PHYTOCHEMISTRY AND PHARMACOGNOSY

Sonia PIACENTE PHYTOCHEMISTRY AND PHARMACOGNOSY

0760400019
DIPARTIMENTO DI FARMACIA
EQF7
PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY
2024/2025

OBBLIGATORIO
YEAR OF COURSE 3
YEAR OF DIDACTIC SYSTEM 2023
AUTUMN SEMESTER
CFUHOURSACTIVITY
864LESSONS
Objectives
THE COURSE IS AIMED AT PROVIDING KNOWLEDGE ON THE MAIN PATHWAYS OF PLANT SPECIALIZED METABOLISM AND ON HERBAL DRUGS.
KNOWLEDGE AND UNDERSTANDING
-MAIN PATHWAYS OF PLANT SPECIALIZED METABOLISM;
-CHEMICAL FEATURES AND BIOSYNTHETIC ASPECTS OF BIOACTIVE PLANT METABOLITES;
-CLASSIFICATION, PRODUCTION AND VARIABILITY OF PLANTS AND RELATED HERBAL DRUGS OF PHARMACEUTICAL AND HEALTH INTEREST;
-BIOLOGICAL ACTIVITY OF HERBAL DRUGS AND RELATED ACTIVE PRINCIPLES.
ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING
-RECOGNIZE THE PHYTOCHEMICAL AND PHARMACOGNOSTIC FEATURES OF HERBAL DRUGS;
-ADDRESS AND SOLVE PROBLEMS RELATED TO THE USE OF PLANTS, HERBAL DRUGS AND RELATED PRODUCTS IN PHARMACEUTICAL AND HEALTH FIELD.

Prerequisites
STUDENTS ARE REQUIRED TO HAVE PASSED THE EXAMS OF THE FIRST YEAR AND ORGANIC CHEMISTRY I
Contents
PLANT NOMENCLATURE AND TAXONOMY. PLANTS AND THEIR MORPHOLOGY. ORGANIZED AND NOT ORGANIZED HERBAL DRUGS. CONSERVATION AND EXTRACTION METHODS OF HERBAL DRUGS. MAIN FEATURES OF HERBAL DRUGS AND PREPARATIONS (2 H).
FOR EACH HERBAL DRUG: BOTANICAL SOURCE, MACROSCOPIC AND MICROSCOPIC FEATURES, QUALI-QUANTITATIVE CHEMICAL PROFILE, BIOACTIVE CONSTITUENTS, BIOLOGICAL ACTIVITY. THERAPEUTIC USES OF HERBAL DRUGS INCLUDED IN PHARMACOPOEIA.
PRIMARY AND SECONDARY PLANT METABOLISM (2 H).
PLANT METABOLIC PATHWAYS: STRUCTURES, PROPERTIES AND CLASSIFICATION OF SECONDARY METABOLITES (3 H).
EXTRACTION AND ISOLATION METHODS OF SECONDARY METABOLITES (2 H).
CARBOHYDRATES IN PLANTS (1H) AND HERBAL DRUGS EMPLOYED FOR THEIR CONTENT IN CARBOHYDRATES (2 H).
HERBAL DRUGS BASED ON GUMS, RESINS, GUM-RESINS AND BALSAMS (1 H)
LIPIDS (1 H) AND HERBAL DRUGS EMPLOYED FOR THEIR CONTENT IN LIPIDS (2 H).
SHIKIMIC ACID PATHWAY: CHEMICAL FEATURES OF THE DIFFERENT CLASSES OF PHENOLIC COMPOUNDS (6 H). HERBAL DRUGS CONTAINING PHENOLICS, TANNINS, PHENYLPROPANOIDS, COUMARINS, LIGNANS (6 H).
ACETATE PATHWAY: ANTRAQUINONES AND RELATIVE HERBAL DRUGS (2 H).
COMPOUNDS WITH MIXED BIOGENESIS: FLAVONOIDS AND RESVERATROL AND THEIR BIOLOGICAL ACTIVITIES (2 H).
MEVALONATE PATHWAY. TERPENE COMPOUNDS: MONOTERPENS, SESQUITERPENS, DITERPENS. HERBAL DRUGS EMPLOYED FOR THEIR CONTENT IN TERPENOIDS (ESSENTIAL OILS, SESQUITERPENES AND DITERPENES) (6 H)
STEROIDS, TRITERPENE SAPONINS, STEROIDAL SAPONINS, CARDIAC GLYCOSIDES AND RELATED HERBAL DRUGS (8 H).
ALKALOIDS AND THEIR BIOLOGICAL AND ECOLOGICAL ROLE IN PLANTS. CHEMICAL FEATURES AND CLASSIFICATION (2 H).
ALKALOIDS DERIVED FROM ORNITHINE (2 H). ALKALOIDS DERIVED FROM LYSINE AND RELATED HERBAL DRUGS (2H). ALKALOIDS DERIVED FROM PHENYLALANINE AND TYROSINE AND RELATED HERBAL DRUGS (5 H). ALKALOIDS DERIVED FROM TRYPTOPHAN AND RELATED HERBAL DRUGS (5H). ALKALOIDS DERIVED FROM A MIXED PATHWAY AND RELATED HERBAL DRUGS (2 H).
Teaching Methods
LECTURES, SEMINARS, TUTORIALS
Verification of learning
THE EXAM CONSISTS OF A WRITTEN AND ORAL TEST, TO BE SUSTAINED IN THE SAME EXAM SESSION. THE RATING IS X/30. TO PASS THE WRITTEN TEST WITH A SCORE OF 18/30 IS MANDATORY TO ACCESS TO THE ORAL TEST AND REACH THE FINAL GRADE. THE WRITTEN TEST TAKES TWO HOURS AND CONSISTS OF OPEN QUESTIONS ON THE MAIN LEARNING OUTCOMES. EACH QUESTION IS ADDRESSED TO VERIFY KNOWLEDGES OF BOTH PHARMACOGNOSY AND PHYTOCHEMISTRY.
THE STUDENT WILL BE ASKED TO DISCUSS THE MAIN TOPICS OF THE COURSE, TRYING TO DEMONSTRATE CRITICAL THOUGHT AND AWARENESS OF THE SUBJECTS OF THE FIELD OF STUDY.
Texts
DEWICK PAUL M., CHIMICA, BIOSINTESI E BIOATTIVITÀ DELLE SOSTANZE NATURALI 2/ED.- EDIZIONE ITALIANA A CURA DI ERNESTO FATTORUSSO [DEWICK - PICCIN EDITORE]
MANN J. CHEMICAL ASPECTS OF BIOSYNTHESIS, CHEMISTRY PRIMERS, OXFORD.
MAZZANTI G., DELL'AGLI M, IZZO A.A.
FARMACOGNOSIA E FITOTERAPIA BASI FARMACOLOGICHE E ASPETTI APPLICATIVI, PICCIN, PADOVA.
G. SAMUELSSON FARMACOGNOSIA - FARMACI DI ORIGINE NATURALE. SECONDA EDIZIONE ITALIANA A CURA DI: F. CAPASSO, R. DE PASQUALE, I. MORELLI, CASA EDITRICE EMSI, ROMA.
F. CAPASSO, R. DE PASQUALE, G. GRANDOLINI, N. MASCOLO.
FARMACOGNOSIA: FARMACI NATURALI, LORO PREPARAZIONI ED IMPIEGO TERAPEUTICO, CASA EDITRICE: SPRINGER-VERLAG
More Information
SONIA PIACENTE
HTTP://WWW.UNISA.IT/DOCENTI/SONIAPIACENTE/INDEX
Lessons Timetable

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