIMUM MARK (18/30) IS REACHED WHEN THE EXAM DEMONSTRATES THE ACHIEVEMENT OF A SUFFICIENT LEVEL IN KNOWLEDGE, LANGUAGE ABILITY AND QUALITY OF PRESENTATION. THE MAXIMUM MARK (30/30) IS ACHIEVED WHEN THE STUDENT DEMONSTRATES, WITH THE EXAM, FULL AND COMPLETE KNOWLEDGE AND OWNERSHIP OF LANGUAGE ON THE TOPICS ADDRESSED, WITH MAXIMUM QUALITY OF PRESENTATION AND ABILITY TO APPLY KNOWLEDGE IN PRACTICAL ACTIVITIES. HONORS ARE AWARDED WHEN THE EXAM DEMONSTRATES, IN ADDITION TO THE HIGHEST POSSIBLE RESULT IN BOTH MODULES, A PARTICULAR QUALITY OF PRESENTATION WITH CRITICAL ANALYSIS SKILLS.

Verification of learning

THE ACHIEVEMENT OF THE OBJECTIVES OF THE TEACHING WILL BE VERIFIED BY PASSING AN EXAM TEST. THE EXAMINATION CONSISTS OF TWO ORAL INTERVIEWS, ONE FOR EACH MODULE, TO CHECK THE LEARNING OF THE TOPICS PROPOSED BY THE TEACHERS DURING THE COURSE.
THE FINAL VOTE WILL BE EXPRESSED IN THIRTYTH AND WILL CORRESPOND TO THE ARITHMETIC MEAN OF THE MARKS OF THE TWO MODULES. THE RECORD OF THE FINAL MARK IS SUBJECT TO PASSING THE EXAMS RELATED TO THE TWO MODULES WITH A MARK NOT LESS THAN 18/30. FOR BOTH MODULES, THE MINIMUM MARK (18/30) IS REACHED WHEN THE EXAM DEMONSTRATES THE ACHIEVEMENT OF A SUFFICIENT LEVEL IN KNOWLEDGE, LANGUAGE ABILITY AND QUALITY OF PRESENTATION. THE MAXIMUM MARK (30/30) IS ACHIEVED WHEN THE STUDENT DEMONSTRATES, WITH THE EXAM, FULL AND COMPLETE KNOWLEDGE AND OWNERSHIP OF LANGUAGE ON THE TOPICS ADDRESSED, WITH MAXIMUM QUALITY OF PRESENTATION AND ABILITY TO APPLY KNOWLEDGE IN PRACTICAL ACTIVITIES. HONORS ARE AWARDED WHEN THE EXAM DEMONSTRATES, IN ADDITION TO THE HIGHEST POSSIBLE RESULT IN BOTH MODULES, A PARTICULAR QUALITY OF PRESENTATION WITH CRITICAL ANALYSIS SKILLS.

	Texts
	MAIN BOOK: CYTOLOGY AND HISTOLOGY, ISABELLA DALLE DONNE, EDISES IN-DEPTH CONSULTATION BOOKS: MOLECULAR BIOLOGY OF THE CELL, ALBERTS ET AL., ZANICHELLI ELEMENTS OF HISTOLOGY, ROBERTA DI PIETRO, EDISES

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Daniela GUARNIERI | CELL AND TISSUE BIOLOGY