Giovanna DELLA PORTA | Progetti

ASSEGNAZIONE PRIMA NOMINA DOTT.SSA DELLA PORTA GIOVANNA

Mesenchymal stem cells (MSC)-derived extracellular vesicles (EVs) remain a promising therapeutic tool thanks to their pro-regenerative properties and applicability as drug delivery systems, despite their drug loading limitations. Herein, we would like to developed MSC-EVs derived hybrid lipid nanoparticles (MSC-Hyb NPs) using a microfluidic technique as an alternative platform for the delivery of

Lâ¿¿esposizione a micro e nanoplastiche (MP/NP) derivate da plastiche biodegradabili di acido polilattico (PLA) potrebbe causare danni alla salute umana accumulandosi in cellule e tessuti e alterando i normali processi metabolici cellulari e tissutali. Il presente progetto si propone di studiare gli effetti di MP e NP di PLA in diversi modelli in vitro. In particolare obiettivi specifici sono: â¿¢Va

The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and localize at target tissues. White blood cells of the immune systemâ¿¿known as leukocytesâ¿¿possess all of these properties and exert their targeting ability through cellular membrane interactions.The research activity will be focused on the dev

The aim of this study consists in extract Tendon Progenitor Stem Cells (TPSCs) from surgical explant, optimize their culture, eventually also in dynamic conditions, and collecting extracellular vesicles from those primary cultures. First, the multipotency of TPCS will be evaluated by carrying out a multi-lineage differentiation study. Then, culture conditions will be optimized in order to promo

Microfluidic technology has achieved, recently, excellent results in term of liposome formation with a higher reproducible nano-sized vesicles, extremely narrow size distributions as well as nano-devices with SUV structure; furthermore, high protein loading and preserved biological activity were also reported.The goal of the research is to formulate with microfluidic technology a stable lipid na

The proposed project firstly aims to set a successful extraction strategy of Tendon Stem/Progenitor Cells (TSPCs) from healthy and pathological tendon explants, investigating the possible morphological and gene expression modifications for pathological TSPCs, in comparison with cells extracted from healthy tissues. The second aim of the study consist in using both healthy and pathological tissue-d

Il sistema endocannabinoide (ECS) è un sistema che controlla numerose funzioni nel SNC. Scopo generale del presente progetto è studiare il ruolo dell'ECS nella neuroglia ed esaminare gli effetti della modulazione dell'ECS sulla capacità di astrociti e microglia di influenzare la proliferazione e il differenziamento neuronale. I risultati dello studio potranno contribuire alla comprensione della fu