Alessia BERTAMINO | MEDICINAL CHEMISTRY II
Alessia BERTAMINO MEDICINAL CHEMISTRY II
cod. 0760300022
MEDICINAL CHEMISTRY II
| 0760300022 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF7 | |
| PHARMACY | |
| 2024/2025 |
| OBBLIGATORIO | |
| YEAR OF COURSE 4 | |
| YEAR OF DIDACTIC SYSTEM 2023 | |
| AUTUMN SEMESTER |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| CHIM/08 | 6 | 48 | LESSONS |
| Exam | Date | Session | |
|---|---|---|---|
| GENNAIO | 05/02/2025 | SESSIONE ORDINARIA | |
| GENNAIO | 05/02/2025 | SESSIONE DI RECUPERO |
| Objectives | |
|---|---|
| THIS COURSE IS FOCUSED ON THE KNOWLEDGES ACQUISITION AND COMPREHENSION OF THE DIFFERENT SYNTHETIC PHASES, CHEMICAL-PHYSICAL PROPERTIES AND STRUCTURE-ACTIVITY RELATIONSHIP FOR DRUGS ACTING AS ION CHANNEL MODULATORS, ENZYMATIC INHIBITORS AND OPIOID DRUGS. AT THE END OF THE COURSE THE STUDENT WILL KNOW: CHEMICAL STRUCTURE, SYNTHESIS, PHYSICAL-CHEMICAL PROPERTIES, STRUCTURE-ACTIVITY RELATIONSHIP, THERAPEUTICS EMPLOYMENT AND SIDE EFFECT OF TREATED DRUGS. THE STUDENT, BY APPLYING THE ACQUIRED KNOWLEDGE SHOULD BE ABLE TO: INTERPRETATE AND ANALYSE THE STRUCTURE OF TREATED DRUGS AND THEIR ACTIVITY AND THE STAGES THAT GOVERN THE MEDICINAL CHEMISTRY RESEARCH, FROM LEAD COMPOUND DISCOVERY TO ITS COMMERCIALIZATION. |
| Prerequisites | |
|---|---|
| STUDENTS SHOULD HAVE KNOWLEDGES ABOUT MEDICINAL CHEMISTRY I. |
| Contents | |
|---|---|
| DESCRIPTION OF THE STRUCTURE AND FUNCTIONALITY OF THE MAIN CLASSES OF RECEPTORS (6H). DISCOVERY, DESIGN AND DEVELOPMENT, STUDY OF THE RELATIONSHIPS, STRUCTURE, ACTIVITY AND MECHANISM OF ACTION AT THE MOLECULAR LEVEL OF THE FOLLOWING CLASSES OF DRUG: SEDATIVES-ANXIOLYTICS-HYPNOTICS (6 H), LOCAL ANESTHETICS (2 H), ANTIARRHYTHMICS (2 H), ANTIEPILEPTICS (2 H), CARDIOTONICS (2 H), ANTIANGINOSIS (2 H), DRUGS ACTIVE ON THE RENIN-ANGIOTENSIN SYSTEM (4H), ANTI-HYPERTENSIVES (2 H), DIURECTIC (2H) NON-STEROID ANTI-INFLAMATORS (NSAIDS) (4 H), ANTI-INFLAMMATORY STEROIDS (FAS) (2 H), IMMUNOMODULATORS (4H), ANTIDIABETICS (2H). SYNTHESIS OF THE MAIN CLASSES OF DRUG TREATED (6 H). |
| Teaching Methods | |
|---|---|
| 48 HOURS (6 CFU) OF CLASSROOM LESSONS ARE PROVIDED ON ALL THE SUBJECTS OF THE COURSE. |
| Verification of learning | |
|---|---|
| ACHIEVEMENT OF THE OBJECTIVES IS CERTIFIED BY PASSING AN EXAM.THE EXAM PROVIDES FOR A PRELIMINARY WRITTEN EXAM TO AN ORAL EXAM THAT TAKES PLACE ON DIFFERENT CALENDARED DAYS. THE WRITTEN TEST CONSISTS OF FIVE ANSWER AND IT HAS A DURATION NOT EXCEEDING 150 MINUTES AND IS AIMED AT VERIFYING THE ABILITY TO PROPERLY APPLY THEORETICAL KNOWLEDGE AND THE ABILITY TO COMMUNICATE IN WRITING. THE ORAL TEST CONSISTS OF A 25 MINUTE DISCUSSION AIMED AT ASSESSING THE LEVEL OF KNOWLEDGE AND UNDERSTANDING ACQUIRED BY THE STUDENT ON THE THEORETICAL CONTENTS OF THE PROGRAM. THE ORAL TEST WILL ALSO ALLOW STUDENTS TO COMMUNICATE WITH THE LANGUAGE SKILLS AND AUTONOMOUS EXPOSURE ORGANIZATION ON THE SAME SUBJECTS TREATED IN THE WRITTEN TEST. The final assessment will not be based solely on the calculation of the arithmetic mean of the scores obtained in the individual tests , but will take into account the assessments obtained in each test independently. A qualitative evaluation of the student’s overall performance will be carried out, taking into account various aspects such as the demonstrated knowledge, the quality of the work performed, problem-solving skills and other relevant elements. |
| Texts | |
|---|---|
| D.A. WILLIAMS, T.L. LEMKE, FOYE’S PRINCIPI DI CHIMICA FARMACEUTICA, PICCIN. • G.L. PATRICK, INTRODUZIONE ALLA CHIMICA FARMACEUTICA, EDISES, II EDIZIONE • WILSON&GISVOLD CHIMICA FARMACEUTICA .ED.CEA • T. NOGRADY, D. WEAVER, MEDICINAL CHEMISTRY – A MOLECULAR AND BIOCHEMICAL APPROACH, 3RD ED., OXFORD UNIVERSITY PRESS. • MONOGRAFIE DELLA COLLANA "CHIMICA DEI RECETTORI", EDITORE C. MELCHIORRE, CLUEB (BOLOGNA). • C. WERMUTH, LE APPLICAZIONI DELLA CHIMICA FARMACEUTICA, EDISES. • P. KROGSGAARD-LARSEN, T. LILJEFORS, U. MADSEN ED., TEXTBOOK OF DRUG DESIGN AND DISCOVERY, TAYLOR & FRANCIS. • GOODMAN & GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, TWELFTH EDITION, MCGRAW-HILL MEDICAL PUBLISHING DIVISION (2011). • WILSON AND GISVOLD'S TEXTBOOK OF ORGANIC MEDICINAL AND PHARMACEUTICAL CHEMISTRY-LIPPINCOTT WILLIAMS & WILKINS • KLEEMANN, ENGEL, KUTSCHER, REICHERT, PHARMACEUTICAL SUBSTANCES, 5TH ED., THIEME VERLAG. • BURGER’S MEDICINAL CHEMISTRY, DRUG DISCOVERY AND DEVELOPMENT. 7TH EDITION. WILEY. JOURNAL OF MEDICINAL CHEMISTRY, ACS. |
| More Information | |
|---|---|
| THE COURSE IS TAUGHT IN ITALIAN THE ATTENDANCE IS MANDATORY LOCATION: DEPARTMENT OF PHARMACY |
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