Federica PAPACCIO | HISTOLOGY AND HUMAN EMBRYOLOGY

cod. 1060100007

HISTOLOGY AND HUMAN EMBRYOLOGY

	1060100007
	DEPARTMENT OF MEDICINE, SURGERY AND DENTISTRY "SALERNITANA MEDICAL SCHOOL"
	EQF7
	MEDICINE AND SURGERY
	2024/2025

PERCORSO SHARED STUDY PATHWAY

	OBBLIGATORIO
	YEAR OF COURSE 1
	YEAR OF DIDACTIC SYSTEM 2016
	SPRING SEMESTER

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
	BIO/17	7	84	LESSONS	BASIC COMPULSORY SUBJECTS

EXAMS

	Exam	Date	Session
	ISTOLOGIA ED EMBRIOLOGIA UMANA	18/12/2024	SESSIONE ORDINARIA
	ISTOLOGIA ED EMBRIOLOGIA UMANA	18/12/2024	SESSIONE DI RECUPERO

	Objectives
	KNOWLEDGE OF MORPHOLOGICAL INVESTIGATION METHODS AND OF THE HISTOLOGY LABORATORY; KNOWLEDGE OF STRUCTURE AND ULTRASTRUCTURE OF THE CELL (IN CONNECTION WITH BIOLOGY) AND OF THE FUNDAMENTAL TISSUES, OF DIFFERENTIATION, GROWTH AND THE STAGES THAT LEAD TO THE DEVELOPMENT OF THE HUMAN ORGANISM, INCLUDING THE MAIN MORPHOGENETIC FACTORS AND REGULATORY GENES. THE STUDENT MUST ACQUIRE KNOWLEDGE OF INVESTIGATION METHODS IN CYTOLOGY, HISTOLOGY, HISTOCHEMISTRY, IMMUNOHISTOCHEMISTRY, AND EMBRYOLOGY; HE MUST ACQUIRE THE ABILITY TO RECOGNIZE THE CELL AND ITS OWN CONSTITUENTS AT THE MICROSCOPIC AND ULTRAMICROSCOPIC LEVEL, TOGETHER WITH FUNDAMENTAL KNOWLEDGE OF THE SUBMICROSCOPIC STRUCTURE DOWN TO THE MACROMOLECULAR LEVEL. THE STUDENT MUST ALSO ACQUIRE THE ABILITY TO RECOGNIZE UNDER THE OPTICAL MICROSCOPE AND DESCRIBE THE BASIC TISSUES AND THEIR VARIANTS; FINALLY, HE MUST DEMONSTRATE THAT HE KNOWS THE MECHANISMS OF CELL DIFFERENTIATION, CELL-CELL INTERACTIONS, HISTOGENESIS. IN EMBRYOLOGY HE WILL HAVE TO DEMONSTRATE TO HAVE ACQUIRED KNOWLEDGE OF ALL THE STAGES OF DEVELOPMENT FROM GAMETOGENESIS TO THE ORGANOGENESIS OF ALL THE SYSTEMS AND THE MAIN MORPHOGENETIC PROCESSES AND MECHANISMS.

KNOWLEDGE OF MORPHOLOGICAL INVESTIGATION METHODS AND OF THE HISTOLOGY LABORATORY; KNOWLEDGE OF
STRUCTURE AND ULTRASTRUCTURE OF THE CELL (IN CONNECTION WITH BIOLOGY) AND OF THE FUNDAMENTAL TISSUES, OF DIFFERENTIATION, GROWTH AND THE STAGES THAT LEAD TO THE DEVELOPMENT OF THE HUMAN ORGANISM, INCLUDING THE MAIN MORPHOGENETIC FACTORS AND REGULATORY GENES.
THE STUDENT MUST ACQUIRE KNOWLEDGE OF INVESTIGATION METHODS IN CYTOLOGY, HISTOLOGY, HISTOCHEMISTRY, IMMUNOHISTOCHEMISTRY, AND EMBRYOLOGY; HE MUST ACQUIRE THE ABILITY TO RECOGNIZE THE CELL AND ITS OWN CONSTITUENTS AT THE MICROSCOPIC AND ULTRAMICROSCOPIC LEVEL, TOGETHER WITH FUNDAMENTAL KNOWLEDGE OF THE SUBMICROSCOPIC STRUCTURE DOWN TO THE MACROMOLECULAR LEVEL.
THE STUDENT MUST ALSO ACQUIRE THE ABILITY TO RECOGNIZE UNDER THE OPTICAL MICROSCOPE AND DESCRIBE THE BASIC TISSUES AND THEIR VARIANTS; FINALLY, HE MUST DEMONSTRATE THAT HE KNOWS THE MECHANISMS OF
CELL DIFFERENTIATION, CELL-CELL INTERACTIONS, HISTOGENESIS. IN EMBRYOLOGY HE WILL HAVE TO
DEMONSTRATE TO HAVE ACQUIRED KNOWLEDGE OF ALL THE STAGES OF DEVELOPMENT FROM GAMETOGENESIS TO THE ORGANOGENESIS OF ALL THE SYSTEMS AND THE MAIN MORPHOGENETIC PROCESSES AND MECHANISMS.

	Prerequisites
	IT IS REQUIRED THE KNOWLEDGE OF THE STRUCTURE AND FUNCTIONAL ORGANIZATION OF THE CELL. THE STUDENT MUST HAVE PASSED THE EXAM OF APPLIED BIOLOGY.

	Contents
	THE COURSE CONSISTS OF A UNIQUE MODULE (7 CFU-84 HOURS). A) HISTOLOGY: METHODS AND MEANS OF INVESTIGATION FOR THE OBSERVATION OF CELLS, TISSUES AND ORGANS. CELL DIFFERENTIATION. HISTOGENESIS. CHEMICAL COMMUNICATION BETWEEN CELLS. COATING EPITHELIA. SENSORY AND PARTICULARLY DIFFERENTIATED EPITHELIA. EXOCRINE AND ENDOCRINE GLANDS, THEIR CLASSIFICATION AND MORPHOLOGICAL ORGANIZATION. SUPPORTING TISSUES: CONNECTIVE TISSUE PROPER AND VARIANTS. CELLULAR ELEMENTS, FIBERS AND CONNECTIVE MATRIX. CONNECTIVE TISSUES WITH SPECIAL PROPERTIES. THE WHITE, BROWN, BEIGE AND PINK ADIPOSE TISSUE. THEIR FUNCTION, REGULATION AND ENDOCRINE ACTION. CARTILAGE TISSUE. BONE TISSUE, ITS ORGANIZATION AND METABOLISM. TYPES OF OSSIFICATION. BONE REMODELING. BLOOD AND LYMPH. HEMATOPOIESIS IN THE EMBRYO AND IN ADULTS. THE BONE MARROW. LYMPHOID TISSUE AND ITS ROLE IN IMMUNOCOMPETENCE. THYMUS FUNCTION AND POSITIVE AND NEGATIVE CLONAL SELECTION. PRINCIPLES OF HISTOPHYSIOLOGY AND PHYSIOLOGY OF THE IMMUNE SYSTEM (INNATE AND ACQUIRED IMMUNITY, MOLECULAR MECHANISMS AND CLINICAL CORRELATIONS, IMMUNOTHERAPY RATIONALE). MUSCLE TISSUE: SMOOTH, SKELETAL STRIATUM AND CARDIAC STRIATUM. MOLECULAR BASIS OF MUSCLE CONTRACTION. NERVOUS TISSUE AND NEUROSIS. SYNAPSES: TRAINING AND ROLE. MOTIVE PLATE. PERIPHERAL NERVE STRUCTURE. OF ALL TISSUES IT IS NECESSARY TO KNOW HISTOPHYSIOLOGY AND CLINICAL CORRELATIONS. STEM CELLS: TYPES, NICHE, CLINICAL CORRELATIONS. B) EMBRIOLOGY: REPRODUCTION. MOLECULAR MECHANISMS OF DEVELOPMENT. THE MALE AND FEMALE GONADS. GAMETOGENESIS. FERTILIZATION. PREPARATION FOR NESTING. FIRST AND SECOND WEEK OF DEVELOPMENT: SEGMENTATION, FORMATION OF THE EMBRYONIC AREA. THIRD WEEK: GASTRULATION, PRIMARY EMT. NOTOCHORD. FOURTH WEEK: FOLDING OF THE EMBRYO AND DELIMITATION OF THE EMBRYONIC AREA. EVOLUTION OF THE ECTODERM: FORMATION OF THE NEURAL TUBE. PRIMARY, DEFINITIVE AND DERIVATIVE BRAIN VESICLES. PLACODES. EVOLUTION OF THE MESODERM: SOMITES, INTERMEDIATE MESODERM, LATERAL MESODERM AND THEIR DERIVATIVES. DEVELOPMENT OF THE UROGENITAL SYSTEM. EVOLUTION OF THE ENDODERM: FORMATION OF THE PRIMITIVE INTESTINE AND ITS DIFFERENTIATION. CLOACA AND ITS DERIVATIONS. RESPIRATORY SYSTEM DEVELOPMENT. PHARYNGEAL APPARATUS AND ITS DERIVATIVES. FACE DEVELOPMENT. FORMATION OF BONES AND MUSCLES. DEVELOPMENT OF THE CARDIOVASCULAR SYSTEM. DEVELOPMENT OF EMBRYONIC ANNEXES. DEVELOPMENTAL DEFECTS AND MALFORMATIONS OF ALL APPARATUSES AND SYSTEMS. AT EACH STAGE OF DEVELOPMENT, IT IS NECESSARY TO KNOW THE GENES, PROCESSES AND MOLECULES INVOLVED.

Contents

THE COURSE CONSISTS OF A UNIQUE MODULE (7 CFU-84 HOURS).
A) HISTOLOGY: METHODS AND MEANS OF INVESTIGATION FOR THE OBSERVATION OF CELLS, TISSUES AND
ORGANS. CELL DIFFERENTIATION. HISTOGENESIS. CHEMICAL COMMUNICATION BETWEEN CELLS.
COATING EPITHELIA. SENSORY AND PARTICULARLY DIFFERENTIATED EPITHELIA. EXOCRINE AND ENDOCRINE GLANDS, THEIR CLASSIFICATION AND MORPHOLOGICAL ORGANIZATION. SUPPORTING TISSUES: CONNECTIVE TISSUE PROPER AND VARIANTS. CELLULAR ELEMENTS, FIBERS AND CONNECTIVE MATRIX. CONNECTIVE TISSUES WITH SPECIAL PROPERTIES. THE WHITE, BROWN, BEIGE AND PINK ADIPOSE TISSUE. THEIR FUNCTION, REGULATION AND ENDOCRINE ACTION.
CARTILAGE TISSUE. BONE TISSUE, ITS ORGANIZATION AND METABOLISM. TYPES OF OSSIFICATION. BONE REMODELING.
BLOOD AND LYMPH. HEMATOPOIESIS IN THE EMBRYO AND IN ADULTS. THE BONE MARROW. LYMPHOID TISSUE AND ITS ROLE IN IMMUNOCOMPETENCE. THYMUS FUNCTION AND POSITIVE AND NEGATIVE CLONAL SELECTION. PRINCIPLES OF HISTOPHYSIOLOGY AND PHYSIOLOGY OF THE IMMUNE SYSTEM (INNATE AND ACQUIRED IMMUNITY, MOLECULAR MECHANISMS AND CLINICAL CORRELATIONS, IMMUNOTHERAPY RATIONALE).
MUSCLE TISSUE: SMOOTH, SKELETAL STRIATUM AND CARDIAC STRIATUM. MOLECULAR BASIS OF MUSCLE CONTRACTION.
NERVOUS TISSUE AND NEUROSIS. SYNAPSES: TRAINING AND ROLE. MOTIVE PLATE. PERIPHERAL NERVE STRUCTURE.
OF ALL TISSUES IT IS NECESSARY TO KNOW HISTOPHYSIOLOGY AND CLINICAL CORRELATIONS.
STEM CELLS: TYPES, NICHE, CLINICAL CORRELATIONS.
B) EMBRIOLOGY: REPRODUCTION. MOLECULAR MECHANISMS OF DEVELOPMENT. THE MALE AND FEMALE GONADS. GAMETOGENESIS. FERTILIZATION. PREPARATION FOR NESTING. FIRST AND SECOND WEEK OF DEVELOPMENT: SEGMENTATION, FORMATION OF THE EMBRYONIC AREA.
THIRD WEEK: GASTRULATION, PRIMARY EMT. NOTOCHORD.
FOURTH WEEK: FOLDING OF THE EMBRYO AND DELIMITATION OF THE EMBRYONIC AREA.
EVOLUTION OF THE ECTODERM: FORMATION OF THE NEURAL TUBE. PRIMARY, DEFINITIVE AND DERIVATIVE BRAIN VESICLES. PLACODES.
EVOLUTION OF THE MESODERM: SOMITES, INTERMEDIATE MESODERM, LATERAL MESODERM AND THEIR DERIVATIVES.
DEVELOPMENT OF THE UROGENITAL SYSTEM.
EVOLUTION OF THE ENDODERM: FORMATION OF THE PRIMITIVE INTESTINE AND ITS DIFFERENTIATION. CLOACA AND ITS DERIVATIONS. RESPIRATORY SYSTEM DEVELOPMENT.
PHARYNGEAL APPARATUS AND ITS DERIVATIVES. FACE DEVELOPMENT.
FORMATION OF BONES AND MUSCLES.
DEVELOPMENT OF THE CARDIOVASCULAR SYSTEM.
DEVELOPMENT OF EMBRYONIC ANNEXES.
DEVELOPMENTAL DEFECTS AND MALFORMATIONS OF ALL APPARATUSES AND SYSTEMS.
AT EACH STAGE OF DEVELOPMENT, IT IS NECESSARY TO KNOW THE GENES, PROCESSES AND MOLECULES INVOLVED.

	Teaching Methods
	THE COURSE IS DIVIDED INTO LESSONS (60 HOURS) AND EXERCISES ON IMAGES OF HISTOLOGICAL PREPARATIONS (24 HOURS). THE LECTURES WILL HAVE THE ACTIVE PARTICIPATION OF THE STUDENTS, WHO WILL ALSO DEVELOP TOPICS OF SPECIAL INTEREST WHICH THEY WILL PRESENT TO THE CLASS THROUGH MINI-SEMINARS. THE COURSE ALSO PROVIDES TUTORING FOR STUDENTS WHO NEED MORE HELP.

	Verification of learning
	THE ACHIEVEMENT OF THE TEACHING OBJECTIVES IS CERTIFIED BY PASSING AN EXAM, EXPRESSED WITH A SCORE OUT OF THIRTY. THE EXAM INCLUDES A WRITTEN TEST WHICH PASSING WILL ALLOW ACCESS TO AN ORAL EXAMINATION WHICH WILL HAVE THE PURPOSE OF ASSESSING THE DEGREE OF KNOWLEDGE ACQUIRED BY THE STUDENT IN BOTH HISTOLOGY AND HUMAN EMBRYOLOGY. THE STUDENT WILL HAVE TO DEMONSTRATE THE ABILITY TO RECOGNIZE AND DESCRIBE THE FUNDAMENTAL TISSUES STARTING FROM IMAGES AND THEIR VARIANTS AND TO HAVE UNDERSTOOD THE MECHANISMS OF CELL DIFFERENTIATION, CELL INTERACTIONS, HISTOGENESIS AND THEIR RELATIONSHIP WITH DISEASES. IN EMBRYOLOGY, HE MUST DEMONSTRATE KNOWLEDGE OF THE DEVELOPMENTAL STAGES AND THE MORPHOGENETIC MECHANISMS AND THEIR ALTERATIONS IN THE COURSE OF ONCOGENESIS AND OTHER DISEASES. THE EXAM IS AIMED AT ASSESSING THAT THE STUDENT KNOWS THE FUNDAMENTAL PRINCIPLES OF THE DISCIPLINE. THE MARK, EXPRESSED IN THIRTIETHS WITH POSSIBLE HONORS, WILL DEPEND ON THE MATURITY ACQUIRED ON THE COURSE CONTENT. FOR THE PURPOSE OF AWARDING THE HONORS, THE QUALITY OF THE ORAL EXPOSURE WILL BE TAKEN INTO ACCOUNT, IN TERMS OF THE USE OF APPROPRIATE SCIENTIFIC LANGUAGE AND THE AUTONOMY OF JUDGMENT DEMONSTRATED.

Verification of learning

THE ACHIEVEMENT OF THE TEACHING OBJECTIVES IS CERTIFIED BY PASSING AN EXAM, EXPRESSED WITH A SCORE OUT OF THIRTY.
THE EXAM INCLUDES A WRITTEN TEST WHICH PASSING WILL ALLOW ACCESS TO AN ORAL EXAMINATION WHICH WILL HAVE THE PURPOSE OF ASSESSING THE DEGREE OF KNOWLEDGE ACQUIRED BY THE STUDENT IN BOTH HISTOLOGY AND HUMAN EMBRYOLOGY. THE STUDENT WILL HAVE TO DEMONSTRATE THE ABILITY TO RECOGNIZE AND DESCRIBE THE FUNDAMENTAL TISSUES STARTING FROM IMAGES AND THEIR VARIANTS AND TO HAVE UNDERSTOOD THE MECHANISMS OF CELL DIFFERENTIATION, CELL INTERACTIONS, HISTOGENESIS AND THEIR RELATIONSHIP WITH DISEASES. IN EMBRYOLOGY, HE MUST DEMONSTRATE KNOWLEDGE OF THE DEVELOPMENTAL STAGES AND THE MORPHOGENETIC MECHANISMS AND THEIR ALTERATIONS IN THE COURSE OF ONCOGENESIS AND OTHER DISEASES.
THE EXAM IS AIMED AT ASSESSING THAT THE STUDENT KNOWS THE FUNDAMENTAL PRINCIPLES OF THE DISCIPLINE. THE MARK, EXPRESSED IN THIRTIETHS WITH POSSIBLE HONORS, WILL DEPEND ON THE MATURITY ACQUIRED ON THE COURSE CONTENT. FOR THE PURPOSE OF AWARDING THE HONORS, THE QUALITY OF THE ORAL EXPOSURE WILL BE TAKEN INTO ACCOUNT, IN TERMS OF THE USE OF APPROPRIATE SCIENTIFIC LANGUAGE AND THE AUTONOMY OF JUDGMENT DEMONSTRATED.

	Texts
	A.A. VARI “ISTOLOGIA DI V. MONESI” VII EDIZIONE, PICCIN EDITORE G. PAPACCIO - V. TIRINO “ATLANTE DI ISTOLOGIA” III EDIZIONE, IDELSON-GNOCCHI EDITORE DE FELICI ET AL. “EMBRIOLOGIA UMANA” III EDIZIONE, PICCIN EDITORE FOR CONSULATION: T.W. SADLER “EMBRIOLOGIA MEDICA DI LANGMAN” VII EDIZIONE, EDRA EDITORE LARSEN “EMBRIOLOGIA UMANA” VI EDIZIONE, EDRA EDITORE ROSS-PAWLINA “ISTOLOGIA - TESTO E ATLANTE CON ELEMENTI DI BIOLOGIA CELLULARE E MOLECOLARE” II EDIZIONE, CASA EDITRICE AMBROSIANA

Texts

A.A. VARI “ISTOLOGIA DI V. MONESI” VII EDIZIONE, PICCIN EDITORE
G. PAPACCIO - V. TIRINO “ATLANTE DI ISTOLOGIA” III EDIZIONE, IDELSON-GNOCCHI EDITORE
DE FELICI ET AL. “EMBRIOLOGIA UMANA” III EDIZIONE, PICCIN EDITORE
FOR CONSULATION:
T.W. SADLER “EMBRIOLOGIA MEDICA DI LANGMAN” VII EDIZIONE, EDRA EDITORE
LARSEN “EMBRIOLOGIA UMANA” VI EDIZIONE, EDRA EDITORE
ROSS-PAWLINA “ISTOLOGIA - TESTO E ATLANTE CON ELEMENTI DI BIOLOGIA CELLULARE E MOLECOLARE” II EDIZIONE, CASA EDITRICE AMBROSIANA

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Federica PAPACCIO | HISTOLOGY AND HUMAN EMBRYOLOGY

HISTOLOGY AND HUMAN EMBRYOLOGY

PERCORSO SHARED STUDY PATHWAY

TEACHING UNITS

PROFESSORS

EXAMS

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Federica PAPACCIO | HISTOLOGY AND HUMAN EMBRYOLOGY