Alessia BERTAMINO | MEDICINAL CHEMISTRY III
Alessia BERTAMINO MEDICINAL CHEMISTRY III
cod. 0760300029
MEDICINAL CHEMISTRY III
| 0760300029 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF7 | |
| PHARMACY | |
| 2024/2025 |
| OBBLIGATORIO | |
| YEAR OF COURSE 5 | |
| YEAR OF DIDACTIC SYSTEM 2023 | |
| AUTUMN SEMESTER |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| CHIM/08 | 6 | 48 | LESSONS |
| Exam | Date | Session | |
|---|---|---|---|
| GENNAIO | 05/02/2025 | SESSIONE ORDINARIA | |
| GENNAIO | 05/02/2025 | SESSIONE DI RECUPERO |
| Objectives | |
|---|---|
| The aim of the course is to provide basic knowledge about general strategies of design, synthesis, the study of the mechanism and chemical-toxicological aspects and the relationship between chemical structure and biological activity of drugs that act on the main transmission systems. Students will acquire knowledge about chemical structure, synthesis, chemical-physical properties, and structure-activity relationship of discussed drugs and their mechanism and side effects. Students will apply the acquired skills to interpretate and analyze the structure of the drugs and their pharmacological activities, and to understand phases that govern the research in chemical-pharmaceutical field from the discovery of lead compound to the commercialization. |
| Prerequisites | |
|---|---|
| STUDENTS SHOULD HAVE KNOWLEDGES ABOUT ORGANIC AND INORGANIC CHEMISTRY, BIOLOGY, BIOCHEMISTRY, ELEMENTS OF ANATOMY AND PHYSIOLOGY. TO PASS MEDICINAL CHEMISTRY I AND II IS MANDATORY. |
| Contents | |
|---|---|
| DESCRIPTON OF STRUCTURE AND FUNCTIONALITY OF THE NEUROTRANSMITTERS INVOLVED IN THE CENTRAL SYSTEM MODULATION (6H). DISCOVERY, DESIGN AND DEVELOPMENT, STUDY OF STRUCTURE-ACTIVITY RELATIONSHIPS AND MECHANISMS OF ACTION AT THE MOLECULAR LEVEL OF THE FOLLOWING DRUG CLASSES: OPIOID DRUGS (6H), ADRENERGIC DRUGS (6 H), COLINERGIC DRUGS (4 H), ANTIHYSTAMINERGIC DRUGS (4 H), DOPAMINERGIC DRUGS (4H), SEROTONINERGIC DRUGS (4H), CNS STIMULATING (2H), ANTILYPIDEMIC DRUGS (2H), GENERAL ANESTETIC (2H), ANTI-ALZHEIMER DRUGS (2 H), SYNTHESIS OF THE MAIN DRUGS TREATED (6 H). |
| Teaching Methods | |
|---|---|
| 48 HOURS (6 CFU) OF CLASSROOM LESSONS ARE PROVIDED ON ALL THE SUBJECTS OF THE COURSE. |
| Verification of learning | |
|---|---|
| ACHIEVEMENT OF THE OBJECTIVES IS CERTIFIED BY PASSING AN EXAM.THE EXAM PROVIDES FOR A PRELIMINARY WRITTEN EXAM TO AN ORAL EXAM THAT TAKES PLACE ON DIFFERENT CALENDARED DAYS. THE WRITTEN TEST CONSISTS OF FIVE ANSWER AND IT HAS A DURATION NOT EXCEEDING 150 MINUTES AND IS AIMED AT VERIFYING THE ABILITY TO PROPERLY APPLY THEORETICAL KNOWLEDGE AND THE ABILITY TO COMMUNICATE IN WRITING. THE ORAL TEST CONSISTS OF A 25 MINUTE DISCUSSION AIMED AT ASSESSING THE LEVEL OF KNOWLEDGE AND UNDERSTANDING ACQUIRED BY THE STUDENT ON THE THEORETICAL CONTENTS OF THE PROGRAM. THE ORAL TEST WILL ALSO ALLOW STUDENTS TO COMMUNICATE WITH THE LANGUAGE SKILLS AND AUTONOMOUS EXPOSURE ORGANIZATION ON THE SAME SUBJECTS TREATED IN THE WRITTEN TEST. THE FINAL ASSESSMENT WILL NOT BE BASED SOLELY ON THE CALCULATION OF THE ARITHMETIC MEAN OF THE SCORES OBTAINED IN THE INDIVIDUAL TESTS , BUT WILL TAKE INTO ACCOUNT THE ASSESSMENTS OBTAINED IN EACH TEST INDEPENDENTLY. A QUALITATIVE EVALUATION OF THE STUDENT’S OVERALL PERFORMANCE WILL BE CARRIED OUT, TAKING INTO ACCOUNT VARIOUS ASPECTS SUCH AS THE DEMONSTRATED KNOWLEDGE, THE QUALITY OF THE WORK PERFORMED, PROBLEM-SOLVING SKILLS AND OTHER RELEVANT ELEMENTS. |
| Texts | |
|---|---|
| D.A. WILLIAMS, T.L. LEMKE, FOYE’S PRINCIPI DI CHIMICA FARMACEUTICA, PICCIN. • G.L. PATRICK, INTRODUZIONE ALLA CHIMICA FARMACEUTICA, EDISES, II EDIZIONE • WILSON&GISVOLD CHIMICA FARMACEUTICA .ED.CEA • T. NOGRADY, D. WEAVER, MEDICINAL CHEMISTRY – A MOLECULAR AND BIOCHEMICAL APPROACH, 3RD ED., OXFORD UNIVERSITY PRESS. • MONOGRAFIE DELLA COLLANA "CHIMICA DEI RECETTORI", EDITORE C. MELCHIORRE, CLUEB (BOLOGNA). • C. WERMUTH, LE APPLICAZIONI DELLA CHIMICA FARMACEUTICA, EDISES. • P. KROGSGAARD-LARSEN, T. LILJEFORS, U. MADSEN ED., TEXTBOOK OF DRUG DESIGN AND DISCOVERY, TAYLOR & FRANCIS. • GOODMAN & GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, TWELFTH EDITION, MCGRAW-HILL MEDICAL PUBLISHING DIVISION (2011). • WILSON AND GISVOLD'S TEXTBOOK OF ORGANIC MEDICINAL AND PHARMACEUTICAL CHEMISTRY-LIPPINCOTT WILLIAMS & WILKINS • KLEEMANN, ENGEL, KUTSCHER, REICHERT, PHARMACEUTICAL SUBSTANCES, 5TH ED., THIEME VERLAG. • BURGER’S MEDICINAL CHEMISTRY, DRUG DISCOVERY AND DEVELOPMENT. 7TH EDITION. WILEY. JOURNAL OF MEDICINAL CHEMISTRY, ACS. |
| More Information | |
|---|---|
| THE COURSE IS TAUGHT IN ITALIAN THE ATTENDANCE IS MANDATORY LOCATION: DEPARTMENT OF PHARMACY |
BETA VERSION Data source ESSE3 [Ultima Sincronizzazione: 2025-01-16]
