Giovanna DELLA PORTA | Progetti

ASSEGNAZIONE PRIMA NOMINA DOTT.SSA DELLA PORTA GIOVANNA

Mesenchymal stem cells (MSC)-derived extracellular vesicles (EVs) remain a promising therapeutic tool thanks to their pro-regenerative properties and applicability as drug delivery systems, despite their drug loading limitations. Herein, we would like to developed MSC-EVs derived hybrid lipid nanoparticles (MSC-Hyb NPs) using a microfluidic technique as an alternative platform for the delivery of

The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and localize at target tissues. White blood cells of the immune systemâ¿¿known as leukocytesâ¿¿possess all of these properties and exert their targeting ability through cellular membrane interactions.The research activity will be focused on the dev

Microfluidic technology has achieved, recently, excellent results in term of liposome formation with a higher reproducible nano-sized vesicles, extremely narrow size distributions as well as nano-devices with SUV structure; furthermore, high protein loading and preserved biological activity were also reported.The goal of the research is to formulate with microfluidic technology a stable lipid na