Carmine OSTACOLO | PHARMACOLOGY AND PHARMACEUTICS PRINCIPLES

cod. 0712100017

PHARMACOLOGY AND PHARMACEUTICS PRINCIPLES

	0712100017
	DIPARTIMENTO DI FARMACIA
	EQF6
	HERBAL SCIENCE
	2024/2025

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 3
	YEAR OF DIDACTIC SYSTEM 2020
	FULL ACADEMIC YEAR

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	FARMACOLOGIA GENERALE MODULO DI PRINCIPI DI FARMACOLOGIA E CHIMICA FARMACEUTICA
	BIO/14	6	48	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
2	CHIMICA FARMACEUTICA E TOSSICOLOGICA MODULO DI PRINCIPI DI FARMACOLOGIA E CHIMICA FARMACEUTICA
	CHIM/08	6	48	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	CARMINE OSTACOLO2 T Curriculum
	ADA POPOLO1 Curriculum

	Objectives
	THE AIM OF THIS CLASS IS TO PROVIDE STUDENTS WITH THE KNOWLEDGE OF THE CHEMICAL BASES THAT EFFECT THE ACTIVITIES OF THE DRUGS BOTH AS REGARDS THE PHARMACOKINETIC THAT THE PHARMACODYNAMIC PROPERTIES. THE CLASS ALSO AIMS TO PROVIDE THE BASIS FOR UNDERSTANDING CHEMICAL PROPERTIES OF SELECTED CLASSES OF DRUGS EITHER OF SYNTHETIC OR NATURAL ORIGIN. KNOWLEDGE AND UNDERSTANDING TO KNOW AND UNDERSTAND THE MECHANISM OF ACTION AND PHARMACOKINETICS OF DRUGS USED IN HUMAN PATHOLOGIES. APPLYING KNOWLEDGE AND UNDERSTANDING TO BE ABLE TO APPLY THE ACQUIRED KNOWLEDGE ABOUT THE MECHANISM OF DRUG ACTION FOR THE MANAGEMENT OF HUMAN PATHOLOGIES AS WELL AS THE EVALUATION OF INTERACTIONS AND ADVERSE REACTIONS. MAKING JUDGMENTS TO BE ABLE TO COMBINE OLD AND NEW INFORMATION IN ORDER TO APPLY PHARMACOLOGICAL PROGRESS IN THERAPY COMMUNICATION SKILLS ABILITY TO TRANSFER CLEARLY THE ACQUIRED DRUG INFORMATION TO THE SPECIALIST AS WELL AS TO THE LAY PEOPLE. LEARNING SKILLS ABILITY TO UPDATE DRUG INFORMATION THROUGH CONTINUOUS USE OF TEXTBOOKS, SCIENTIFIC PAPERS, DATA FROM DRUG REGULATORY AGENCIES.

THE AIM OF THIS CLASS IS TO PROVIDE STUDENTS WITH THE KNOWLEDGE OF THE CHEMICAL BASES THAT EFFECT THE ACTIVITIES OF THE DRUGS BOTH AS REGARDS THE PHARMACOKINETIC THAT THE PHARMACODYNAMIC PROPERTIES. THE CLASS ALSO AIMS TO PROVIDE THE BASIS FOR UNDERSTANDING CHEMICAL PROPERTIES OF SELECTED CLASSES OF DRUGS EITHER OF SYNTHETIC OR NATURAL ORIGIN.
KNOWLEDGE AND UNDERSTANDING
TO KNOW AND UNDERSTAND THE MECHANISM OF ACTION AND PHARMACOKINETICS OF DRUGS USED IN HUMAN PATHOLOGIES.
APPLYING KNOWLEDGE AND UNDERSTANDING
TO BE ABLE TO APPLY THE ACQUIRED KNOWLEDGE ABOUT THE MECHANISM OF DRUG ACTION FOR THE MANAGEMENT OF HUMAN PATHOLOGIES AS WELL AS THE EVALUATION OF INTERACTIONS AND ADVERSE REACTIONS.
MAKING JUDGMENTS
TO BE ABLE TO COMBINE OLD AND NEW INFORMATION IN ORDER TO APPLY PHARMACOLOGICAL PROGRESS IN THERAPY
COMMUNICATION SKILLS
ABILITY TO TRANSFER CLEARLY THE ACQUIRED DRUG INFORMATION TO THE SPECIALIST AS WELL AS TO THE LAY PEOPLE.
LEARNING SKILLS
ABILITY TO UPDATE DRUG INFORMATION THROUGH CONTINUOUS USE OF TEXTBOOKS, SCIENTIFIC PAPERS, DATA FROM DRUG REGULATORY AGENCIES.

	Prerequisites
	THE ACQUISITION OF THE CONTENT RELATING TO THE FOLLOWING DISCIPLINES IS REQUIRED: FARMACOLOGIA GENERALE: ANATOMY, PHYSIOLOGY AND PATHOLOGY MEDICINAL CHEMISTRY: GENERAL CHEMISTRY, ORGANIC CHEMISTRY, AND THOSE REQUIRED FOR FARMACOLOGIA GENERALE

	Contents
	MODULE OF PRINCIPI DI CHIMICA FARMACEUTICA - DRUGS AND TARGETS FOR DRUGS: DEFINITIONS AND GENERAL (2 HOURS; 0.25 CFU) - ENZYMES AS DRUG TARGETS. (2 HOURS; 0.25 CFU) -RECEPTORS AS DRUG TARGETS: THE DESIGN OF AGONISTS. THE DESIGN OF ANTAGONISTS. PARTIAL AGONISTS. REVERSE AGONISTS. (4 HOURS; 0.5 CFU) - NUCLEIC ACIDS AS DRUG TARGETS (2 HOURS; 0.25 CFU) -FROM BOTANICALS TO DRUGS. (16 HOURS; 2 CFU) -ADMINISTRATION OF DRUGS. (2 HOURS; 0.25 CFU) - HYPERTENSION AND ANTI-HYPERTENSIVE DRUGS: DEFINITIONS AND GENERAL. CLASSIFICATION, STRUCTURES, MECHANISM OF ACTION, CORRELATION STRUCTURE OF ACTIVITIES, PHARMACOKINETICS AND PHARMACODYNAMICS. (6 HOURS; 0.75 CFU) -DIABETES AND ANTIDIABETIC DRUGS: DEFINITIONS AND GENERAL. CLASSIFICATION, STRUCTURES, MECHANISM OF ACTION, CORRELATION STRUCTURE OF ACTIVITIES, PHARMACOKINETICS AND PHARMACODYNAMICS. COMPARISON WITH PHYTOTHERAPY AND INTERACTIONS WITH NATURAL ACTIVE INGREDIENTS. (6 HOURS; 0.75 CFU) - ANALGESIC OPIOIDS. DEFINITIONS AND GENERAL. CLASSIFICATION, STRUCTURES, MECHANISM OF ACTION, CORRELATION STRUCTURE OF ACTIVITIES, PHARMACOKINETICS AND PHARMACODYNAMICS. COMPARISON WITH PHYTOTHERAPY AND INTERACTIONS WITH NATURAL ACTIVE COMPOUNDS. (6 HOURS; 0.75 CFU) - DISMETABOLIC DISEASES AND HYPERCHOLESTEROLEMIA. DEFINITIONS AND GENERAL. COMPARISON WITH PHYTOTHERAPY AND INTERACTIONS WITH NATURAL ACTIVE COMPOUNDS. (2 HOURS; 0.25 CFU) -PHARMACOKINETICS: ROUTES OF ADMINISTRATION (4 HOURS; 0.5 CFU). ABSORPTION (4 HOURS; 0.5 CFU). DISTRIBUTION (2 HOURS; 0.25 CFU). METABOLISM (2 HOURS; 0.25 CFU). EXCRETION (2 HOURS; 0.25 CFU). -PHARMACODYNAMICS: INTERACTION DRUG/RECEPTOR. AGONIST. PD2. ANTAGONIST. PA2. PARTIAL AGONIST/ANTAGONIST. TRANSDUCTION OF DRUG/RECEPTOR INTERACTION. IONOTROPIC RECEPTORS. METABOTROPIC RECEPTORS. VOLTAGE-GATED ION CHANNELS. INTRACELLULAR RECEPTORS. RECEPTORS FOR GROWTH FACTORS. INTRACELLULAR TRANSDUCTION MECHANISMS. CALCIUM HOMEOSTASIS. PHARMACODYNAMIC INTERACTIONS. (18 HOURS; 2.25 CFU) -PHARMACOTHERAPY: ACE INHIBITORS AND SARTANS (2 ORE; 0.25 CFU). CARDIOTONIC AGENTS (2 ORE; 0.25 CFU). HEPARIN AND WARFARIN (2 ORE; 0.25 CFU). INFLAMMATION. NSAIDS. ACETAMINOPHEN (2 ORE; 0.25 CFU). GLUCOCORTICOIDS (2 ORE; 0.25 CFU). INSULIN (2 ORE; 0.25 CFU). BENZODIAZEPINE (2 ORE; 0.25 CFU). OPPIOIDS (2 ORE; 0.25 CFU).

Contents

MODULE OF PRINCIPI DI CHIMICA FARMACEUTICA
- DRUGS AND TARGETS FOR DRUGS: DEFINITIONS AND GENERAL (2 HOURS; 0.25 CFU)
- ENZYMES AS DRUG TARGETS. (2 HOURS; 0.25 CFU)
-RECEPTORS AS DRUG TARGETS: THE DESIGN OF AGONISTS. THE DESIGN OF ANTAGONISTS. PARTIAL AGONISTS. REVERSE AGONISTS. (4 HOURS; 0.5 CFU)
- NUCLEIC ACIDS AS DRUG TARGETS (2 HOURS; 0.25 CFU)
-FROM BOTANICALS TO DRUGS. (16 HOURS; 2 CFU)
-ADMINISTRATION OF DRUGS. (2 HOURS; 0.25 CFU)
- HYPERTENSION AND ANTI-HYPERTENSIVE DRUGS: DEFINITIONS AND GENERAL. CLASSIFICATION, STRUCTURES, MECHANISM OF ACTION, CORRELATION STRUCTURE OF ACTIVITIES, PHARMACOKINETICS AND PHARMACODYNAMICS. (6 HOURS; 0.75 CFU)
-DIABETES AND ANTIDIABETIC DRUGS: DEFINITIONS AND GENERAL. CLASSIFICATION, STRUCTURES, MECHANISM OF ACTION, CORRELATION STRUCTURE OF ACTIVITIES, PHARMACOKINETICS AND PHARMACODYNAMICS. COMPARISON WITH PHYTOTHERAPY AND INTERACTIONS WITH NATURAL ACTIVE INGREDIENTS. (6 HOURS; 0.75 CFU)
- ANALGESIC OPIOIDS. DEFINITIONS AND GENERAL. CLASSIFICATION, STRUCTURES, MECHANISM OF ACTION, CORRELATION STRUCTURE OF ACTIVITIES, PHARMACOKINETICS AND PHARMACODYNAMICS. COMPARISON WITH PHYTOTHERAPY AND INTERACTIONS WITH NATURAL ACTIVE COMPOUNDS. (6 HOURS; 0.75 CFU)
- DISMETABOLIC DISEASES AND HYPERCHOLESTEROLEMIA. DEFINITIONS AND GENERAL. COMPARISON WITH PHYTOTHERAPY AND INTERACTIONS WITH NATURAL ACTIVE COMPOUNDS. (2 HOURS; 0.25 CFU)

-PHARMACOKINETICS: ROUTES OF ADMINISTRATION (4 HOURS; 0.5 CFU). ABSORPTION (4 HOURS; 0.5 CFU). DISTRIBUTION (2 HOURS; 0.25 CFU). METABOLISM (2 HOURS; 0.25 CFU). EXCRETION (2 HOURS; 0.25 CFU).
-PHARMACODYNAMICS: INTERACTION DRUG/RECEPTOR. AGONIST. PD2. ANTAGONIST. PA2. PARTIAL AGONIST/ANTAGONIST. TRANSDUCTION OF DRUG/RECEPTOR INTERACTION. IONOTROPIC RECEPTORS. METABOTROPIC RECEPTORS. VOLTAGE-GATED ION CHANNELS. INTRACELLULAR RECEPTORS. RECEPTORS FOR GROWTH FACTORS. INTRACELLULAR TRANSDUCTION MECHANISMS. CALCIUM HOMEOSTASIS. PHARMACODYNAMIC INTERACTIONS. (18 HOURS; 2.25 CFU)
-PHARMACOTHERAPY: ACE INHIBITORS AND SARTANS (2 ORE; 0.25 CFU). CARDIOTONIC AGENTS (2 ORE; 0.25 CFU). HEPARIN AND WARFARIN (2 ORE; 0.25 CFU). INFLAMMATION. NSAIDS. ACETAMINOPHEN (2 ORE; 0.25 CFU). GLUCOCORTICOIDS (2 ORE; 0.25 CFU). INSULIN (2 ORE; 0.25 CFU). BENZODIAZEPINE (2 ORE; 0.25 CFU). OPPIOIDS (2 ORE; 0.25 CFU).

	Teaching Methods
	MODULE OF PRINCIPI DI CHIMICA FARMACEUTICA THE COURSE INCLUDES 48 HOURS OF ASSISTED TEACHING (6 CFU). POWERPOINT AS A VISUAL AID WILL BE USED FOR LECTURES AND ALL THE TOPICS OF THE COURSE PROGRAM WILL BE ADDRESSED. ATTENDANCE OF LECTURES IN CLASSROOM IS MANDATORY. IN ORDER TO TAKE THE FINAL EXAM, THE STUDENT MUST HAVE ATTENDED AT LEAST 70% OF THE HOURS PROVIDED BY FRONTAL TEACHING. THE PRESENCE CHECKING MODE IS GENERALLY ELECTRONIC TYPE (EASYCOURSE) MODULE OF PRINCIPI DI FARMACOLOGIA: LECTURES.

Teaching Methods

MODULE OF PRINCIPI DI CHIMICA FARMACEUTICA
THE COURSE INCLUDES 48 HOURS OF ASSISTED TEACHING (6 CFU). POWERPOINT AS A VISUAL AID WILL BE USED FOR LECTURES AND ALL THE TOPICS OF THE COURSE PROGRAM WILL BE ADDRESSED. ATTENDANCE OF LECTURES IN CLASSROOM IS MANDATORY. IN ORDER TO TAKE THE FINAL EXAM, THE STUDENT MUST HAVE ATTENDED AT LEAST 70% OF THE HOURS PROVIDED BY FRONTAL TEACHING. THE PRESENCE CHECKING MODE IS GENERALLY ELECTRONIC TYPE (EASYCOURSE)

MODULE OF PRINCIPI DI FARMACOLOGIA:
LECTURES.

	Verification of learning
	THE LEARNING OBJECTIVES ARE VERIFIED BY PASSING AN EXAM WITH EVALUATION IN THIRTIETHS. FOR THE PHARMACOLOGY MODULE THE ORAL TEST CONSISTS OF AN INTERVIEW WITH QUESTIONS AND DISCUSSION ON THE PROGRAM LASTING ABOUT 15 MINUTES. THE ORAL TEXT IS FINALIZED IN ASSESSING THE LEVEL OF KNOWLEDGE AND UNDERSTANDING REACHED BY THE STUDENT ON THE CONTENTS OF THE ENTIRE COURSE AND TO VERIFY THE CAPACITY OF EXPOSURE USING APPROPRIATE TERMINOLOGY AND THE ABILITY TO AUTONOMOUSLY MANAGE THE THEORETICAL TOPICS. THE TEST IS EVALUATED IN THIRTIETHS AND IS PASSED WITH THE MINIMUM GRADE OF 18/30. FOR THE MEDICINAL CHEMISTRY MODULE, THE FINAL TEST IS BASED ON A MANDATORY WRITTEN TEST FOLLOWED BY OPTIONAL (STUDENT CHOICE) ORAL TEST, TAKING PALCE IN DIFFERENT SCHEDULED DAYS. THE WRITTEN TEST CONSISTS OF 4 OPEN-ENDED QUESTIONS CONCERNING THE ENTIRE PROGRAMME. THE ORAL TEST CONSISTS OF AN INTERVIEW OF ABOUT 15 MINUTES FINALIZED IN ASSESSING THE LEVEL OF KNOWLEDGE AND UNDERSTANDING REACHED BY THE STUDENT ON THE CONTENTS OF THE ENTIRE COURSE AND TO VERIFY THE CAPACITY OF EXPOSURE USING APPROPRIATE TERMINOLOGY AND THE ABILITY TO AUTONOMOUSLY MANAGE THE THEORETICAL TOPICS. THE EXAM IS EVALUATED IN THIRTIETHS AND IS CONSIDERED PASSED WITH THE MINIMUM GRADE OF 18/30. FOR THE MEDICINAL CHEMISTRY MODULE, AT THE END OF THE FIRST HALFSEMESTER (MIDDEL OF APRIL) AND AT THE END OF THE SEMESTER (END OF MAY) , TWO PARTIAL TESTS (PIIT) WILL BE ADMINISTERED, AS WRITTEN TEST (2 HOURS LASTING) ALSO WITH AN EVALUATION IN THIRTIETHS. PASSING THE PARTIAL TESTS EXEMPTS THE STUDENT FROM THE MANDATORY WRITTEN FINAL TEST; THE FINAL RESULTS OF THE TWO PARTIAL TESTS WILL BE THE MATHEMATICAL AVERAGE. THE EXEMPTION IS VALID THROUGH ALL THE FOLLOWING SEMESTER.

Verification of learning

THE LEARNING OBJECTIVES ARE VERIFIED BY PASSING AN EXAM WITH EVALUATION IN THIRTIETHS. FOR THE PHARMACOLOGY MODULE THE ORAL TEST CONSISTS OF AN INTERVIEW WITH QUESTIONS AND DISCUSSION ON THE PROGRAM LASTING ABOUT 15 MINUTES. THE ORAL TEXT IS FINALIZED IN ASSESSING THE LEVEL OF KNOWLEDGE AND UNDERSTANDING REACHED BY THE STUDENT ON THE CONTENTS OF THE ENTIRE COURSE AND TO VERIFY THE CAPACITY OF EXPOSURE USING APPROPRIATE TERMINOLOGY AND THE ABILITY TO AUTONOMOUSLY MANAGE THE THEORETICAL TOPICS. THE TEST IS EVALUATED IN THIRTIETHS AND IS PASSED WITH THE MINIMUM GRADE OF 18/30.
FOR THE MEDICINAL CHEMISTRY MODULE, THE FINAL TEST IS BASED ON A MANDATORY WRITTEN TEST FOLLOWED BY OPTIONAL (STUDENT CHOICE) ORAL TEST, TAKING PALCE IN DIFFERENT SCHEDULED DAYS. THE WRITTEN TEST CONSISTS OF 4 OPEN-ENDED QUESTIONS CONCERNING THE ENTIRE PROGRAMME. THE ORAL TEST CONSISTS OF AN INTERVIEW OF ABOUT 15 MINUTES FINALIZED IN ASSESSING THE LEVEL OF KNOWLEDGE AND UNDERSTANDING REACHED BY THE STUDENT ON THE CONTENTS OF THE ENTIRE COURSE AND TO VERIFY THE CAPACITY OF EXPOSURE USING APPROPRIATE TERMINOLOGY AND THE ABILITY TO AUTONOMOUSLY MANAGE THE THEORETICAL TOPICS. THE EXAM IS EVALUATED IN THIRTIETHS AND IS CONSIDERED PASSED WITH THE MINIMUM GRADE OF 18/30.
FOR THE MEDICINAL CHEMISTRY MODULE, AT THE END OF THE FIRST HALFSEMESTER (MIDDEL OF APRIL) AND AT THE END OF THE SEMESTER (END OF MAY) , TWO PARTIAL TESTS (PIIT) WILL BE ADMINISTERED, AS WRITTEN TEST (2 HOURS LASTING) ALSO WITH AN EVALUATION IN THIRTIETHS. PASSING THE PARTIAL TESTS EXEMPTS THE STUDENT FROM THE MANDATORY WRITTEN FINAL TEST; THE FINAL RESULTS OF THE TWO PARTIAL TESTS WILL BE THE MATHEMATICAL AVERAGE. THE EXEMPTION IS VALID THROUGH ALL THE FOLLOWING SEMESTER.

	Texts
	THOMAS L. LEMKE, DAVID A. WILLIAMS FOYE - FOYE’S PRINCIPI DI CHIMICA FARMACEUTICA- PICCIN FARMACOLOGIA GENERALE: CLEMENTI & FUMAGALLI, FARMACOLOGIA GENERALE E MOLECOLARE. UTET, TORINO (3A EDIZIONE). H.P. RANG, M.M. DALE, D.M. RITTER, FARMACOLOGIA. EDITRICE AMBROSIANA. B.G. KATZUNG, FARMACOLOGIA GENERALE E CLINICA. PICCIN (6A EDIZIONE).

Lessons Timetable

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Carmine OSTACOLO | PHARMACOLOGY AND PHARMACEUTICS PRINCIPLES