Sabrina CASTELLANO | Progetti

Epimutations play a central role in the etiology of human cancers. In contrast to DNA mutations, passively inherited through DNA replication, epimutations must be actively maintained because of their reversibility. Together with the acetylation/deacetylation process, the methylation/demethylation of histone tails play a key role in the regulation of gene expression. Such mechanisms are tuned and c

Epimutations play a central role in the etiology of human cancers. In contrast to DNA mutations, passively inherited through DNA replication, epimutations must be actively maintained because of their reversibility. Together with the acetylation/deacetylation process, the methylation/demethylation of histone tails play a key role in the regulation of gene expression. Such mechanisms are tuned and c

High quality chemical probes of HKMTs, as tools for deciphering their physiological functions and roles in human diseases and testing therapeutic hypotheses, are critical for advancing this promising field. To date, potent selective inhibitors of PKMTs are known, nevertheless rarely they can be considered useful chemical probes. The aim of this project is to identify new modulators of PKMTs, with