Giovanna DELLA PORTA | Progetti

ASSEGNAZIONE PRIMA NOMINA DOTT.SSA DELLA PORTA GIOVANNA

Mesenchymal stem cells (MSC)-derived extracellular vesicles (EVs) remain a promising therapeutic tool thanks to their pro-regenerative properties and applicability as drug delivery systems, despite their drug loading limitations. Herein, we would like to developed MSC-EVs derived hybrid lipid nanoparticles (MSC-Hyb NPs) using a microfluidic technique as an alternative platform for the delivery of

Lâ¿¿esposizione a micro e nanoplastiche (MP/NP) derivate da plastiche biodegradabili di acido polilattico (PLA) potrebbe causare danni alla salute umana accumulandosi in cellule e tessuti e alterando i normali processi metabolici cellulari e tissutali. Il presente progetto si propone di studiare gli effetti di MP e NP di PLA in diversi modelli in vitro. In particolare obiettivi specifici sono: â¿¢Va

The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and localize at target tissues. White blood cells of the immune systemâ¿¿known as leukocytesâ¿¿possess all of these properties and exert their targeting ability through cellular membrane interactions.The research activity will be focused on the dev

The aim of this study consists in extract Tendon Progenitor Stem Cells (TPSCs) from surgical explant, optimize their culture, eventually also in dynamic conditions, and collecting extracellular vesicles from those primary cultures. First, the multipotency of TPCS will be evaluated by carrying out a multi-lineage differentiation study. Then, culture conditions will be optimized in order to promo