TOXICOLOGY CHEMISTRY

Ciro MILITE TOXICOLOGY CHEMISTRY

0760100038
DIPARTIMENTO DI FARMACIA
EQF7
PHARMACY
2022/2023

YEAR OF COURSE 5
YEAR OF DIDACTIC SYSTEM 2016
AUTUMN SEMESTER
CFUHOURSACTIVITY
540LESSONS
Objectives
THE COURSE IS AIMED AT ACQUIRING KNOWLEDGE AND UNDERSTANDING OF THE CHEMICAL AND TOXICOLOGICAL ASPECTS OF THE MAIN TOSSICOMANOGENE DRUGS AND MAJOR METALS RESPONSIBLE FOR POISONING.
THE STUDENT APPLYING THE ACQUIRED SKILLS TO BE ABLE TO ASSESS THE LEVEL OF TOXICITY AND THE RISKS OF THE SUBSTANCES OBJECT OF THE COURSE.
Prerequisites
IN ADDITION TO ALL THE COURSES OF THE 2ND
YEAR, IT IS ALSO REQUIRED TO KNOW THE BASICS
OF MEDICINAL CHEMISTRY I AND II
Contents
- TOXICOLOGY AND TOXICOLOGICAL CHEMISTRY (2 HOURS- 0.25 ECTS)
- KINDS OF TOXIC SUBSTANCES (2 HOURS- 0.25 ECTS)
- EXPOSURE TO TOXIC SUBSTANCES (2 HOURS- 0.25 ECTS)
- DOSE–RESPONSE RELATIONSHIPS AND RELATIVE TOXICITIES (2 HOURS- 0.25 ECTS)
- KINETIC AND NONKINETIC TOXICOLOGY (2 HOURS- 0.25 ECTS)
- PHASES OF TOXICITY (2 HOURS- 0.25 ECTS)
- CHEMICAL NATURE OF TOXICANTS (2 HOURS- 0.25 ECTS)
- BIOCHEMICAL TRANSFORMATIONS (2 HOURS- 0.25 ECTS)
- PHASE I AND PHASE II METABOLIC REACTIONS OF XENOBIOTIC COMPOUNDS (4 HOURS- 0.50 ECTS)
- BIOCHEMICAL MECHANISMS OF TOXICITY (2 HOURS- 0.25 ECTS)
- CARCINOGENESIS AND MUTAGENESIS (2 HOURS- 0.25 ECTS)
- TOXIC SUBSTANCES (ELEMENTS (2 HOURS- 0.25 ECTS), INORGANIC COMPOUNDS (2 HOURS- 0.25 ECTS), ORGANIC COMPOUNDS (2 HOURS- 0.25 ECTS), ORGANOMETALLICS, NATURAL PRODUCTS (2 HOURS- 0.25 ECTS), DRUGS OF ABUSE (4 HOURS- 0.50 ECTS)
- ENVIRONMENTAL BIOLOGICAL PROCESSES AND ECOTOXICOLOGY (2 HOURS- 0.25 ECTS)
- ANALYSIS OF XENOBIOTICS (2 HOURS- 0.25 ECTS)
Teaching Methods
THE COURSE WILL INCLUDE LECTURES AND IN-CLASS DISCUSSIONS OF PRIMARY LITERATURE FOR A TOTAL OF 40 HOURS (5 CFU = 5 ECTS).
Verification of learning
THE FINAL ORAL EXAMINATION, ABOUT 30 MINUTES, WILL CONSIST OF IN-DEPTH QUESTIONS AND DISCUSSION OF THE TOPICS COVERED DURING THE COURSE. TO PASS THE EXAMINATION, THE STUDENT SHOULD OBTAIN A SCORE OF AT LEAST 18/30.
Texts
MARZANO E MEDANA - CHIMICA TOSSICOLOGICA - 2018 - PICCIN

S.E. MANAHAN, TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY, 3RDED., CRC PRESS

CASARETT& DOULL, ELEMENTI DI TOSSICOLOGIA, CURTIS D. KLASSEN, JOHN B. WATKINS, CASA EDITRICE AMBROSIANA
More Information
THE COURSE WILL BE TAUGHT IN ITALIAN.
ATTENDANCE IS HIGLY RECOMMENDED.
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