Giovanna DELLA PORTA | C.I. CHEMISTRY AND PROPAEDEUTIC BIOCHEMISTRY

cod. 1060200003

C.I. CHEMISTRY AND PROPAEDEUTIC BIOCHEMISTRY

	1060200003
	DEPARTMENT OF MEDICINE, SURGERY AND DENTISTRY "SALERNITANA MEDICAL SCHOOL"
	EQF7
	DENTISTRY
	2023/2024

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 1
	YEAR OF DIDACTIC SYSTEM 2023
	AUTUMN SEMESTER

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	C.I. CHIMICA E PROPEDEUTICA BIOCHIMICA - MOD. CHIMICA
	BIO/10	6	66	LESSONS	BASIC COMPULSORY SUBJECTS
2	C.I. CHIMICA E PROPEDEUTICA BIOCHIMICA - FARMACEUTICO TECNOLOGICO APPLICATIVO
	CHIM/09	2	22	LESSONS	SUPPLEMENTARY COMPULSORY SUBJECTS

PROFESSORS

	LIBERATO MARZULLO1 T Curriculum
	GIOVANNA DELLA PORTA2 Curriculum

	Objectives
	STUDENTS WILL DEVELOP THE FOLLOWING SKILLS: - TO ACQUIRE THE NECESSARY BASIC KNOWLEDGE OF CHEMISTRY FOR ANALYSING MOLECULES AND MECHANISMS OF BIOMEDICAL INTEREST; - TO KNOW STRUCTURE AND FUNCTION OF THE MAIN MOLECULES OF BIOMEDICAL INTEREST; - TO BE ABLE TO UNDERSTAND AT THE MOLECULAR LEVEL THE PROCESSES DESCRIBED BY BIOMEDICAL SCIENCES TEACHED IN THE FOLLOWING YEARS OF STUDIES - TO KNOW THE CHEMISTRY OF THE MAIN POLYMERIZATION REACTIONS AND THE STRUCTURAL FEATURES OF SOME NATURAL AND SYNTHETIC POLYMERS - TO APPLY THE KNOWLEDGE ACQUIRED DURING THE PREPARATORY LEARNING PHASE IN DETERMINING THE CHEMICAL PROPERTIES THAT REGULATE THE ACTION OF A DRUG

STUDENTS WILL DEVELOP THE FOLLOWING SKILLS:
- TO ACQUIRE THE NECESSARY BASIC KNOWLEDGE OF CHEMISTRY FOR ANALYSING MOLECULES AND MECHANISMS OF BIOMEDICAL INTEREST;
- TO KNOW STRUCTURE AND FUNCTION OF THE MAIN MOLECULES OF BIOMEDICAL INTEREST;
- TO BE ABLE TO UNDERSTAND AT THE MOLECULAR LEVEL THE PROCESSES DESCRIBED BY BIOMEDICAL SCIENCES TEACHED IN THE FOLLOWING YEARS OF STUDIES
- TO KNOW THE CHEMISTRY OF THE MAIN POLYMERIZATION REACTIONS AND THE STRUCTURAL FEATURES OF SOME NATURAL AND SYNTHETIC POLYMERS
- TO APPLY THE KNOWLEDGE ACQUIRED DURING THE PREPARATORY LEARNING PHASE IN DETERMINING THE CHEMICAL PROPERTIES THAT REGULATE THE ACTION OF A DRUG

	Prerequisites
	ACCORDING TO SECTION 11 OF THE PUBLISHED DIDACTIC GUIDELINES

	Contents
	THE COURSE (8 CFU) CONSISTS OF 2 MODULES: CHEMISTRY AND BIOCHEMISTRY (6 CFU) AND MODULE PHARMACEUTICAL AND TECHNOLOGICAL APPLICATION (2 CFU). IN THE FOLLOWING THE CONTENTS OF EACH MODULE ARE REPORTED. MODULE: CHEMISTRY AND BIOCHEMISTRY (BIO10) - 6 CFU, 66 HOURS ATOMS AND MOLECULES: STRUCTURE AND PROPERTIES. ATOMIC MODELS. PERIODIC TABLE OF ELEMENTS. NOTES OF SPECTROSCOPY. ELECTRONEGATIVITY. CHEMICAL BONDS. MOLECULAR GEOMETRY AND POLARITY OF MOLECULES. INTERMOLECULAR BONDS. RADIOISOTOPES. RADIOACTIVE DECAYS. RADIOCHEMISTRY AND BIOMEDICAL APPLICATIONS. CHEMICAL REACTIONS: STECHIOMETRY AND ENERGY. STATE OF OXIDATION. RED-OX REACTIONS. THE MOLE. THE ATOMIC AND MOLECULAR WEIGHT. STATES OF MATTER AND PHASE CHANGES. VAPOR PRESSURE; EQ. CLAUSIUS-CLAPEYRON; PHASE DIAGRAMS. THE LAWS OF GAS: IDEAL AND REAL. THERMODYNAMIC FUNCTIONS AND CHEMICAL TRANSFORMATIONS. CHEMICAL KINETICS: ACTIVATION ENERGY, RATE AND RATE CONSTANT, REACTION ORDER AND MOLECULARITY. CATALYSIS. ENZYMES. CHEMICAL EQUILIBRIUM. LAW OF MASS ACTION AND EQUILIBRIUM CONSTANT (KC AND KP). PRINCIPLE OF MOBILE EQUILIBRIUM; EFFECTS OF PERTURBATIONS OF CHEMICAL EQUILIBRIUM. SOLUTIONS: SOLID-LIQUID, LIQUID-LIQUID, GAS-LIQUID. HENRY’S LAW. SOLUBILITY AND UNITS OF CONCENTRATION. COLLIGATIVE PROPERTIES. OSMOSIS, OSMOTIC PRESSURE AND PH. VAPOR PRESSURE. RAOULT'S LAW. DISTILLATION. ACIDS, BASES AND SALTS. ACID-BASE EQUILIBRIUM IN WATER SOLUTIONS. WATER DISSOCIATION. DISSOCIATION CONSTANTS. PH. TITRATIONS AND INDICATORS. BUFFER SOLUTIONS. ELECTROCHEMISTRY: VOLTAIC CELLS; ELECTROCHEMICAL POTENTIALS. ELECTROCHEMISTRY AND THERMODYNAMICS. ELECTROLYSIS MOLECULES OF BIOLOGICAL INTEREST. CARBON AND FUNCTIONAL GROUPS. HYDROCARBONS: NOMENCLATURE, PROPERTIES AND REACTIVITY (N.P.R.) OF ALKANES, ALKENES, ALKYNES. CYCLIC COMPOUNDS. ISOMERIES AND CONFORMATIONAL ANALYSIS. STEREOCHEMISTRY BENZENE AND AROMATICITY. AROMATIC COMPOUNDS: N.P.R. HETEROCYCLIC COMPOUNDS: N.P.R. ALCOHOLS, ETHERS AND SULFURATED ANALOGUES: N.P.R. ALKYL HALIDES AND AMINES: N.P.R. ALDEHYDES AND KETONES: N.P.R. HEMIACETALS AND ACETALS. HEMIKETALS AND KETALS. CARBOXYLIC ACIDS AND DERIVATIVES: (N.P.R.). ACYL HALIDES, ESTERS, THIOESTERS, AMIDES, ANHYDRIDES. CARBOHYDRATES: (N.P.R.). MONOSACCHARIDES, OLIGOSACCHARIDES, POLYSACCHARIDES. FISHER AND HAWORTH PROJECTIONS. FISHER CONVENTION (D, L) AND ABSOLUTE CONFIGURATION (R, S). GLYCOSIDES. AMINO SUGARS. REDUCING AND NON-REDUCING SUGARS. MUTAROTATION. LIPIDS: GENERALITY AND CLASSIFICATION. FATTY ACIDS. TRIACYLYCEROLS. PHOSPHOLIPIDS. STEROIDS: CHOLESTEROL, BILE ACIDS, STEROID HORMONES. AMINO ACIDS AND PROTEINS: STRUCTURE AND PROPERTIES. PEPTIDE BOND. OLIGO- AND POLYPETIDES. NUCLEOSIDES AND NUCLEOTIDES. NUCLEIC ACIDS. MODULE: PHARMACEUTICAL TECHNOLOGICAL APPLICATION (CHIM09) - 2 CFU, 22 HOURS POLYMERS, HOMOPOLYMERS AND COPOLYMERS. THREE-DIMENSIONAL AND SUPRA-MOLECULAR STRUCTURE. NATURAL AND SYNTHETIC POLYMERS. BIODEGRADABILITY AND / OR BIOCOMPATIBILITY. POLYMERS AND REACTIONS OF FUNCTIONAL GROUPS. POLYMERIZATION MECHANISMS: CONDENSATION (ESTERS AND AMIDE BOND); RADICAL ADDITION (POLYETHYLENE, POLYPROPYLENE, POLI-METHACRYLATES). CHEMICAL RADICAL INITIATION AND BY UV LIGHT. CONFORMATIONAL AND CONFIGURATIONAL ISOMERS. TACTICITY. EXAMPLES OF NATURAL BIO-POLYMERS: NUCLEIC ACIDS (DNA AND RNA) AND PHARMACEUTICAL APPLICATIONS (CDNA, MIRNA, SIRNA). POLYSACCHARIDES (STARCH, CELLULOSE, ALGINATES, CHITOSANS), TERTIARY AND QUATERNARY PROTEINS, COLLAGEN, FIBRIN. SYNTHETIC BIODEGRADABLE POLYMERS: POLY-GLYCOLIC (PGA), POLYLACTIC (PLA), POLYLACTIC-CO-GLYCOLIC (PLGA), POLYCAPROLACTONE (PCL). AMORPHOUS, SEMI-CRYSTALLINE AND CRYSTALLINE POLYMERS. MOLECULAR WEIGHT DISTRIBUTION. MECHANICAL PROPERTIES OF POLYMERS, DEFINITION OF ELASTIC MODULE AND STRESS DEFORMATION CURVES. CHANGE IN PHYSICAL STATE AS A FUNCTION OF THE TEMPERATURE; DEFINITION OF GLASS TRANSITION (TG) AND SOFTENING TEMPERATURE (TR).

Contents

THE COURSE (8 CFU) CONSISTS OF 2 MODULES: CHEMISTRY AND BIOCHEMISTRY (6 CFU) AND MODULE PHARMACEUTICAL AND TECHNOLOGICAL APPLICATION (2 CFU).
IN THE FOLLOWING THE CONTENTS OF EACH MODULE ARE REPORTED.

MODULE: CHEMISTRY AND BIOCHEMISTRY (BIO10) - 6 CFU, 66 HOURS
ATOMS AND MOLECULES: STRUCTURE AND PROPERTIES. ATOMIC MODELS. PERIODIC TABLE OF ELEMENTS. NOTES OF SPECTROSCOPY. ELECTRONEGATIVITY. CHEMICAL BONDS. MOLECULAR GEOMETRY AND POLARITY OF MOLECULES. INTERMOLECULAR BONDS. RADIOISOTOPES. RADIOACTIVE DECAYS. RADIOCHEMISTRY AND BIOMEDICAL APPLICATIONS.
CHEMICAL REACTIONS: STECHIOMETRY AND ENERGY. STATE OF OXIDATION. RED-OX REACTIONS. THE MOLE. THE ATOMIC AND MOLECULAR WEIGHT.
STATES OF MATTER AND PHASE CHANGES. VAPOR PRESSURE; EQ. CLAUSIUS-CLAPEYRON; PHASE DIAGRAMS. THE LAWS OF GAS: IDEAL AND REAL.
THERMODYNAMIC FUNCTIONS AND CHEMICAL TRANSFORMATIONS. CHEMICAL KINETICS: ACTIVATION ENERGY, RATE AND RATE CONSTANT, REACTION ORDER AND MOLECULARITY. CATALYSIS. ENZYMES.
CHEMICAL EQUILIBRIUM. LAW OF MASS ACTION AND EQUILIBRIUM CONSTANT (KC AND KP). PRINCIPLE OF MOBILE EQUILIBRIUM; EFFECTS OF PERTURBATIONS OF CHEMICAL EQUILIBRIUM.
SOLUTIONS: SOLID-LIQUID, LIQUID-LIQUID, GAS-LIQUID. HENRY’S LAW. SOLUBILITY AND UNITS OF CONCENTRATION. COLLIGATIVE PROPERTIES. OSMOSIS, OSMOTIC PRESSURE AND PH. VAPOR PRESSURE. RAOULT'S LAW. DISTILLATION.
ACIDS, BASES AND SALTS. ACID-BASE EQUILIBRIUM IN WATER SOLUTIONS. WATER DISSOCIATION. DISSOCIATION CONSTANTS. PH. TITRATIONS AND INDICATORS. BUFFER SOLUTIONS. ELECTROCHEMISTRY: VOLTAIC CELLS; ELECTROCHEMICAL POTENTIALS. ELECTROCHEMISTRY AND THERMODYNAMICS. ELECTROLYSIS
MOLECULES OF BIOLOGICAL INTEREST. CARBON AND FUNCTIONAL GROUPS.
HYDROCARBONS: NOMENCLATURE, PROPERTIES AND REACTIVITY (N.P.R.) OF ALKANES, ALKENES, ALKYNES. CYCLIC COMPOUNDS. ISOMERIES AND CONFORMATIONAL ANALYSIS. STEREOCHEMISTRY
BENZENE AND AROMATICITY. AROMATIC COMPOUNDS: N.P.R. HETEROCYCLIC COMPOUNDS: N.P.R. ALCOHOLS, ETHERS AND SULFURATED ANALOGUES: N.P.R. ALKYL HALIDES AND AMINES: N.P.R. ALDEHYDES AND KETONES: N.P.R. HEMIACETALS AND ACETALS. HEMIKETALS AND KETALS.
CARBOXYLIC ACIDS AND DERIVATIVES: (N.P.R.). ACYL HALIDES, ESTERS, THIOESTERS, AMIDES, ANHYDRIDES. CARBOHYDRATES: (N.P.R.). MONOSACCHARIDES, OLIGOSACCHARIDES, POLYSACCHARIDES. FISHER AND HAWORTH PROJECTIONS. FISHER CONVENTION (D, L) AND ABSOLUTE CONFIGURATION (R, S). GLYCOSIDES. AMINO SUGARS. REDUCING AND NON-REDUCING SUGARS. MUTAROTATION. LIPIDS: GENERALITY AND CLASSIFICATION. FATTY ACIDS. TRIACYLYCEROLS. PHOSPHOLIPIDS. STEROIDS: CHOLESTEROL, BILE ACIDS, STEROID HORMONES.
AMINO ACIDS AND PROTEINS: STRUCTURE AND PROPERTIES. PEPTIDE BOND. OLIGO- AND POLYPETIDES.
NUCLEOSIDES AND NUCLEOTIDES. NUCLEIC ACIDS.

MODULE: PHARMACEUTICAL TECHNOLOGICAL APPLICATION (CHIM09) - 2 CFU, 22 HOURS
POLYMERS, HOMOPOLYMERS AND COPOLYMERS. THREE-DIMENSIONAL AND SUPRA-MOLECULAR STRUCTURE. NATURAL AND SYNTHETIC POLYMERS. BIODEGRADABILITY AND / OR BIOCOMPATIBILITY.
POLYMERS AND REACTIONS OF FUNCTIONAL GROUPS. POLYMERIZATION MECHANISMS: CONDENSATION (ESTERS AND AMIDE BOND); RADICAL ADDITION (POLYETHYLENE, POLYPROPYLENE, POLI-METHACRYLATES). CHEMICAL RADICAL INITIATION AND BY UV LIGHT. CONFORMATIONAL AND CONFIGURATIONAL ISOMERS. TACTICITY.
EXAMPLES OF NATURAL BIO-POLYMERS: NUCLEIC ACIDS (DNA AND RNA) AND PHARMACEUTICAL APPLICATIONS (CDNA, MIRNA, SIRNA). POLYSACCHARIDES (STARCH, CELLULOSE, ALGINATES, CHITOSANS), TERTIARY AND QUATERNARY PROTEINS, COLLAGEN, FIBRIN.
SYNTHETIC BIODEGRADABLE POLYMERS: POLY-GLYCOLIC (PGA), POLYLACTIC (PLA), POLYLACTIC-CO-GLYCOLIC (PLGA), POLYCAPROLACTONE (PCL).
AMORPHOUS, SEMI-CRYSTALLINE AND CRYSTALLINE POLYMERS. MOLECULAR WEIGHT DISTRIBUTION. MECHANICAL PROPERTIES OF POLYMERS, DEFINITION OF ELASTIC MODULE AND STRESS DEFORMATION CURVES. CHANGE IN PHYSICAL STATE AS A FUNCTION OF THE TEMPERATURE; DEFINITION OF GLASS TRANSITION (TG) AND SOFTENING TEMPERATURE (TR).

	Teaching Methods
	THE COURSE IS DIVIDED IN FRONTAL LESSONS (88 HOURS) AND IN-CLASS EXERCISES TO BE SCHEDULED DURING RECEPTION / TUTORING HOURS, ACCORDING TO THE LEARNING PERFORMANCE AND TO THE NEEDS OF SINGLE STUDENTS AND / OR THE CLASS. THE LESSONS WILL ALLOW THE STUDENT TO ACQUIRE THE BASIC KNOWLEDGE OF GENERAL CHEMISTRY AND ORGANIC CHEMISTRY, PREPARATORY FOR THE STUDY OF MOLECULAR MECHANISMS AT THE BASIS OF THE STRUCTURE, ORGANIZATION AND FUNCTIONS OF LIVING MATTER, MAIN SUBJECTS OF BIOCHEMISTRY AND OF BIOLOGICAL AND BIOMEDICAL DISCIPLINES. THE PRACTICAL EXERCISES WILL ALLOW THE STUDENT TO ACQUIRE SKILLS IN DESCRIBING AND ORGANIZING THE REACTIVITY OF THE MAIN FUNCTIONAL GROUPS OF ORGANIC CHEMISTRY IN ORDER TO UNDERSTAND MOLECULAR AND SUPRA-MOLECULAR INTERACTIONS.

Teaching Methods

THE COURSE IS DIVIDED IN FRONTAL LESSONS (88 HOURS) AND IN-CLASS EXERCISES TO BE SCHEDULED DURING RECEPTION / TUTORING HOURS, ACCORDING TO THE LEARNING PERFORMANCE AND TO THE NEEDS OF SINGLE STUDENTS AND / OR THE CLASS. THE LESSONS WILL ALLOW THE STUDENT TO ACQUIRE THE BASIC KNOWLEDGE OF GENERAL CHEMISTRY AND ORGANIC CHEMISTRY, PREPARATORY FOR THE STUDY OF MOLECULAR MECHANISMS AT THE BASIS OF THE STRUCTURE, ORGANIZATION AND FUNCTIONS OF LIVING MATTER, MAIN SUBJECTS OF BIOCHEMISTRY AND OF BIOLOGICAL AND BIOMEDICAL DISCIPLINES. THE PRACTICAL EXERCISES WILL ALLOW THE STUDENT TO ACQUIRE SKILLS IN DESCRIBING AND ORGANIZING THE REACTIVITY OF THE MAIN FUNCTIONAL GROUPS OF ORGANIC CHEMISTRY IN ORDER TO UNDERSTAND MOLECULAR AND SUPRA-MOLECULAR INTERACTIONS.

	Verification of learning
	THE EXAM CONSISTS OF A WRITTEN TEST AND AN ORAL TEST. IN THE WRITTEN TEST THE STUDENT WILL BE ASKED TO SOLVE EXERCISES AIMED AT VERIFYING THE STUDENT'S ABILITY TO APPLY THE KNOWLEDGE MATURED DURING THE COURSE TO NUMERICAL CALCULATION FOR THE SOLUTION OF SIMPLE PROBLEMS OF GENERAL CHEMISTRY AND STOICHIOMETRY, AND TO SOLVE QUESTIONS ABOUT THE STRUCTURE, PROPERTIES AND REACTIVITY OF ORGANIC COMPOUNDS AND MOLECULES OF BIOLOGICAL INTEREST. THE ORAL TEST WILL BE DEDICATED TO THE DISCUSSION OF THE WRITTEN ELABORATE AND TO THE VERIFICATION OF THE THEORETICAL KNOWLEDGE AND CRITICAL SKILLS DEVELOPED IN THE UNDERSTANDING OF CHEMICAL PHENOMENA AND OF THE STRUCTURE, FUNCTION AND REACTIVITY OF MOLECULES OF BIOLOGICAL, PHARMACEUTICAL AND MEDICAL INTEREST.

Verification of learning

THE EXAM CONSISTS OF A WRITTEN TEST AND AN ORAL TEST. IN THE WRITTEN TEST THE STUDENT WILL BE ASKED TO SOLVE EXERCISES AIMED AT VERIFYING THE STUDENT'S ABILITY TO APPLY THE KNOWLEDGE MATURED DURING THE COURSE TO NUMERICAL CALCULATION FOR THE SOLUTION OF SIMPLE PROBLEMS OF GENERAL CHEMISTRY AND STOICHIOMETRY, AND TO SOLVE QUESTIONS ABOUT THE STRUCTURE, PROPERTIES AND REACTIVITY OF ORGANIC COMPOUNDS AND MOLECULES OF BIOLOGICAL INTEREST.
THE ORAL TEST WILL BE DEDICATED TO THE DISCUSSION OF THE WRITTEN ELABORATE AND TO THE VERIFICATION OF THE THEORETICAL KNOWLEDGE AND CRITICAL SKILLS DEVELOPED IN THE UNDERSTANDING OF CHEMICAL PHENOMENA AND OF THE STRUCTURE, FUNCTION AND REACTIVITY OF MOLECULES OF BIOLOGICAL, PHARMACEUTICAL AND MEDICAL INTEREST.

	Texts
	L. BINAGLIA, B. GIARDINA, CHIMICA E PROPEDEUTICA BIOCHIMICA, 3^ ED., MCGRAW-HILL (ISBN 978 88 386 3971-5) F. A. BETTELHEIM, W. H. BROWN, M. K. CAMPBELL, S. O. FARRELL, O. J. TORRES CHIMICA E PROPEDEUTICA BIOCHIMICA, ED. EDISES (ISBN-9788879598415) T. BELLINI, CHIMICA MEDICA E PROPEDEUTICA BIOCHIMICA, ZANICHELLI (ISBN 978-88-08-25237-1) P. ATKINS, L. JONES, PRINCIPI DI CHIMICA. ZANICHELLI. J. MC MURRY: FONDAMENTI DI CHIMICA ORGANICA. ZANICHELLI M. STEFANI, N. TADDEI, CHIMICA, BIOCHIMICA E BIOLOGIA APPLICATA. ZANICHELLI MATERIALE DIDATTICO FORNITO DAL DOCENTE PER LA PARTE POLIMERI

Texts

L. BINAGLIA, B. GIARDINA, CHIMICA E PROPEDEUTICA BIOCHIMICA, 3^ ED., MCGRAW-HILL (ISBN 978 88 386 3971-5)
F. A. BETTELHEIM, W. H. BROWN, M. K. CAMPBELL, S. O. FARRELL, O. J. TORRES CHIMICA E PROPEDEUTICA BIOCHIMICA, ED. EDISES (ISBN-9788879598415)
T. BELLINI, CHIMICA MEDICA E PROPEDEUTICA BIOCHIMICA, ZANICHELLI (ISBN 978-88-08-25237-1)
P. ATKINS, L. JONES, PRINCIPI DI CHIMICA. ZANICHELLI.
J. MC MURRY: FONDAMENTI DI CHIMICA ORGANICA. ZANICHELLI
M. STEFANI, N. TADDEI, CHIMICA, BIOCHIMICA E BIOLOGIA APPLICATA. ZANICHELLI
MATERIALE DIDATTICO FORNITO DAL DOCENTE PER LA PARTE POLIMERI

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	FURTHER INFORMATION, PLEASE CONTACT THE TEACHERS: MARZULLO@UNISA.IT, GDELLAPORTA@UNISA.IT

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Giovanna DELLA PORTA | C.I. CHEMISTRY AND PROPAEDEUTIC BIOCHEMISTRY