Mariarosaria FALANGA | PHYSICS FOR BIOMEDICAL APPLICATIONS

cod. 0622700055

PHYSICS FOR BIOMEDICAL APPLICATIONS

	0622700055
	DIPARTIMENTO DI INGEGNERIA DELL'INFORMAZIONE ED ELETTRICA E MATEMATICA APPLICATA
	EQF7
	COMPUTER ENGINEERING
	2020/2021

PERCORSO COMUNE

	YEAR OF COURSE
	YEAR OF DIDACTIC SYSTEM 2017
	SECONDO SEMESTRE

TEACHING UNITS

SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
FIS/07	4	32	LESSONS	OPTIONAL SUBJECTS
FIS/07	2	16	LAB	OPTIONAL SUBJECTS

PROFESSORS

	MICHELE GUIDA T Curriculum
	MARIAROSARIA FALANGA Curriculum

	Objectives
	IT REPRESENTS AN ADVANCED COURSE ABOUT APPLIED PHYSICS TO BIOMEDICAL SCIENCES. IT IS FINALIZED TO PROVIDE THE KNOW-HOW ABOUT THE BIOMEDICAL APPLICATIONS OF THE EFFECTS OF THE INTERACTION OF BIOLOGICAL SYSTEMS WITH IONIZING AND NON-IONIZING RADIATIONS, MECHANICAL STRESSES AND VIBRATIONS, FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES, TOGETHER WITH THE ASSESSMENT OF THE HEALTH RISKS ASSOCIATED WITH HUMAN EXPOSURE TO POLLUTING PHYSICAL AGENTS LIKE IONIZING RADIATIONS, E.M. FIELDS, AND NOISE. AT THE END OF THE COURSE, THE STUDENTS WILL GAIN KNOWLEDGE, IN PARTICULAR, ABOUT: BASICS OF THE INTERACTION BETWEEN IONIZING AND NON-IONIZING RADIATIONS AND THE BIOLOGICAL MATTER. BASICS OF THE THEORY OF NON-LINEAR SELF-OSCILLATING SYSTEMS. CHARACTERISTICS OF THE MECHANICAL OSCILLATIONS IN BIOLOGICAL SYSTEMS. PRINCIPLES OF OPERATION OF RELEVANT ADVANCED BIOMEDICAL EQUIPMENTS FOR DIAGNOSTICS AND THERAPY. THE MAIN ABILITIES (THAT IS CAPACITIES TO APPLY THE GAINED KNOWLEDGE) ACHIEVED BY STUDENTS WILL BE: •TO BE ABLE TO OPERATE WITH DOSIMETRIC QUANTITIES; •TO BE ABLE TO APPLY THE THEORETICAL CONCEPTS TO SPECIFIC BIOLOGICAL CASES OF INTEREST; •TO BE ABLE TO ASSESS ALSO WITH THE HELP OF SIMPLE EXPERIMENTAL SESSIONS THE BIOLOGICAL IMPACT OF THE PHYSICAL PHENOMENA STUDIED DURING THE COURSE.

IT REPRESENTS AN ADVANCED COURSE ABOUT APPLIED PHYSICS TO BIOMEDICAL SCIENCES. IT IS FINALIZED TO PROVIDE THE KNOW-HOW ABOUT THE BIOMEDICAL APPLICATIONS OF THE EFFECTS OF THE INTERACTION OF BIOLOGICAL SYSTEMS WITH IONIZING AND NON-IONIZING RADIATIONS, MECHANICAL STRESSES AND VIBRATIONS, FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES, TOGETHER WITH THE ASSESSMENT OF THE HEALTH RISKS ASSOCIATED WITH HUMAN EXPOSURE TO POLLUTING PHYSICAL AGENTS LIKE IONIZING RADIATIONS, E.M. FIELDS, AND NOISE.
AT THE END OF THE COURSE, THE STUDENTS WILL GAIN KNOWLEDGE, IN PARTICULAR, ABOUT:
BASICS OF THE INTERACTION BETWEEN IONIZING AND NON-IONIZING RADIATIONS AND THE BIOLOGICAL MATTER.
BASICS OF THE THEORY OF NON-LINEAR SELF-OSCILLATING SYSTEMS.
CHARACTERISTICS OF THE MECHANICAL OSCILLATIONS IN BIOLOGICAL SYSTEMS.
PRINCIPLES OF OPERATION OF RELEVANT ADVANCED BIOMEDICAL EQUIPMENTS FOR DIAGNOSTICS AND THERAPY.
THE MAIN ABILITIES (THAT IS CAPACITIES TO APPLY THE GAINED KNOWLEDGE) ACHIEVED BY STUDENTS WILL BE:
•TO BE ABLE TO OPERATE WITH DOSIMETRIC QUANTITIES;
•TO BE ABLE TO APPLY THE THEORETICAL CONCEPTS TO SPECIFIC BIOLOGICAL CASES OF INTEREST;
•TO BE ABLE TO ASSESS ALSO WITH THE HELP OF SIMPLE EXPERIMENTAL SESSIONS THE BIOLOGICAL IMPACT OF THE PHYSICAL PHENOMENA STUDIED DURING THE COURSE.

	Prerequisites
	KNOWLEDGE OF PHYSICS AND MATHEMATICS GAINED DURING THE FIRST LEVEL (LAUREA TRIENNALE) UNIVERSITY PROGRAM.

	Contents
	PART I: INTERACTION OF IONIZING RADIATION WITH BIOLOGICAL SYSTEMS WEEK I BASICS OF ATOMIC AND NUCLEAR PHYSICS. RADIOATTIVITÀ E RADIAZIONI ALFA, BETA, E GAMMA - RADIOACTIVITY AND ALPHA, BETA AND GAMMA RADIATIONS. WEEK II ENVIROMENTAL RADIOACTIVITY AND NON-NUCLEAR INDUSTRY. NATURALLY OCCURRING RADIOACTIVE MATERIALS (NORM) AND TECHNOLOGICAL ENHANCED NATURALLY OCCURRING RADIOACTIVE MATERIALS (TENORM) WEEK III: BIOLOGICAL DAMAGES ASSOCIATED TO EXPOSURE TO IONIZING RADIATION WEEK IV: DOSIMETRY, HEALTH RISK AND NATIONAL/INTERNATIONAL LEGISLATION WEEK V APPLICATIONS: BIOLOGICAL DOSIMETRY WITH ALPHA RADIATION FROM ENVIRONMENTAL RADIOACTIVITY (IRBIS PROJECT) METHODS AND TECHNIQUES FOR ASSESSING THE ENVIRONMENTAL RADIOACTIVITY AND THE RELATED HEALTH RISK (RAD_CAMPANIA PROJECT) WEEK VI BIOMEDICAL EQUIPMENTS: COMPUTERIZED AXIAL TOMOGRAPHY CAT NUCLEAR MAGNETIC RESONANCE NMR. PART II: INTERACTION OF NON-IONIZING RADIATION (E.M.) WITH BIOLOGICAL SYSTEMS (BIOELECTROMAGNETIC INTERACTION). POPULATION AND WORKERS EXPOSURE TO: -BASE TRANSCEIVER STATIONS (BTS) -MOBILE PHONES -HOME AND INDUSTRIAL APPLIANCES BIOMEDICAL APPLICATIONS. PART III: OSCILLATIONS IN BIOLOGICAL SYSTEMS. THESE TOPICS WILL BE TAUGHT BY MEANS OF THEORETICAL LECTURES, AMOUNTING AT TWO THIRDS OF THE TOTAL NUMBER OF HOURS ACCOMPANIED BY AT LEAST 16 HOURS OF PRACTICAL ACTIVITIES IN THE CLASSROOM WITH STUDENTS ABOUT SPECIFIC PROJECTS REGARDING THE COURSE, PROPOSED BY THE PROFESSORS.

Contents

PART I: INTERACTION OF IONIZING RADIATION WITH BIOLOGICAL SYSTEMS
WEEK I
BASICS OF ATOMIC AND NUCLEAR PHYSICS.
RADIOATTIVITÀ E RADIAZIONI ALFA, BETA, E GAMMA - RADIOACTIVITY AND ALPHA, BETA AND GAMMA RADIATIONS.
WEEK II
ENVIROMENTAL RADIOACTIVITY AND NON-NUCLEAR INDUSTRY.
NATURALLY OCCURRING RADIOACTIVE MATERIALS (NORM) AND TECHNOLOGICAL ENHANCED NATURALLY OCCURRING RADIOACTIVE MATERIALS (TENORM)
WEEK III:
BIOLOGICAL DAMAGES ASSOCIATED TO EXPOSURE TO IONIZING RADIATION
WEEK IV: DOSIMETRY, HEALTH RISK AND NATIONAL/INTERNATIONAL LEGISLATION
WEEK V
APPLICATIONS:
BIOLOGICAL DOSIMETRY WITH ALPHA RADIATION FROM ENVIRONMENTAL RADIOACTIVITY (IRBIS PROJECT)
METHODS AND TECHNIQUES FOR ASSESSING THE ENVIRONMENTAL RADIOACTIVITY AND THE RELATED HEALTH RISK (RAD_CAMPANIA PROJECT)
WEEK VI
BIOMEDICAL EQUIPMENTS:
COMPUTERIZED AXIAL TOMOGRAPHY CAT
NUCLEAR MAGNETIC RESONANCE NMR.
PART II: INTERACTION OF NON-IONIZING RADIATION (E.M.) WITH BIOLOGICAL SYSTEMS (BIOELECTROMAGNETIC INTERACTION).
POPULATION AND WORKERS EXPOSURE TO:
-BASE TRANSCEIVER STATIONS (BTS)
-MOBILE PHONES
-HOME AND INDUSTRIAL APPLIANCES
BIOMEDICAL APPLICATIONS.
PART III: OSCILLATIONS IN BIOLOGICAL SYSTEMS.
THESE TOPICS WILL BE TAUGHT BY MEANS OF THEORETICAL LECTURES, AMOUNTING AT TWO THIRDS OF THE TOTAL NUMBER OF HOURS ACCOMPANIED BY AT LEAST 16 HOURS OF PRACTICAL ACTIVITIES IN THE CLASSROOM WITH STUDENTS ABOUT SPECIFIC PROJECTS REGARDING THE COURSE, PROPOSED BY THE PROFESSORS.

	Teaching Methods
	THE DEPLOYMENT OF THE COURSE IS ARTICULATED IN FRONT CLASS-ROOM LECTURES (THEORY (32 HOURS) AND PRACTICE/PROJECT ACTIVITIES, AT LEAST 16 HOURS), FOR A TOTAL DURATION OF 48 HOURS (6 CFU), DIVIDED INTO 12 WEEKS, PERFORMED IN THE CLASS-ROOM ALSO WITH THE HELP OF MULTIMEDIA MATERIAL AND LABORATORY EXPERIMENTS.

	Verification of learning
	AT THE END OF THE COURSE THE LEARNING VERIFICATION IS AIMED AT THE ASSESSMENT THE KNOWLEDGE AND KNOW-HOW GAINED BY THE STUDENTS ABOUT THE CONCEPTS ILLUSTRATED AND THEIR CAPABILITY TO USE SUCH KNOW-HOW TO THE BIOMEDICAL APPLICATIONS OF INTEREST. SUCH VERIFICATION WILL BE PERFORMED WITH AN ORAL EXAM. DURING THE EXAM THE GAINED KNOWLEDGE OF THE TOPICS ILLUSTRATED DURING THE COURSE, THE SKILLS CONSISTING IN: GRASP OF THE ISSUES, CORRECT AND PROPER USE OF THE SCIENTIFIC LANGUAGE, ABILITY TO ANALYSE, COMMUNICATE AND DRAW CONCLUSIONS WILL BE EVALUATED . THE FINAL EVALUATION IS EXPRESSED IN THIRTY. AN EVALUATION OF MAGNA CUM LAUDE CAN BE GIVEN TO CANDIDATES SHOWING EXCELLENT ANALYTICAL ABILITIES.

Verification of learning

AT THE END OF THE COURSE THE LEARNING VERIFICATION IS AIMED AT THE ASSESSMENT THE KNOWLEDGE AND KNOW-HOW GAINED BY THE STUDENTS ABOUT THE CONCEPTS ILLUSTRATED AND THEIR CAPABILITY TO USE SUCH KNOW-HOW TO THE BIOMEDICAL APPLICATIONS OF INTEREST.
SUCH VERIFICATION WILL BE PERFORMED WITH AN ORAL EXAM.
DURING THE EXAM THE GAINED KNOWLEDGE OF THE TOPICS ILLUSTRATED DURING THE COURSE, THE SKILLS CONSISTING IN:
GRASP OF THE ISSUES, CORRECT AND PROPER USE OF THE SCIENTIFIC LANGUAGE, ABILITY TO ANALYSE, COMMUNICATE AND DRAW CONCLUSIONS WILL BE EVALUATED .
THE FINAL EVALUATION IS EXPRESSED IN THIRTY. AN EVALUATION OF MAGNA CUM LAUDE CAN BE GIVEN TO CANDIDATES SHOWING EXCELLENT ANALYTICAL ABILITIES.

	Texts
	LECTURE NOTES AND MULTIMEDIA MATERIAL ON THE E-LEARNING PLATFORM MOODLE. SUGGESTED TEXTBOOKS: PART I: AA.VV. 2010. "RADIATION BIOLOGY: A HANDBOOK FOR TEACHERS AND STUDENTS", IAEA TRAINING COURSE SERIES 42, INTERNATIONAL ATOMIC ENERGY AGENCY IAEA, WIEN, 2010. C. POLVANI, 1993. "ELEMENTI DI RADIOPROTEZIONE, ENEA, ROMA , 1993. PART II: M FUNARO, M GUIDA, M MARINARO, I RABBUFFO (EDS.), 2000. "CAMPI ELETTROMAGNETICI E LORO INTERAZIONE CON I SISTEMI BIOLOGICI". ATTI DELLE GIORNATE DI STUDIO 23-24 NOV. 2000, UNIVERSITÀ DEGLI STUDI DI SALERNO. LIGUORI EDITORE 2000. L. CONFESSORE ET AL., 2017. "CAMPI ELETTROMAGNETICI -- VALUTAZIONE DEI RISCHI, EFFETTI E SORVEGLIANZA SANITARIA AI SENSI DEL D.LGS.159/2016". EPC EDITORE, 2017. PARTE III: ELEMENTARY REFERENCE TEXTBOOK FOR BEGINNERS: F S CRAWFORD, 1972. "ONDE ED OSCILLAZIONI" LA FISICA DI BERKELEY, VOL. 3, ZANICHELLI, BOLOGNA, 1972. SELECTED CHAPTERS FROM THE FOLLOWING TEXTBOOKS: E. OTT, 2002 “CHAOS IN DYNAMICAL SYSTEMS”, CAMBRIDGE UNIVERSITY PRESS; 2 EDIZIONE (22 AGOSTO 2002) P. CASTELLINI, E P TOMASINI AND GM REVEL, 2001 “LASER BASED MEASUREMENT” IN “ENCYCLOPAEDIA OF VIBRATION” (EDITED BY SIMON G BRAUN ET AL.) (LONDON: ACADEMIC). SUGGESTED ADVANCED READINGS: PART I: GUIDA DOMENICO; GUIDA MICHELE; CUOMO ALBINA; GUADAGNUOLO DAVIDE; SIERVO VINCENZO. 2013. "ASSESSMENT AND MAPPING OF RADON-PRONE AREAS ON A REGIONAL SCALE AS APPLICATION OF A HIERARCHICAL ADAPTIVE AND MULTI-SCALE APPROACH FORTHE ENVIRONMENTAL PLANNING. CASE STUDY OF CAMPANIA REGION, SOUTHERN ITALY". WSEAS TRANSACTIONS ON SYSTEMS. VOL. 12. PAG.105-120, 2013. JULIE A. REISZ, NIDHI BANSAL, JIANG QIAN, WEILING ZHAO, AND CRISTINA M. FURDUI. 2014. "EFFECTS OF IONIZING RADIATION ON BIOLOGICAL MOLECULES—MECHANISMS OF DAMAGE AND EMERGING METHODS OF DETECTION". FORUM REVIEW ARTICLE. ANTIOXIDANTS & REDOX SIGNALING VOLUME 21, NUMBER 2, 2014, DOI: 10.1089/ARS.2013.5489. PART II: MANCINI, S.; CALIENDO, E.; GUIDA, M.; BISCEGLIA, B. 2017. "PRELIMINARY ASSESSMENT, BY MEANS OF RADON EXHALATION RATE MEASUREMENTS, OF THE BIO-SUSTAINABILITY OF MICROWAVE TREATMENT TO ELIMINATE BIODETERIOGENS INFESTING STONE WALLS OF MONUMENTAL HISTORICAL BUILDINGS". IN: IOP CONFERENCE SERIES: MATERIALS SCIENCE AND ENGINEERING INSTITUTE OF PHYSICS PUBLISHING VOL.251, PAG.1-7, 3RD INTERNATIONAL CONFERENCE ON INNOVATIVE MATERIALS, STRUCTURES AND TECHNOLOGIES, IMST 2017, RIGA, LETTONIA 27–29 SEPTEMBER 2017. DIGITAL OBJECT IDENTIFIER (DOI): 10.1088/1757-899X/251/1/012026 PARTE III: G BUCCHERI , E DE LAURO E, S DE MARTINO, M FALANGA, EXPERIMENTAL STUDY OF SELF-OSCILLATIONS OF THE TRACHEA–LARYNX TRACT BY LASER DOPPLER VIBROMETRY, BIOMEDICAL PHYSICS & ENGINEERING EXPRESS 2 (5), 055009, 2016.

Texts

LECTURE NOTES AND MULTIMEDIA MATERIAL ON THE E-LEARNING PLATFORM MOODLE.
SUGGESTED TEXTBOOKS:
PART I:
AA.VV. 2010. "RADIATION BIOLOGY: A HANDBOOK FOR TEACHERS AND STUDENTS", IAEA TRAINING COURSE SERIES 42, INTERNATIONAL ATOMIC ENERGY AGENCY IAEA, WIEN, 2010.
C. POLVANI, 1993. "ELEMENTI DI RADIOPROTEZIONE, ENEA, ROMA , 1993.
PART II:
M FUNARO, M GUIDA, M MARINARO, I RABBUFFO (EDS.), 2000. "CAMPI ELETTROMAGNETICI E LORO INTERAZIONE CON I SISTEMI BIOLOGICI". ATTI DELLE GIORNATE DI STUDIO 23-24 NOV. 2000, UNIVERSITÀ DEGLI STUDI DI SALERNO. LIGUORI EDITORE 2000.
L. CONFESSORE ET AL., 2017. "CAMPI ELETTROMAGNETICI -- VALUTAZIONE DEI RISCHI, EFFETTI E SORVEGLIANZA SANITARIA AI SENSI DEL D.LGS.159/2016". EPC EDITORE, 2017.
PARTE III:
ELEMENTARY REFERENCE TEXTBOOK FOR BEGINNERS:
F S CRAWFORD, 1972. "ONDE ED OSCILLAZIONI" LA FISICA DI BERKELEY, VOL. 3, ZANICHELLI, BOLOGNA, 1972.
SELECTED CHAPTERS FROM THE FOLLOWING TEXTBOOKS:
E. OTT, 2002 “CHAOS IN DYNAMICAL SYSTEMS”, CAMBRIDGE UNIVERSITY PRESS; 2 EDIZIONE (22 AGOSTO 2002)
P. CASTELLINI, E P TOMASINI AND GM REVEL, 2001 “LASER BASED MEASUREMENT” IN “ENCYCLOPAEDIA OF VIBRATION” (EDITED BY SIMON G BRAUN ET AL.) (LONDON: ACADEMIC).
SUGGESTED ADVANCED READINGS:
PART I:
GUIDA DOMENICO; GUIDA MICHELE; CUOMO ALBINA; GUADAGNUOLO DAVIDE; SIERVO VINCENZO. 2013. "ASSESSMENT AND MAPPING OF RADON-PRONE AREAS ON A REGIONAL SCALE AS APPLICATION OF A HIERARCHICAL ADAPTIVE AND MULTI-SCALE APPROACH FORTHE ENVIRONMENTAL PLANNING. CASE STUDY OF CAMPANIA REGION, SOUTHERN ITALY". WSEAS TRANSACTIONS ON SYSTEMS. VOL. 12. PAG.105-120, 2013.
JULIE A. REISZ, NIDHI BANSAL, JIANG QIAN, WEILING ZHAO, AND CRISTINA M. FURDUI. 2014. "EFFECTS OF IONIZING RADIATION ON BIOLOGICAL MOLECULES—MECHANISMS OF DAMAGE AND EMERGING METHODS OF DETECTION". FORUM REVIEW ARTICLE. ANTIOXIDANTS & REDOX SIGNALING
VOLUME 21, NUMBER 2, 2014, DOI: 10.1089/ARS.2013.5489.
PART II:
MANCINI, S.; CALIENDO, E.; GUIDA, M.; BISCEGLIA, B. 2017. "PRELIMINARY ASSESSMENT, BY MEANS OF RADON EXHALATION RATE MEASUREMENTS, OF THE BIO-SUSTAINABILITY OF MICROWAVE TREATMENT TO ELIMINATE BIODETERIOGENS INFESTING STONE WALLS OF MONUMENTAL HISTORICAL BUILDINGS". IN: IOP CONFERENCE SERIES: MATERIALS SCIENCE AND ENGINEERING INSTITUTE OF PHYSICS PUBLISHING VOL.251, PAG.1-7, 3RD INTERNATIONAL CONFERENCE ON INNOVATIVE MATERIALS, STRUCTURES AND TECHNOLOGIES, IMST 2017, RIGA, LETTONIA 27–29 SEPTEMBER 2017.
DIGITAL OBJECT IDENTIFIER (DOI): 10.1088/1757-899X/251/1/012026
PARTE III:
G BUCCHERI , E DE LAURO E, S DE MARTINO, M FALANGA, EXPERIMENTAL STUDY OF SELF-OSCILLATIONS OF THE
TRACHEA–LARYNX TRACT BY LASER DOPPLER VIBROMETRY, BIOMEDICAL PHYSICS & ENGINEERING EXPRESS 2 (5),
055009, 2016.

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Mariarosaria FALANGA | PHYSICS FOR BIOMEDICAL APPLICATIONS