Pietro CAMPIGLIA | MEDICINAL CHEMISTRY I

cod. 0760100015

MEDICINAL CHEMISTRY I

	0760100015
	DIPARTIMENTO DI FARMACIA
	EQF7
	PHARMACY
	2019/2020

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 3
	YEAR OF DIDACTIC SYSTEM 2016
	PRIMO SEMESTRE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
	CHIM/08	10	80	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	PIETRO CAMPIGLIA T Curriculum
	MARIA CARMINA SCALA Curriculum

	Objectives
	The course is aimed at acquiring knowledge and understanding of the various synthesis steps, the mechanisms of action of 'ADME of antibiotics, anti-cancer. antifungals, antiseptics, disinfectants, anti-viral and antimalarici.Lo student applying the acquired skills to be able to interpret and analyze the structure of the drugs and their pharmacological activities, and phases that govern research in the chemical-pharmaceutical field from the discovery of lead compound the placing on the market.

The course is aimed at acquiring knowledge and understanding of the various synthesis steps, the mechanisms of action of 'ADME of antibiotics, anti-cancer. antifungals, antiseptics, disinfectants, anti-viral and antimalarici.Lo student applying the acquired skills to be able to interpret and analyze the structure of the drugs and their pharmacological activities, and phases that govern research in the chemical-pharmaceutical field from the discovery of lead compound the placing on the market.

	Prerequisites
	ACQUISITION REQUIRED FOR THE FOLLOWING DISCIPLINES: ORGANIC CHEMISTRY AND BIOCHEMISTRY

	Contents
	DEFINITION OF DRUG; THE ACTIVE INGREDIENT AND PHARMACEUTICAL FORMS. DRUG DISCOVERY; THE MODERN TECHNOLOGIES IN DISCOVERY AND DRUG DEVELOPMENT. DRUGS FROM NATURAL AND SYNTHETIC ORIGIN. PHYSICO-CHEMICAL PROPERTIES OF DRUGS. PHARMACOKINETICS ; INTERACTIONS AMONG DRUGS AND AMONG DRUGS AND FOODS. BIOAVAILABILITY AND BIOEQUIVALENCE. PATENT. GENERIC DRUG. PHARMACODYNAMICS. AGONISTS, ANTAGONISTS, PARTIAL AGONISTS AND INVERSE AGONISTS. DRUG-METABOLIC INDUCTION AND INHIBITION. ENZYME INHIBITION. AIFA, EMEA, ORIGIN OF THE NAME OF THE DRUGS. INFLUENCE OF ISOMERISM ( OPTICAL , GEOMETRICAL AND CONFORMATIONAL) ON THE PHARMACOLOGICAL ACTIVITY. SPECIAL SECTION: ANTISEPTICS AND DISINFECTANTS. SULFA- DRUGS. ANTIBIOTICS . INHIBITOR VIRUS. MEDICAMENTS FOR TREATMENT OF AIDS. DRUGS USED FOR INFECTIONS WITH HEPATITIS B AND C. ANTICANCER DRUGS. ANTIFUNGALS; ANTIPROTOZOAN, PESTICIDES. EPIGENETIC DRUGS.

Contents

DEFINITION OF DRUG; THE ACTIVE INGREDIENT AND PHARMACEUTICAL FORMS. DRUG DISCOVERY; THE MODERN TECHNOLOGIES IN DISCOVERY AND DRUG DEVELOPMENT. DRUGS FROM NATURAL AND SYNTHETIC ORIGIN. PHYSICO-CHEMICAL PROPERTIES OF DRUGS. PHARMACOKINETICS ; INTERACTIONS AMONG DRUGS AND AMONG DRUGS AND FOODS. BIOAVAILABILITY AND BIOEQUIVALENCE. PATENT. GENERIC DRUG. PHARMACODYNAMICS. AGONISTS, ANTAGONISTS, PARTIAL AGONISTS AND INVERSE AGONISTS. DRUG-METABOLIC INDUCTION AND INHIBITION. ENZYME INHIBITION. AIFA, EMEA, ORIGIN OF THE NAME OF THE DRUGS. INFLUENCE OF ISOMERISM ( OPTICAL , GEOMETRICAL AND CONFORMATIONAL) ON THE PHARMACOLOGICAL ACTIVITY.
SPECIAL SECTION: ANTISEPTICS AND DISINFECTANTS. SULFA- DRUGS. ANTIBIOTICS . INHIBITOR VIRUS. MEDICAMENTS FOR TREATMENT OF AIDS. DRUGS USED FOR INFECTIONS WITH HEPATITIS B AND C. ANTICANCER DRUGS. ANTIFUNGALS; ANTIPROTOZOAN, PESTICIDES. EPIGENETIC DRUGS.

	Teaching Methods
	80 HOURS OF CLASSROOM LESSONS ARE PROVIDED ON ALL THE SUBJECTS OF THE COURSE.

	Verification of learning
	ACHIEVEMENT OF THE OBJECTIVES IS CERTIFIED BY PASSING AN EXAM.THE EXAM PROVIDES FOR A PRELIMINARY WRITTEN EXAM TO AN ORAL EXAM THAT TAKES PLACE ON DIFFERENT CALENDARED DAYS. THE WRITTEN TEST CONSISTS OF FIVE ANSWER AND IT HAS A DURATION NOT EXCEEDING 120 MINUTES AND IS AIMED AT VERIFYING THE ABILITY TO PROPERLY APPLY THEORETICAL KNOWLEDGE AND THE ABILITY TO COMMUNICATE IN WRITING. THE ORAL TEST CONSISTS OF A 40-MINUTE DISCUSSION AIMED AT ASSESSING THE LEVEL OF KNOWLEDGE AND UNDERSTANDING ACQUIRED BY THE STUDENT ON THE THEORETICAL CONTENTS OF THE PROGRAM. THE ORAL TEST WILL ALSO ALLOW STUDENTS TO COMMUNICATE WITH THE LANGUAGE SKILLS AND AUTONOMOUS EXPOSURE ORGANIZATION ON THE SAME SUBJECTS WITH THEORETICAL CONTENT.

Verification of learning

ACHIEVEMENT OF THE OBJECTIVES IS CERTIFIED BY PASSING AN EXAM.THE EXAM PROVIDES FOR A PRELIMINARY WRITTEN EXAM TO AN ORAL EXAM THAT TAKES PLACE ON DIFFERENT CALENDARED DAYS. THE WRITTEN TEST CONSISTS OF FIVE ANSWER AND IT HAS A DURATION NOT EXCEEDING 120 MINUTES AND IS
AIMED AT VERIFYING THE ABILITY TO PROPERLY APPLY THEORETICAL KNOWLEDGE AND THE ABILITY TO COMMUNICATE IN WRITING. THE ORAL TEST CONSISTS OF A 40-MINUTE DISCUSSION AIMED AT ASSESSING THE LEVEL OF KNOWLEDGE AND UNDERSTANDING ACQUIRED BY THE STUDENT ON THE THEORETICAL CONTENTS OF THE PROGRAM. THE ORAL TEST WILL ALSO ALLOW STUDENTS TO COMMUNICATE WITH THE LANGUAGE SKILLS AND AUTONOMOUS EXPOSURE ORGANIZATION ON THE SAME SUBJECTS WITH THEORETICAL CONTENT.

	Texts
	D.A. WILLIAMS, T.L. LEMKE, FOYE’S PRINCIPI DI CHIMICA FARMACEUTICA, PICCIN. • G.L. PATRICK, INTRODUZIONE ALLA CHIMICA FARMACEUTICA, EDISES, II EDIZIONE • WILSON&GISVOLD CHIMICA FARMACEUTICA .ED.CEA • T. NOGRADY, D. WEAVER, MEDICINAL CHEMISTRY – A MOLECULAR AND BIOCHEMICAL APPROACH, 3RD ED., OXFORD UNIVERSITY PRESS. • MONOGRAFIE DELLA COLLANA "CHIMICA DEI RECETTORI", EDITORE C. MELCHIORRE, CLUEB (BOLOGNA). • C. WERMUTH, LE APPLICAZIONI DELLA CHIMICA FARMACEUTICA, EDISES. • P. KROGSGAARD-LARSEN, T. LILJEFORS, U. MADSEN ED., TEXTBOOK OF DRUG DESIGN AND DISCOVERY, TAYLOR & FRANCIS. • GOODMAN & GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, TWELFTH EDITION, MCGRAW-HILL MEDICAL PUBLISHING DIVISION (2011). • WILSON AND GISVOLD'S TEXTBOOK OF ORGANIC MEDICINAL AND PHARMACEUTICAL CHEMISTRY-LIPPINCOTT WILLIAMS & WILKINS • KLEEMANN, ENGEL, KUTSCHER, REICHERT, PHARMACEUTICAL SUBSTANCES, 5TH ED., THIEME VERLAG. • BURGER’S MEDICINAL CHEMISTRY, DRUG DISCOVERY AND DEVELOPMENT. 7TH EDITION. WILEY. JOURNAL OF MEDICINAL CHEMISTRY, ACS.

Texts

D.A. WILLIAMS, T.L. LEMKE, FOYE’S PRINCIPI DI CHIMICA FARMACEUTICA, PICCIN.
• G.L. PATRICK, INTRODUZIONE ALLA CHIMICA FARMACEUTICA, EDISES, II EDIZIONE
• WILSON&GISVOLD CHIMICA FARMACEUTICA .ED.CEA
• T. NOGRADY, D. WEAVER, MEDICINAL CHEMISTRY – A MOLECULAR AND BIOCHEMICAL APPROACH, 3RD ED.,
OXFORD UNIVERSITY PRESS.
• MONOGRAFIE DELLA COLLANA "CHIMICA DEI RECETTORI", EDITORE C. MELCHIORRE, CLUEB (BOLOGNA).
• C. WERMUTH, LE APPLICAZIONI DELLA CHIMICA FARMACEUTICA, EDISES.
• P. KROGSGAARD-LARSEN, T. LILJEFORS, U. MADSEN ED., TEXTBOOK OF DRUG DESIGN AND DISCOVERY, TAYLOR
& FRANCIS.
• GOODMAN & GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, TWELFTH EDITION, MCGRAW-HILL
MEDICAL PUBLISHING DIVISION (2011).
• WILSON AND GISVOLD'S TEXTBOOK OF ORGANIC MEDICINAL AND PHARMACEUTICAL CHEMISTRY-LIPPINCOTT
WILLIAMS & WILKINS
• KLEEMANN, ENGEL, KUTSCHER, REICHERT, PHARMACEUTICAL SUBSTANCES, 5TH ED., THIEME VERLAG.
• BURGER’S MEDICINAL CHEMISTRY, DRUG DISCOVERY AND DEVELOPMENT. 7TH EDITION. WILEY. JOURNAL OF
MEDICINAL CHEMISTRY, ACS.

	More Information
	THE COURSE IS TAUGHT IN ITALIAN THE ATTENDANCE IS MANDATORY LOCATION: DEPARTMENT OF PHARMACY

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Pietro CAMPIGLIA | MEDICINAL CHEMISTRY I