Mario Felice TECCE | BIOCHIMICA GENERALE

cod. 0760100012

BIOCHIMICA GENERALE

	0760100012
	DIPARTIMENTO DI FARMACIA
	CORSO DI LAUREA MAGISTRALE A CICLO UNICO DI 5 ANNI
	PHARMACY
	2014/2015

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 2
	YEAR OF DIDACTIC SYSTEM 2010
	SECONDO SEMESTRE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	BIOCHIMICA GENERALE MOD. 1 MODULO DI BIOCHIMICA GENERALE
	BIO/10	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
2	BIOCHIMICA GENERALE MOD. 2 MODULO DI BIOCHIMICA GENERALE
	BIO/10	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	ALESSANDRA ROSATI1 T Curriculum
	MARIO FELICE TECCE21 Curriculum
	MARIA ANTONIETTA BELISARIO2 Curriculum

	Objectives
	THE COURSE AIMS TO PROVIDE KNOWLEDGE ON THE STRUCTURE AND FUNCTION OF THE MAJOR BIOMOLECULES AND ON THE MAIN STREETS OF THE ENERGY METABOLISM; SUCH KNOWLEDGE IS ESSENTIAL TO THE UNDERSTANDING OF THE BIOLOGICAL MECHANISM OF DRUGS AND OF THE APPLICATION OF BIOCHEMICAL TECHNIQUES IN INDUSTRY. KNOWLEDGE AND UNDERSTANDING: ACQUISITION OF THE SPECIFIC LANGUAGE IN THE SECTOR AND OF THE BASIC PRINCIPLES OF THE DISCIPLINE. APPLYING KNOWLEDGE AND UNDERSTANDING: BE ABLE TO ASSESS IN AN INDEPENDENT AND CRITICAL WAY ANY DIFFERENT OPINIONS EXIST IN CERTAIN TOPICS ADDRESSED DURING THE LESSONS; MAKING JUDGEMENTS: ABILITY TO DISCUSS IN A CRITICAL AND AUTONOMOUS WAY, TOPICS COVERED IN THE COURSE. COMMUNICATION SKILLS: STUDENTS HAVE TO INTERACT WITH EXPERTS FROM OTHER DISCIPLINES IN THE FIELD, TO COMMUNICATE THE RESULTS OF THEIR LEARNING EFFECTIVELY.

THE COURSE AIMS TO PROVIDE KNOWLEDGE ON THE STRUCTURE AND FUNCTION OF THE MAJOR BIOMOLECULES AND ON THE MAIN STREETS OF THE ENERGY METABOLISM; SUCH KNOWLEDGE IS ESSENTIAL TO THE UNDERSTANDING OF THE BIOLOGICAL MECHANISM OF DRUGS AND OF THE APPLICATION OF BIOCHEMICAL TECHNIQUES IN INDUSTRY.
KNOWLEDGE AND UNDERSTANDING: ACQUISITION OF THE SPECIFIC LANGUAGE IN THE SECTOR AND OF THE BASIC PRINCIPLES OF THE DISCIPLINE.
APPLYING KNOWLEDGE AND UNDERSTANDING: BE ABLE TO ASSESS IN AN INDEPENDENT AND CRITICAL WAY ANY DIFFERENT OPINIONS EXIST IN CERTAIN TOPICS ADDRESSED DURING THE LESSONS;
MAKING JUDGEMENTS: ABILITY TO DISCUSS IN A CRITICAL AND AUTONOMOUS WAY, TOPICS COVERED IN THE COURSE.
COMMUNICATION SKILLS: STUDENTS HAVE TO INTERACT WITH EXPERTS FROM OTHER DISCIPLINES IN THE FIELD, TO COMMUNICATE THE RESULTS OF THEIR LEARNING EFFECTIVELY.

	Prerequisites
	KNOWLEDGE OF BASIC CONCEPTS OF BIOLOGY AND ORGANIC CHEMISTRY

	Contents
	INTRODUCTION TO BIOCHEMISTRY. COMPOSITION OF ORGANISMS: THE MOLECULES OF LIVING MATTER. THE PROPERTIES OF WATER. AMINO ACIDS: STRUCTURE, PROPERTIES AND CLASSIFICATION. PEPTIDE BOND. PROTEINS: STRUCTURE, CONFORMATION AND FUNCTION. HEMOGLOBIN, MYOGLOBIN, IMMUNOGLOBULINS. ENZYMES: STRUCTURE AND FUNCTION, ENZYME KINETICS, ENZYME INHIBITION. VITAMINS AND COENZYMES. NUCLEIC ACIDS: STRUCTURE AND FUNCTION, DNA REPLICATION, TRANSCRIPTION AND TRANSLATION. BIOENERGETICS AND METABOLISM: TRANSFER OF PHOSPHATE GROUPS AND ATP, BIOLOGICAL REDOX REACTIONS. GLUCOSE METABOLISM: GLYCOLYSIS, GLUCONEOGENESIS, GLYCOGEN METABOLISM, PENTOSE PHOSPHATE PATHWAY. OXIDATIVE DECARBOXYLATION OF PYRUVATE. THE CITRIC ACID CYCLE. LIPID METABOLISM: BIOSYNTHESIS AND CATABOLISM OF FATTY ACIDS. SYNTHESIS OF KETONE BODIES. CATABOLISM OF AMINO ACIDS AND UREA PRODUCTION. RESPIRATORY CHAIN AND OXIDATIVE PHOSPHORYLATION. METABOLIC REGULATION AND REGULATION OF GENE EXPRESSION. SYSTEM BIOCHEMISTRY: GENOMICS, PROTEOMICS AND METABOLOMICS.

Contents

INTRODUCTION TO BIOCHEMISTRY. COMPOSITION OF ORGANISMS: THE MOLECULES OF LIVING MATTER. THE PROPERTIES OF WATER. AMINO ACIDS: STRUCTURE, PROPERTIES AND CLASSIFICATION. PEPTIDE BOND. PROTEINS: STRUCTURE, CONFORMATION AND FUNCTION. HEMOGLOBIN, MYOGLOBIN, IMMUNOGLOBULINS. ENZYMES: STRUCTURE AND FUNCTION, ENZYME KINETICS, ENZYME INHIBITION. VITAMINS AND COENZYMES. NUCLEIC ACIDS: STRUCTURE AND FUNCTION, DNA REPLICATION, TRANSCRIPTION AND TRANSLATION. BIOENERGETICS AND METABOLISM: TRANSFER OF PHOSPHATE GROUPS AND ATP, BIOLOGICAL REDOX REACTIONS. GLUCOSE METABOLISM: GLYCOLYSIS, GLUCONEOGENESIS, GLYCOGEN METABOLISM, PENTOSE PHOSPHATE PATHWAY. OXIDATIVE DECARBOXYLATION OF PYRUVATE. THE CITRIC ACID CYCLE. LIPID METABOLISM: BIOSYNTHESIS AND CATABOLISM OF FATTY ACIDS. SYNTHESIS OF KETONE BODIES. CATABOLISM OF AMINO ACIDS AND UREA PRODUCTION. RESPIRATORY CHAIN AND OXIDATIVE PHOSPHORYLATION. METABOLIC REGULATION AND REGULATION OF GENE EXPRESSION. SYSTEM BIOCHEMISTRY: GENOMICS, PROTEOMICS AND METABOLOMICS.

	Teaching Methods
	LECTURES, INTERACTIVE TEACHING, TUTORIALS, THEORETICAL-PRACTICAL

	Verification of learning
	WRITTEN EXAMINATION IN ITINERE; ORAL FINAL EXAMINATION

	Texts
	D.VOET AND J.C.VOET BIOCHIMICA ED ZANICHELLI L.STRAYER BLOCHMICA 4RD ED. ZANICHELLI J.D.RAWN BIOCHIMICA ED. MCGRAW HILI

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Mario Felice TECCE | BIOCHIMICA GENERALE