Ornella MOLTEDO | BIOCHEMISTRY
Ornella MOLTEDO BIOCHEMISTRY
cod. 0760400011
BIOCHEMISTRY
| 0760400011 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF7 | |
| PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY | |
| 2024/2025 |
| OBBLIGATORIO | |
| YEAR OF COURSE 2 | |
| YEAR OF DIDACTIC SYSTEM 2023 | |
| SPRING SEMESTER |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| BIO/10 | 9 | 72 | LESSONS |
| Objectives | |
|---|---|
| THE TRAINING OBJECTIVE OF THE COURSE IS: PROVIDE KNOWLEDGE: I) ON THE STRUCTURE AND FUNCTION OF THE MAIN BIOMOLECULES; II) ON THE MAIN PATHWAYS OF ENERGY METABOLISM AND ITS REGULATION, AND TO PROVIDE THE TOOLS FOR UNDERSTANDING THE GENERAL STRATEGIES THAT DRIVE THE VITAL PROCESSES. AT THE END OF THE COURSE THE STUDENT WILL KNOW: I) THE MECHANISMS OF REGULATION OF THE MAIN ENZYMATIC REACTIONS IN RELATION TO CELLULAR METABOLISM, II) THE PROCESSES OF PRODUCTION AND USE OF ENERGY, AND III) THE STRATEGIES AND BIOLOGICAL PURPOSES THAT MAKE INTERDEPENDENT STAGES OF METABOLISM. THE STUDENT APPLYING THE ACQUIRED SKILLS, WILL BE ABLE TO OUTLINE THE OVERALL PICTURE OF THE METABOLISM AT THE MOLECULAR AND CELLULAR LEVEL, AND APPLY IT TO THE STUDY OF RELATIONS BETWEEN DIFFERENT METABOLIC PATHWAYS. AT THE END OF THE COURSE THE STUDENT WILL HAVE ACQUIRED CRITICAL SKILLS THAT ALLOW HIM TO CONTEXTUALIZE THE BIOCHEMICAL KNOWLEDGE ACQUIRED IN THE EXPERIMENTAL LABORATORY PRACTICE. THE STUDENT WILL BE ABLE TO SHARE, THROUGH COMMUNICATION, THE ACQUIRED KNOWLEDGE, THUS DEMONSTRATING FULL UNDERSTANDING AND MASTERY. THE STUDENT WILL BE ABLE TO ACQUIRE A LEARNING METHOD THAT ALLOWS HIM TO PROCEED IN AN AUTONOMOUS AND CRITICAL WAY DURING HIS EDUCATION TRAINING. |
| Prerequisites | |
|---|---|
| PREREQUISITES THE ACQUISITION OF BASIC OBJECTIVES RELATING TO THE FOLLOWING DISCIPLINES IS REQUIRED: GENERAL BIOLOGY, PHYSIOLOGY, HUMAN ANATOMY, GENERAL AND INORGANIC CHEMISTRY, ORGANIC CHEMISTRY I |
| Contents | |
|---|---|
| COURSE CONTENTS CHEMICAL BONDS AND FUNCTIONAL GROUPS (2 HR) ROLE OF WATER IN BIOLOGICAL PROCESSES (1 HR) AMINO ACIDS STRUCTURE AND PROPERTIES (2 HR) PROTEINS PRIMARY AND SECONDARY STRUCTURE (2 HR) SPATIAL ORGANIZATION OF PROTEINS AND THEIR CLASSIFICATION (2 HR) OXYGEN TRANSPORT PROTEINS (2 HR) HETEROTOPIC ALLOSTERIC REGULATORS OF HEMOGLOBIN (2 HR) ENZYMES – CLASSIFICATION AND GENERAL ASPECTS OF ENZYMATIC CATALYSIS (4 HR) KINETIC PARAMETERS (KM AND VMAX) DEFINITION AND ENZYMATIC REGULATION (4 HR) TRANSMISSION OF INFORMATION: CLASSIFICATION AND PROPERTIES OF NUCLEIC ACIDS (4 HR) GENERAL ASPECTS AND BASES OF ENERGY METABOLISM BIOENERGETICS: ATP: SUBSTRATE LEVEL PHOSPHORYLATIONS (4 HR) OXIDATIVE PHOSPHORYLATION (2 HR) CARBOHYDRATES: STRUCTURE, CLASSIFICATION, PROPERTIES (2 HR) GLYCOLYSIS: REACTIONS AND ENERGY BALANCE (4 HR) FATE OF PYRUVATE (2 HR) GLYCOGEN METABOLISM (3 HR) GLUCONEOGENESIS (2 HR) ALLOSTERIC AND HORMONAL REGULATION OF GLUCOSE METABOLISM (1 HR) PENTOSE-PHOSPHATE CYCLE AND REGULATION (2 HR) LIPID STRUCTURE, CLASSIFICATION, PROPERTIES (2 HR) ABSORPTION AND TRANSPORT HYDROLYSIS OF TRIGLYCERIDES (2 HR) FATTY ACID OXIDATION (2 HR) KETONE BODIES: PHYSIO-PATHOLOGICAL SIGNIFICANCE (1 HR) BIOSYNTHESIS OF FATTY ACIDS AND TRIGLYCERIDES. CHOLESTEROL (3 HR) HORMONAL AND NON-HORMONAL REGULATION OF LIPID METABOLISM (1 HR) THE CITRIC ACID CYCLES. REACTIONS AND AMPHIBOLIC NATURE OF THE CYCLE (4 HR) METABOLISM OF NITROGENOUS COMPOUNDS: DIGESTION OF EXOGENOUS PROTEINS AND DEGRADATION OF ENDOGENOUS PROTEINS (3 HR) AMINO ACID METABOLISM AND UREA CYCLE (3 HR) BIOSYNTHESIS AND CATABOLISM OF PURINE AND PYRIMIDINE BASES (4 HR) ALL TOPICS WILL BE ADDRESSED BY FOCUSING ON THE STRATEGIES UNDERLYING VITAL PROCESSES, AIMED AT OPTIMIZING THE ACHIEVEMENT OF TWO OBJECTIVES: CORRECT DIRECTION OF A METABOLIC FLOW IN RESPONSE TO SPECIFIC NEEDS, AND REDUCTION OF ENERGY COSTS. |
| Teaching Methods | |
|---|---|
| TEACHING METHODS THE TEACHING OF GENERAL BIOCHEMISTRY INCLUDES 9 CREDITS (72 HOURS) AND WILL TAKE PLACE THROUGH LECTURES, INTERACTIVE TEACHING, AND SEMINAR ACTIVITIES. AS PER THE TEACHING REGULATIONS, ATTENDANCE AT THE GENERAL BIOCHEMISTRY COURSE MUST BE CONSIDERED COMPULSORY, THE PROCEDURES FOR VERIFYING ATTENDANCE WILL BE COMMUNICATED TO THE STUDENTS BY THE TEACHER AT THE BEGINNING OF THE COURSE. |
| Verification of learning | |
|---|---|
| VERIFICATION OF LEARNING ONGOING SELF-EVALUATION TESTS DURING THE COURSE USING BOTH MULTIPLE CHOICE AND OPEN-ENDED QUESTIONS, LASTING 45 MINUTES, AIMED AT EVALUATING UNDERSTANDING AND KNOWLEDGE OF THE TOPICS COVERED. THE FINAL TEST INCLUDES AN IN-DEPTH ORAL INTERVIEW LASTING A MINIMUM OF 30 MINUTES, AIMED AT EVALUATING THE STUDENT'S ABILITIES IN COORDINATING AND CONTEXTUALIZING THE INFORMATION ACQUIRED, AS WELL AS VERIFYING THEIR ABILITY TO UNDERSTAND AND PRESENT IT USING APPROPRIATE TERMINOLOGY. THE FINAL GRADE, EXPRESSED IN THIRTIETHS, FROM 18/30 TO 30/30 CUM LAUDE, CONSIDERS THE KNOWLEDGE ACQUIRED RELATING TO THE STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF THE MAIN CLASSES OF BIOMOLECULES, AND KNOWLEDGE REGARDING CELLULAR METABOLISM AND ITS REGULATION. FOR THE PURPOSES OF AWARDING HONORS, THE USE OF APPROPRIATE SCIENTIFIC LANGUAGE AND THE INDEPENDENCE OF JUDGMENT DEMONSTRATED WILL BE CONSIDERED. |
| Texts | |
|---|---|
| TEXTS THERE ARE NUMEROUS TEXTS CAPABLE OF PROVIDING THE ELEMENTS NECESSARY FOR THE STUDY OF THE TOPICS DESCRIBED IN THE EXAM PROGRAM IN EQUIVALENT QUANTITIES. BELOW IS A LIST OF SOME OF THE MOST WIDESPREAD AND USED TEXTS: 1) LEHNINGER, NELSON & COX, I PRINCIPI DI BIOCHIMICA DI LEHNINGER, ED. ZANICHELLI; 2) TYMOCZKO, BERG, STRYER, BIOCHIMICA, ED. ZANICHELLI; 4) VOET & VOET, BIOCHIMICA, ED. ZANICHELLI |
| More Information | |
|---|---|
| OTHER INFORMATION TEACHING LANGUAGE: ITALIAN FREQUENCY METHOD: MANDATORY LOCATION: DEPARTMENT OF PHARMACY FOR FURTHER INFORMATION, CONTACT PROF. ORNELLA MOLTEDO AT THE FOLLOWING ADDRESS:MOLTEDO@UNISA.IT |
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