Vincenzo VENDITTO | BIOMATERIALS

cod. 0522300058

BIOMATERIALS

	0522300058
	DEPARTMENT OF CHEMISTRY AND BIOLOGY "ADOLFO ZAMBELLI"
	EQF7
	CHEMISTRY
	2020/2021

CURRICULUM BIOMOLECULAR CHEMISTRY

	OBBLIGATORIO
	YEAR OF COURSE 1
	YEAR OF DIDACTIC SYSTEM 2016
	ANNUALE

TEACHING UNITS

SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
CHIM/04	10	80	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
CHIM/04	2	24	LAB	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	VINCENZO VENDITTO T Curriculum
	PAOLA RIZZO Curriculum

	Objectives
	MODULE 1 (RIZZO) BIOMATERIALS: CHEMICAL STRUCTURES AND PHYSICAL PROPERTIES THE COURSE AIMS TO DESCRIBE THE STRUCTURAL CHARACTERISTICS OF BIOMATERIALS AND THEIR PHYSICAL PROPERTIES. N DETAIL, THE CRYSTAL STRUCTURES OF METALS, ALLOYS, CERAMIC MATERIALS AND POLYMERIC MATERIALS WILL BE DESCRIBED. THE IMPERFECTIONS PRESENT IN SOLIDS, POINT DEFECTS AND DISLOCATIONS WILL BE DESCRIBED, HIGHLIGHTING HOW THEIR PRESENCE ALTERS THE PROPERTIES OF THE MATERIALS THEMSELVES, FOR EXAMPLE INCREASING THEIR RESISTANCE . THE MAIN TECHNIQUES OF CHARACTERIZATION OF THE MATERIALS WILL BE BRIEFLY INTRODUCED AND IN PARTICULAR THE TECHNIQUES FOR THE DETERMINATION OF THE CRYSTALLINE STRUCTURES OF SOLIDS AND THE MICROSCOPIC ONES AIMED FOR EXAMPLE AT THE DETERMINATION OF GRAIN SIZES WILL BE BRIEFLY DESCRIBED. PARTICULAR ATTENTION WILL BE PAID TO DESCRIBING HOW THE TRANSFORMATION OF THE MICROSTRUCTURE MODIFIES THE PROPERTIES OF THE MATERIALS THEMSELVES, SUCH AS THE THERMAL PROPERTIES (THERMAL CAPACITY, THERMAL EXPANSION, THERMAL CONDUCTIVITY) AND OPTICAL PROPERTIES. THE MAIN SKILLS DEVELOPED BY THE STUDENT WILL BE: - RECOGNIZE THE CHEMICAL-PHYSICAL AND STRUCTURAL PROPERTIES OF THE DIFFERENT BIOMATERIALS - CORRELATING THE PROPERTIES OF A BIOMATERIAL WITH POSSIBLE APPLICATIONS IN THE BIOMEDICAL FIELD MODULE 2 (VENDITTO) BIOMATERIALS: MEDICAL DEVICES AND THEIR INTERACTION WITH BIOLOGICAL SYSTEMS THE AIM OF THE COURSE IS TO DESCRIBE THE MOST WIDESPREAD AND USED MATERIALS FOR BIOMEDICAL APPLICATIONS. IN PARTICULAR, THE CHEMICAL AND PHYSICAL PROPERTIES INVOLVED IN THE INTERACTION WITH THE BIOLOGICAL SYSTEMS OF THESE MATERIALS WILL BE DESCRIBED. THE CLASSES OF MATERIALS USED IN MEDICINE (CERAMICS, METALS, POLYMERS, COMPOSITES) IN THEIR MOST WIDESPREAD APPLICATIONS WILL ALSO BE DESCRIBED. THE MOST IMPORTANT THERAPEUTIC DEVICES (ARTICULATION AND DENTAL PROSTHESES, CARDIOVASCULAR DEVICES, CATHETERS, DEVICES FOR OPHTHALMOLOGY, NEPHROLOGY, APPLICATIONS FOR CONTROLLED DRUG RELEASE, ETC.) AND THE PROBLEMS ASSOCIATED WITH IMPLANTATION (RESPONSE OF THE IMMUNE SYSTEM, INFECTIONS, TECHNIQUES OF STERILIZATION) TOGETHER WITH THEIR POSSIBLE SOLUTIONS, WILL ALSO BE DESCRIBED. THE MAIN SKILLS DEVELOPED BY THE STUDENT WILL BE: - THE ABILITY TO DISCUSS AND ANALYZE THE PROBLEMS RELATING TO THE INTERACTION BETWEEN MATERIALS AND BIOLOGICAL SYSTEMS - RECOGNIZE THE APPLICATION POTENTIALS AND THE CRITICAL POINTS OF A MATERIAL IN THE BIOMEDICAL AREA

MODULE 1 (RIZZO)
BIOMATERIALS: CHEMICAL STRUCTURES AND PHYSICAL PROPERTIES
THE COURSE AIMS TO DESCRIBE THE STRUCTURAL CHARACTERISTICS OF BIOMATERIALS AND THEIR PHYSICAL PROPERTIES.
N DETAIL, THE CRYSTAL STRUCTURES OF METALS, ALLOYS, CERAMIC MATERIALS AND POLYMERIC MATERIALS WILL BE DESCRIBED. THE IMPERFECTIONS PRESENT IN SOLIDS, POINT DEFECTS AND DISLOCATIONS WILL BE DESCRIBED, HIGHLIGHTING HOW THEIR PRESENCE ALTERS THE PROPERTIES OF THE MATERIALS THEMSELVES, FOR EXAMPLE INCREASING THEIR RESISTANCE .
THE MAIN TECHNIQUES OF CHARACTERIZATION OF THE MATERIALS WILL BE BRIEFLY INTRODUCED AND IN PARTICULAR THE TECHNIQUES FOR THE DETERMINATION OF THE CRYSTALLINE STRUCTURES OF SOLIDS AND THE MICROSCOPIC ONES AIMED FOR EXAMPLE AT THE DETERMINATION OF GRAIN SIZES WILL BE BRIEFLY DESCRIBED.
PARTICULAR ATTENTION WILL BE PAID TO DESCRIBING HOW THE TRANSFORMATION OF THE MICROSTRUCTURE MODIFIES THE PROPERTIES OF THE MATERIALS THEMSELVES, SUCH AS THE THERMAL PROPERTIES (THERMAL CAPACITY, THERMAL EXPANSION, THERMAL CONDUCTIVITY) AND OPTICAL PROPERTIES.
THE MAIN SKILLS DEVELOPED BY THE STUDENT WILL BE:
- RECOGNIZE THE CHEMICAL-PHYSICAL AND STRUCTURAL PROPERTIES OF THE DIFFERENT BIOMATERIALS
- CORRELATING THE PROPERTIES OF A BIOMATERIAL WITH POSSIBLE APPLICATIONS IN THE BIOMEDICAL FIELD

MODULE 2 (VENDITTO)
BIOMATERIALS: MEDICAL DEVICES AND THEIR INTERACTION WITH BIOLOGICAL SYSTEMS
THE AIM OF THE COURSE IS TO DESCRIBE THE MOST WIDESPREAD AND USED MATERIALS FOR BIOMEDICAL APPLICATIONS. IN PARTICULAR, THE CHEMICAL AND PHYSICAL PROPERTIES INVOLVED IN THE INTERACTION WITH THE BIOLOGICAL SYSTEMS OF THESE MATERIALS WILL BE DESCRIBED. THE CLASSES OF MATERIALS USED IN MEDICINE (CERAMICS, METALS, POLYMERS, COMPOSITES) IN THEIR MOST WIDESPREAD APPLICATIONS WILL ALSO BE DESCRIBED.
THE MOST IMPORTANT THERAPEUTIC DEVICES (ARTICULATION AND DENTAL PROSTHESES, CARDIOVASCULAR DEVICES, CATHETERS, DEVICES FOR OPHTHALMOLOGY, NEPHROLOGY, APPLICATIONS FOR CONTROLLED DRUG RELEASE, ETC.) AND THE PROBLEMS ASSOCIATED WITH IMPLANTATION (RESPONSE OF THE IMMUNE SYSTEM, INFECTIONS, TECHNIQUES OF STERILIZATION) TOGETHER WITH THEIR POSSIBLE SOLUTIONS, WILL ALSO BE DESCRIBED.
THE MAIN SKILLS DEVELOPED BY THE STUDENT WILL BE:
- THE ABILITY TO DISCUSS AND ANALYZE THE PROBLEMS RELATING TO THE INTERACTION BETWEEN MATERIALS AND BIOLOGICAL SYSTEMS
- RECOGNIZE THE APPLICATION POTENTIALS AND THE CRITICAL POINTS OF A MATERIAL IN THE BIOMEDICAL AREA

	Prerequisites
	NECESSARY KNOWLEDGE OF PHYSICS AND CHEMISTRY, AS WELL AS THOSE OF POLYMER CHEMISTRY

	Contents
	1) FIRST MODULE (BIOMATERIALS: CHEMICAL STRUCTURES AND PHYSICAL PROPERTIES; PROF.SSA P. RIZZO): STRUCTURAL CHARACTERISTICS OF THE MATERIALS AND THEIR PHYSICAL PROPERTIES. CRYSTAL STRUCTURES OF METALS, ALLOYS, CERAMIC MATERIALS, COMPOSITE MATERIALS AND POLYMERIC MATERIALS. IMPERFECTIONS PRESENT IN SOLIDS, PUNCTUAL DEFECTS AND DISLOCATIONS HIGHLIGHTING HOW THEIR PRESENCE ALTERS THE PROPERTIES OF THE MATERIALS ITSELF, INCREASING FOR EXAMPLE THE RESISTANCE. MAIN TECHNIQUES OF CHARACTERIZATION OF MATERIALS AND IN PARTICULAR THE TECHNIQUES FOR THE DETERMINATION OF CRYSTAL STRUCTURES OF SOLIDS AND THE MICROSCOPIC TIMES FOR EXAMPLE TO DETERMINING THE SIZE OF THE GRAINS (TEM, SEM) WILL BE BRIEFLY DESCRIBED. TRANSFORMATION OF MICROSTRUCTURE AND THEREFORE OF THE PROPERTIES OF THE SAME MATERIALS AS FOR EXAMPLE THE THERMAL PROPERTIES (THERMAL CAPACITY, THERMAL EXPANSION, THERMAL CONDUCTIVITY) AND OPTICAL. 2) SECOND MODULE (BIOMATERIALS: MEDICAL DEVICES AND INTERACTION WITH BIOLOGICAL SYSTEMS; PROF. V. VENDITTO) BIOMATERIALS AND BIOCOMPATIBILITY, BIO-INERTIA AND BIO-ACTIVITY, DEFINITIONS. (0.5 CFU) INTRODUCTION TO THE CLASSES OF MATERIALS USED IN MEDICINE (CERAMIC, METALLIC, POLYMERIC, COMPOSITES). (0.5 CFU) THERAPEUTIC DEVICES AND ADDRESSED PROBLEMS (ORTHOPEDICS, DENTISTRY, CARDIOVASCULAR DEVICES, CATHETERS, OPHTHALMOLOGY, NEPHROLOGY, CONTROLLED RELEASE OF DRUGS, ETC.) (0.5 CFU) CERAMIC BIOMATERIALS (PREPARATION TECHNIQUES, PROPERTY-STRUCTURE RELATIONSHIP, ADVANTAGES AND DISADVANTAGES, APPLICATIONS) (0.5 CFU) METALLIC BIOMATERIALS (METALS AND ALLOYS, PROPERTY-STRUCTURE RELATIONSHIP, ADVANTAGES AND DISADVANTAGES, APPLICATIONS). (0.5 CFU) POLYMERIC BIOMATERIALS (DEFINITIONS AND CLASSIFICATIONS, SUMMARY OF SUMMARY, SOLID STATE AND PROPERTY-STRUCTURE RELATIONSHIP, ADVANTAGES AND DISADVANTAGES AND APPLICATIONS FOR POLYMER CLASSES). (1 CFU) COMPOSITE BIOMATERIALS (DEFINITIONS, PREPARATION, PROPERTY-STRUCTURE RELATIONSHIP, ADVANTAGES AND DISADVANTAGES, APPLICATIONS). (1 CFU) PROBLEMS ASSOCIATED WITH THE SYSTEM (INFECTIONS, REJECT ETC.) AND THEIR POSSIBLE SOLUTION (STERILIZATION TECHNIQUES). (0.5 CFU) BIOMATERIALS WITH ANTI-MICROBIAL ACTIVITY. (0.5 CFU) IDROGELI (DEFINITIONS, PREPARATION, PROPERTY-STRUCTURE REPORT, ADVANTAGES AND DISADVANTAGES, APPLICATIONS) (0.5 CFU)

Contents

1) FIRST MODULE (BIOMATERIALS: CHEMICAL STRUCTURES AND PHYSICAL PROPERTIES; PROF.SSA P. RIZZO):
STRUCTURAL CHARACTERISTICS OF THE MATERIALS AND THEIR PHYSICAL PROPERTIES.
CRYSTAL STRUCTURES OF METALS, ALLOYS, CERAMIC MATERIALS, COMPOSITE MATERIALS AND POLYMERIC MATERIALS.
IMPERFECTIONS PRESENT IN SOLIDS, PUNCTUAL DEFECTS AND DISLOCATIONS HIGHLIGHTING HOW THEIR PRESENCE ALTERS THE PROPERTIES OF THE MATERIALS ITSELF, INCREASING FOR EXAMPLE THE RESISTANCE.
MAIN TECHNIQUES OF CHARACTERIZATION OF MATERIALS AND IN PARTICULAR THE TECHNIQUES FOR THE DETERMINATION OF CRYSTAL STRUCTURES OF SOLIDS AND THE MICROSCOPIC TIMES FOR EXAMPLE TO DETERMINING THE SIZE OF THE GRAINS (TEM, SEM) WILL BE BRIEFLY DESCRIBED.
TRANSFORMATION OF MICROSTRUCTURE AND THEREFORE OF THE PROPERTIES OF THE SAME MATERIALS AS FOR EXAMPLE THE THERMAL PROPERTIES (THERMAL CAPACITY, THERMAL EXPANSION, THERMAL CONDUCTIVITY) AND OPTICAL.

2) SECOND MODULE (BIOMATERIALS: MEDICAL DEVICES AND INTERACTION WITH BIOLOGICAL SYSTEMS; PROF. V. VENDITTO)
BIOMATERIALS AND BIOCOMPATIBILITY, BIO-INERTIA AND BIO-ACTIVITY, DEFINITIONS. (0.5 CFU)
INTRODUCTION TO THE CLASSES OF MATERIALS USED IN MEDICINE (CERAMIC, METALLIC, POLYMERIC, COMPOSITES). (0.5 CFU)
THERAPEUTIC DEVICES AND ADDRESSED PROBLEMS (ORTHOPEDICS, DENTISTRY, CARDIOVASCULAR DEVICES, CATHETERS, OPHTHALMOLOGY, NEPHROLOGY, CONTROLLED RELEASE OF DRUGS, ETC.) (0.5 CFU)
CERAMIC BIOMATERIALS (PREPARATION TECHNIQUES, PROPERTY-STRUCTURE RELATIONSHIP, ADVANTAGES AND DISADVANTAGES, APPLICATIONS) (0.5 CFU)
METALLIC BIOMATERIALS (METALS AND ALLOYS, PROPERTY-STRUCTURE RELATIONSHIP, ADVANTAGES AND DISADVANTAGES, APPLICATIONS). (0.5 CFU)
POLYMERIC BIOMATERIALS (DEFINITIONS AND CLASSIFICATIONS, SUMMARY OF SUMMARY, SOLID STATE AND PROPERTY-STRUCTURE RELATIONSHIP, ADVANTAGES AND DISADVANTAGES AND APPLICATIONS FOR POLYMER CLASSES). (1 CFU)
COMPOSITE BIOMATERIALS (DEFINITIONS, PREPARATION, PROPERTY-STRUCTURE RELATIONSHIP, ADVANTAGES AND DISADVANTAGES, APPLICATIONS). (1 CFU)
PROBLEMS ASSOCIATED WITH THE SYSTEM (INFECTIONS, REJECT ETC.) AND THEIR POSSIBLE SOLUTION (STERILIZATION TECHNIQUES). (0.5 CFU)
BIOMATERIALS WITH ANTI-MICROBIAL ACTIVITY. (0.5 CFU)
IDROGELI (DEFINITIONS, PREPARATION, PROPERTY-STRUCTURE REPORT, ADVANTAGES AND DISADVANTAGES, APPLICATIONS) (0.5 CFU)

	Teaching Methods
	THE COURSE IS MADE UP OF FRONTAL LESSONS AND LABORATORY ACTIVITIES. LABORATORY ACTIVITIES PROVIDE THE SYNTHESIS AND CHARACTERIZATION OF BIOMATERIALS. DURING THESE ACTIVITIES THE MAIN INSTRUMENTS USED IN THE FIELD OF BIOMATERIALS WILL BE DESCRIBED AND USED. VISITS TO APPLICATION LABORATORIES IN THE BIOMEDICAL AREA OF MATERIALS ARE ALSO PROVIDED.

	Verification of learning
	THE EXAM IS AIMED TO ENSURE THAT THE STUDENT ACHIEVES THE TRAINING OBJECTIVES PROVIDED BY THE TEACHING. THE ACHIEVEMENT OF THE OBJECTIVES OF THE TEACHING IS VERIFIED BY PASSING AN EXAM WITH A THIRTYTH EVALUATION. THE EXAM INCLUDES TWO ORAL TESTS, ONE AT THE END OF EACH MODULE. EACH TEST IS ASSESSED IN THIRTY AND IS INTENDED TO BE PASSED WITH A MINIMUM VOTE OF 18/30. THE FINAL VOTE IS GIVEN BY THE AVERAGE OF THE VOTES REPORTED IN EACH ORAL TEST. AS AN ALTERNATIVE, THE STUDENT WILL BE ABLE TO TAKE A SINGLE ORAL EXAM ON BOTH THE TOPICS COVERED IN THE INDIVIDUAL MODULES BOTH INDIVIDUAL ORAL TESTS WILL BE OF THE ORIENTATIVE DURATION OF 45 MINUTES, DURING WHICH THE STUDENT WILL HAVE TO ANSWER A SERIES OF QUESTIONS THAT COVER ALL THE TOPICS COVERED IN THE RELATED FORM

Verification of learning

THE EXAM IS AIMED TO ENSURE THAT THE STUDENT ACHIEVES THE TRAINING OBJECTIVES PROVIDED BY THE TEACHING.
THE ACHIEVEMENT OF THE OBJECTIVES OF THE TEACHING IS VERIFIED BY PASSING AN EXAM WITH A THIRTYTH EVALUATION. THE EXAM INCLUDES TWO ORAL TESTS, ONE AT THE END OF EACH MODULE. EACH TEST IS ASSESSED IN THIRTY AND IS INTENDED TO BE PASSED WITH A MINIMUM VOTE OF 18/30. THE FINAL VOTE IS GIVEN BY THE AVERAGE OF THE VOTES REPORTED IN EACH ORAL TEST.
AS AN ALTERNATIVE, THE STUDENT WILL BE ABLE TO TAKE A SINGLE ORAL EXAM ON BOTH THE TOPICS COVERED IN THE INDIVIDUAL MODULES
BOTH INDIVIDUAL ORAL TESTS WILL BE OF THE ORIENTATIVE DURATION OF 45 MINUTES, DURING WHICH
THE STUDENT WILL HAVE TO ANSWER A SERIES OF QUESTIONS THAT COVER ALL THE TOPICS COVERED IN THE RELATED FORM

	Texts
	MODULE I: MATERIALS SCIENCE AND ENGINEERING III ED. WILLIAM D. CALLISTER, DAVID G.RETHWISCH EDISES SRL EDITION 2012 NAPLES MODULE II: BIOMATERIALS SCIENCE (THIRD EDITION) AN INTRODUCTION TO MATERIALS IN MEDICINE, EDITED BY: BUDDY D. RATNER, ALLAN S. HOFFMAN, FREDERICK J. SCHOEN AND JACK E. LEMONS, ISBN: 978-0-12-374626-9 COURSE SLIDES AND ADDITIONAL EDUCATIONAL MATERIAL WILL BE MADE AVAILABLE BY THE TEACHER IN PAPER OR DIGITAL FORM

Texts

MODULE I: MATERIALS SCIENCE AND ENGINEERING III ED. WILLIAM D. CALLISTER, DAVID G.RETHWISCH EDISES SRL EDITION 2012 NAPLES
MODULE II: BIOMATERIALS SCIENCE (THIRD EDITION) AN INTRODUCTION TO MATERIALS IN MEDICINE, EDITED BY: BUDDY D. RATNER, ALLAN S. HOFFMAN, FREDERICK J. SCHOEN AND JACK E. LEMONS, ISBN: 978-0-12-374626-9
COURSE SLIDES AND ADDITIONAL EDUCATIONAL MATERIAL WILL BE MADE AVAILABLE BY THE TEACHER IN PAPER OR DIGITAL FORM

	More Information
	ALWAYS CONTACT THE TEACHER BEFORE THE EXAM

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Vincenzo VENDITTO | BIOMATERIALS