Ciro MILITE | Curriculum
Ciro MILITE Curriculum
Training
Ciro Milite received his Master of Science degree (M.Sc.) in Pharmaceutical Chemistry in 2007 at the University of Salerno.
He continued his training at the same University obtaining, in 2011, the PhD in Medicinal Chemistry with a thesis entitled "Design, synthesis and biological evaluation of new small molecule modulators of arginine methyltransferases."
Academic Positions and Research Experiences
In 2010 Ciro Milite spent a period as visiting scientist at the laboratories of prof. Carlos Barbas III of "The Scripps Research Institute", La Jolla, California to expand his knowledge in the field of organocatalyzed enantioselective chemical reactions.
From 2012 to 2015 he obtained a research grant at the Department of Pharmacy, University of Salerno, dealing with the design, synthesis and evaluation of the biological activity of small-molecule modulators of histone methylation. Subsequently he worked on the development of models and methods for the experimental determination of the apparent permeability of small-molecule ligands of epigenetic targets.
From 2016 to 2018 he received a research grant from the Department of Pharmacy, University of Salerno, studying the development of small-molecule modulators of Arginine Methyltransferase (PRMT).
From December 2018 to December 2021 he is Researcher at the Department of Pharmacy, University of Salerno.
Since December 2021 he is Associate Professor at the Department of Pharmacy, University of Salerno.
Research activity
Design, synthesis and study of the biological activity of "epi-drugs" for various epigenetic enzymes (with particular reference to methyltransferases and to acetyltransferases) and for epigenetic reader domains of proteins (mainly bromodomains).
Design, synthesis and study of the biological activity of drugs active on the nervous system (with particular reference to the modulators of the Translocator 18 kDa Protein (TSPO)).
Development of new strategies for the synthesis of heterocyclic compounds, either through traditional batch synthesis or using the most innovative and advanced techniques (microwaves, solid phase synthesis, flow synthesis).
Application of the most recent biophysical and biomolecular techniques (with particular reference to Surface Plasmonic Resonance (SPR), Microscale Thermophoresis (MST), Differential Scanning Fluorimetry (DSF) and to luminescence-based methods such as AlphaLISA, AlphaScreen, FRET, TR-FRET) for the study of ligand-protein interactions.
Teaching activity
Toxicology Chemistry
Analisys of Drugs 2
