Carmine OSTACOLO | Curriculum

WORK EXPERIENCES
- Associate Professor in Medicinal Chemistry, SSD CHEM-07/A
Department of Pharmacy, University of Salerno [ 01/12/2022 – current]
City: Fisciano (SA) | Country: Italy
Medicinal Chemistry research. Design and synthesis of pharmacologically active molecules. Pharmacokinetic studies. In silico and Innovative methods in Medicinal Chemistry. Bioactive molecules from natural sources, particularly food matrices. Teaching and mentoring.
Lecturer for the course in "Drug qualitative Analysis" for the degree in Pharmacy
Lecturer for the course in "Medicinal Chemistry" for the degree in Herbal Products
Lecturer for the course in "Characterization and Valorization of local fruits and horticultural products of Regione Campania" for the degree in Innovation for the Mediterranean Agricultural Production-
- Lecturer
University of Messina, PhD course in Cehmical Sciences [ 05/06/2023 – 19/06/2023 ]
City: Messina | Country: Italy
Teaching course in “Metabolomics : a new multidisciplinary approach to sceintific research”
- Associate Professor in Medicinal Chemistry, SSD CHEM-07/A
Department of Pharmacy, University of Naples Federico II [ 31/12/2021 – 30/09/2022]
City: Naples | Country: Italy
Medicinal Chemistry research. Design and synthesis of pharmacologically active molecules. Pharmacokinetic studies. In silico and Innovative methods in Medicinal Chemistry. Bioactive molecules from natural sources, particularly food matrices. Teaching and mentoring.
Lecturer for the course in "Chemical and toxicological Analysis" for the degree in Quality Control in the Pharmaceutical Industry
-Member of the Editorial Board for the International Journal of Molecular Sciences (IF 4.556)
[ 08/2019 – Current ]
-Member of the International research group InRePharma (International Research Group on Pharmacy) in the Department of Pharmacy of Reald University College, Valona, Albania
[ 15/07/2019 – Current ]
-Co-Guest Editor of the Special Issue "Voltage-Gated and TRP Ion Channels: Molecular Basis for
their Function, Misfunction, and Therapeutic Applications” for the International Journal of Molecular Sciences (IF 4.556)
[ 08/2019 – 12/2019 ]
-Lecturer
Department of Agricultural Sciences, University Mediterranea of Reggio Calabria [ 2016 – 2017 ]
City: Reggio Calabria | Country: Italy
Lecturer for the course in "Chemistry, quality and safety of the products from Mediterranean plant-based supply chain" for the II degree Master in "Implementation of the innovative methods in the Mediterranean plant-based supply chain"
- Lecturer
Department of Agricultural Sciences, University Mediterranea of Reggio Calabria [ 2016 – 2017 ]
City: Reggio Calabria | Country: Italy
Lecturer for the course in "Chemistry, quality and safety of the products from Mediterranean plant-based supply chain" for the II degree Master in "Bakery functional products" for the II degree Master in "New products and processes for the traditional and functional bakery products supply chain"
-Lecturer
Terina Foundation[ 2014 – 2014 ]
City: Lamezia Terme (CZ) | Country: Italy
Lecturer for the course of "Analytical methods for metabolomic fingerprinting", high-level educational training course "Food@life"
-Visiting researcher
Department of Pharmaceutical Sciences, University of Perugia [ 2012 – 2014 ]
City: Perugia | Country: Italy
Member of the research Unit in Flow Chemistry of Professor Antimo Gioiello
-Scientific Consultant
Procter&Gamble Italian Research Center [ 2009 – 2010 ]
City: Pescara | Country: Italy
External scientific consultant for the analytical tests
-Marie-Curie fellowship
Procter&Gamble Italian Research Center [ 2008 – 2010 ]
City: Pescara | Country: Italy
Member of the research unit responsible for the syntheis and characterization of polymeric bioadhesive materials in the frame of the VII European framework programme, Marie Curie Industry-Academia Partnerships and Pathways (IAPP). Project: “Transfer of knowledge in the field of blue biotechnology for the development of bio-inspired materials based on waterproof bioadhesive (Blue4Glue)”
-Academic Researcher in Medicinal Chemistry, SSD CHIM/08
Department of Pharmacy, University of Naples Federico II [01/11/2006– 30/12/2021]
City: Naples | Country: Italy
Medicinal Chemistry research. Design and synthesis of pharmacologically active molecules. Pharmacokinetic studies. In silico and Innovative methods in Medicinal Chemistry. Bioactive molecules from natural sources, particularly food matrices.
Lecturer for the academic course in "Eco-compatible processes in Medicinal Chemistry" for the degrees in Pharmacy and Chemistry and Pharmaceutical Technology
Lecturer for the academic course in "Drug Analysis I" for the degree in "Quality Control in the Pharmaceutical Industry"
Lecturer for the courses in "Cosmetic Technology and manufacturing I", "Cosmetic Technology and
manufacturing II" and "Formulation of cosmetic products" for the II degree Master in "Cosmetic Science and Technology".
Lecturer for the academic course in "Cosmetic technology and legislation" for the degrees in Pharmacy and Chemistry and Pharmaceutical Technology
Lecturer for the academic course in "Drug Analysis II" for the degree in "Quality Control in the Pharmaceutical Industry"

-Research fellow
Department of Pharmacy, University of Naples Federico II [2001 – 2003]
City: Naples | Country: Italy
Design, synthesis and conformational studies about urotensin-II human receptor ligands
-Research fellow
Dipartimento of Biomedical and Pharmaceutical Sciences, Universiy of Salerno [ 2000 – 2001 ]
City: Fisciano (SA) | Country: Italy
Chemical approach to the study of neuroreceptors. Design, synthesis and preliminary pharmacological evaluation of chemical probes for the characterization of the receptors

EDUCATION AND TRAINING
- National Scientific Habilitation to Full Professor, Ministry of Education and Research [ 06/12/2023 – Attuale ]
- PhD in Pharmaceutical Sciences, Department of Pharmacy, University of Naples Federico II [ 11/2001 – 11/2004 ]
- Summa cum laude Degree in Pharmaceutical Chemistry and Technology, Department of Pharmacy, University of Naples Federico II [ 11/1994 – 03/2000 ]

DIGITAL SKILLS
Microsoft office(WordExcel Powerpoint Outlook) / Adobe Suite (Adobe Photoshop Adobe Indesign Adobe Illustrator) / Video Conferencing (Zoom Skype Google Hangout) / Social Media Management (Facebook Twitter Linkedin YouTube Instagram) / ChemDraw Ultra 120 / Anydesk / Reference Management softwares Zotero EndNote Mendeley / MNova MestreLab / Excellent command of bibliographic databases (SciFinder Reaxys Scholar)

PUBLICATIONS
Carmine Ostacolo has authored 76 papers in peer reviewed, indexed journals with an H-index of 25 (font Scopus, lastly accessed in 26/11/2024). The full list can be found at the following address: https://www.scopus.com/cto2/main.uri?origin=resultslist&stateKey=CTOF_1735207501

FUNDED PROJECTS
- Synthesis of Kv7.2/7.3 channel modulators: pharmacokinetic and pharmacodynamic optimization by medicinal chemistry approaches - Special K, European Union - Next Generation EU, Project PE00000006, Spoke 3: Neuronal Homeostasis and brain environment interaction. Principal investigator

-ISIDORe calls for infectious disease outbreak research 2022 (ISIDORe European infrastructure consortium) Project ID: 22249. Principal Investigator
- PRIN 2022 PNRR: Targeting rare epileptic encephalopathies: design and preclinical development of KCNT1 modulators (TELOS). Principal Investigator
-Approcci innovativi allo studio di patogenesi, modelli, terapie e percorsi assistenziali in malattie rare neuropsichiatriche, neuromuscolari e sensoriali – NEURORARE. Research Unit responsible
- Progetto FRA 2020- Identificazione di nuovi modulatori selettivi per i canali Kv 7.2/7.3 mediante
screening di librerie molecolari (IdentiKHit). Principal Investigator

- NVIDIA GPU Grant 2019. Development of in-silico methods to explore combinatorial peptide libraries. Principal investigator

- The cacao/chocolate supply-chain in Ecuador and other south-American countries. Principal investigator

- STAR programme 2016: "Identification of a Novel Kv7 channel activators and evaluation of their neuroprotective and anticonvulsivant efficacy". Coordinator of the synthetic and computational chemistry unit

- PRIN 2017 n. 2017ALCR7C_00 "Genetic epileptic channelopathies as disease models for drug discovery toward personalized treatment: an integrated bench-to-bedside and backward approach". Member of the research unit.

- NVIDIA Hardware Request Grant 2016. Pursuing the rational development of new TRPM8 modulators by molecular modeling studies. Principal Investigator

- PRIN 2012. Design and development of new agents for the treatment of parasitic diseases. Member of the research unit.

- PRIN 2009. Application of computational methdos to the development of new agents for the treatment of parasitic diseases. Member of the research unit.

- PRIN 2007: Development of new peptides and peptidomimetics as selective ligands of the Melanocortin receptor for the treatment of brain damage. Member of the research unit.

ORAL PRESENTATIONS
- Food peptidomics: decrypting natural products to hunt the buried pharmaceutical value.
[28/04/2022] Invited lecture. Sustainable practices in Medicinal Chemistry (SUPRAMED) 2022, Palermo, Italy
- Design and preclinical development of CP86, a new potent antiepileptic drug [ 19/06/2022 – 23/06/2022 ] SEQT 2022, Santiago de Compostela, Spagna
- Discovery of CP86, a potent in vivo antiepileptic drug [ 14/09/2021 – 23/09/2021 ] XXVII Congresso Nazionale della Società Chimica Italiana. Online
- Mapping Kv7.3 binding site by in silico driven structure based approach [ 12/09/2019 – 14/09/2019 ] International Symposium on Kv7 channels. Napoli, Italy
- TRPM8 channel modulators: identification of a selective superantagonist by structural simplification and hit refinement approaches [ 16/07/2019 – 19/07/2019 ] XII Simposio dei giovani Chimici Farmaceutici (NPCF 12). Milano, Italy
- Development of TRPM8 ion channel modulators: from design to therapeutic applications by multidisciplinary approach
[ 22/05/2019 – 23/05/2019 ] Conferenza scientifica Internazionale 'Innovation practices and technological transfer in pharmaceutical sciences'. Valona, Albania
- Bioadhesive peptides, from marine mussels to solid-phase synthesis [ 27/10/2011 – 29/10/2011 ] International workshop ‘Biobased and bioinspired materials’. Bremen, Germany
- Synthesis, hydrolysis and skin accumulation of alpha-tocopherol esters as new dermal prodrugs [ 19/10/2005 – 21/10/2005 ] World Congress New technologies in preventing photoinduced skin cancer and photoaging. Siena, Italy

PATENTS AND TECHNOLOGICAL TRANSFER
- Cofounder and member of the spin-off consortium SONDA srl [13/10/2022 - Current]
- Modulators of potassium ion channels and uses thereof
[ 06/08/2020 ]
Patent Number WO2020157126A1
- Cosmetic compositions containing a combination of natural active ingredients
[ 20/07/2016 ]
Patent number EP3043770 (A1), also published as ITMI20131479 (A1) e WO2015033316 (A1)
- Polyethylene glycol derivatives of palmitoylethnolamides and analogous acylethanolamides
[ 11/06/2015 ]
Brevetto numero US2015157733 (A1)
- Aminoacid adducts for percutaneous delivery of vitamin B3
[ 07/06/2007 ]
Patent Number WO2007064762 (A2) also published as WO2007064762 (A3), EP1792630 (A1) e
US2007128145 (A1).
- Cofounder and member of the spin-off consortium FAST-linking srl
[ 29/03/2012 – 30/07/2022 ]
PI of the R&D unit
- Thir parties activities [ 2007 – Current ]
Scientific consultant for different National and International enterprises: Procter&Gamble Italia (Pescara), Kosmedica srl (Pozzuoli, NA), Gruppo Farmaimpresa (Teverola, CE), Miara srl (Roma), GLC cosmetici sas (Chiusa Sclafani, PA), Aesthelab srl (Pozzuoli, NA), ADM94 srl (S. Giuliano Milanese, MI), Cleiry snc (Napoli), RCA srl (Latina), Elemed srl (Napoli), Epitech group spa (Milano), IROS RC srl (Napoli), CXL OPHTHALMICS LLC (USA).