Pasquale LONGO | BIOINORGANIC CHEMISTRY
Pasquale LONGO BIOINORGANIC CHEMISTRY
cod. 0522300055
BIOINORGANIC CHEMISTRY
| 0522300055 | |
| DEPARTMENT OF CHEMISTRY AND BIOLOGY "ADOLFO ZAMBELLI" | |
| EQF7 | |
| CHEMISTRY | |
| 2024/2025 |
| OBBLIGATORIO | |
| YEAR OF COURSE 1 | |
| YEAR OF DIDACTIC SYSTEM 2016 | |
| SPRING SEMESTER |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| CHIM/03 | 5 | 40 | LESSONS | |
| CHIM/03 | 1 | 12 | EXERCISES |
| Objectives | |
|---|---|
| GENERAL OBJECTIVE. THE COURSE AIMS TO DEEPEN KNOWLEDGE OF ADVANCED INORGANIC CHEMISTRY WITH PARTICULAR REFERENCE TO THE ESSENTIALITY OF METALS FOR BIOLOGICAL PROCESSES AND THE USE OF METAL COMPLEXES IN CLINICAL DIAGNOSTICS AND THERAPY, AS WELL AS SUITABLE LIGANDS TO REMOVE TOXIC ELEMENTS. KNOWLEDGE AND UNDERSTANDING. THE COURSE AIMS TO PROVIDE ADVANCED KNOWLEDGE OF BIO-INORGANIC CHEMISTRY WITH PARTICULAR REFERENCE TO THE USE OF METAL COMPOUNDS IN DIAGNOSTICS AND CLINICAL THERAPY. ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING. THE COURSE WILL MAKE THE STUDENT PARTICULARLY INTERESTED IN ORGANOMETALLIC CHEMISTRY ALREADY TREATED DIFFERENTLY IN OTHER ADVANCED INORGANIC CHEMISTRY COURSES, HAVING THE OPPORTUNITY TO DISCOVER A SERIES OF APPLICATION AND IMPLICATIONS OF THE METALS IN MEDICINE. AUTONOMY OF JUDGEMENT. STUDENTS WILL BE GUIDED TO LEARN IN A CRITICAL AND RESPONSIBLE MANNER EVERYTHING THAT IS PROPOSED DURING THE LESSONS AND TO ENRICH THEIR JUDGMENT SKILLS ALSO THROUGH THE DEVELOPMENT OF A TOPIC INDICATED BY THE TEACHER AND THROUGH QUESTIONS AND DISCUSSIONS ON THE TOPICS OF THE COURSE WITH THE TEACHER HIMSELF. COMMUNICATION SKILLS. THE COURSE WILL TEND TO FAVOR THE STUDENT'S ABILITY TO CLEARLY AND RIGOROUSLY EXPLAIN THE KNOWLEDGE ACQUIRED, TAKING CARE OF BOTH THE HISTORICAL ASPECTS AND THE FUTURE PROSPECTS FOR THE USE OF METAL COMPLEXES IN CHEMOTHERAPY AND DIAGNOSTICS. LEARNING ABILITY THE STUDENT WILL BE ABLE TO USE TRADITIONAL BIBLIOGRAPHIC TOOLS AND IT RESOURCES TO CARRY OUT RESEARCH ON RECENT TECHNICAL AND SCIENTIFIC LITERATURE IN BIOLOGICAL CONTEXT RELATING TO A PARTICULAR METAL CHOSEN BY THE TEACHER FOR EACH STUDENT. |
| Prerequisites | |
|---|---|
| NO PREREQUISITES |
| Contents | |
|---|---|
| OVERVIEW OF BIOINORGANIC CHEMISTRY. WHAT IS BIOINORGANIC CHEMISTRY? PRINCIPLE OF COORDINATION CHEMISTRY RELATED TO BIOINORGANIC CHEMISTRY. THE CHELATE EFFECT , PKA VALUES OF COORDINATED LIGANDS, LIGAND EXCHANGE RATES, ELECTRONIC AND GEOMETRIC STRUCTURES OF METAL IONS IN BIOLOGY. PROPERTIES OF BIOLOGICAL MOLECULES. PROTEINS AND THEIR COSTITUENTS. PROTEINS AS LIGANDS. THE KINETIC ANALYSIS OF ENZYME REACTIONS. NUCLEIC ACIDS AND THEIR COSTITUENTS. RNA, DNA AND THEIR COSTITUENTS BLOCKS. METAL BINDING AND NUCLEIC ACID STRUCTURE. PROSTHETIC GROUPS. UPTAKE OF METAL CONTAINING UNITS IN BIOLOGY. BIOAVAILABILITY OF METAL IONS. ENRICHMENT STRATEGIES AND INTRACELLULAR CHEMISTRY OF METALS. SPONTANEOUS SELF-ASSEMBLY OF METAL CLUSTERS. CONTROL AND UTILIZATION OF METAL ION CONCENTRATION IN CELLS. AN EXAMPLE OF A BENEFICIAL METAL: IRON. METAL ION STABILIZATION OF PROTEIN AND NUCLEIC ACID STRUCTURE. PROTEIN BINDING TO METALLATED DNA: MECHANISM OF ACTION OF FEW ANTICANCER AGENTS. SELECTION AND INSERTION OF METAL IONS FOR PROTEIN SITES. METAL FUNCTIONS IN METALLOPROTEINS. ELECTRON-TRANSFER PROTEINS. SUBSTRATE BINDING AND ACTIVATION BY NONREDOX MECHANISMS. ATOM- AND GROUP-TRANSFER CHEMISTRY. PROTEIN TUNING OF METAL PROPERTIES TO ACHIEVE SPECIFIC FUNCTIONS. METALS IN MEDICINE. METAL COMPLEXES IN DIAGNOSIS AND CANCER THERAPY. SYNTHETIC POLYMERS AND BIOPOLYMERS AS CARRIERS OF METAL COMPLEXES: THE EPR EFFECT. |
| Teaching Methods | |
|---|---|
| TEACHING THE COURSE INCLUDES 48 HOURS OF LECTURES TO BE HELD IN CLASSROOM. TEACHING SUPPORTS INCLUDES THE CLASSIC BLACKBOARD AND SLIDES USING THE POWER POINT PROGRAM. ATTENDANCE OF LECTURES EX CATHEDRA ARE STRONGLY RECOMMENDED, ALSO WHY PARTS OF LESSONS REGARD RESEARCH TOPICS RECENTLY TREATED IN LITERATURE. |
| Verification of learning | |
|---|---|
| ORAL EXAM (VIVA VOCE EXAM) THE ORAL EXAMINATION SHOULD DETERMINE WHETHER THE STUDENT HAS ACQUIRED A DEEPER KNOWLEDGE OF THE FUNDAMENTAL CONCEPTS OF BIOINORGANIC CHEMISTRY AND OF THE MOST IMPORTANT MECHANISMS OF ACTION OF BIOLOGICAL PROCESSES INVOLVING INORGANIC ELEMENTS. |
| Texts | |
|---|---|
| - HAND OUTS - S.J. LIPPARD, J.M. BERG “PRINCIPLES OF BIOINORGANIC CHEMISTRY” - UNIVERSITY SCIENCE BOOKS. - W. KAIM, B. SCHWEDERSKI “BIOINORGANIC CHEMISTRY: INORGANIC ELEMENTS IN THE CHEMISTRY OF LIFE” - WILEY |
| More Information | |
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