VINCENZO VESTUTO | Curriculum
VINCENZO VESTUTO Curriculum
EDUCATION AND TRAINING
- PhD in Pharmaceutical Sciences (XXXIV cycle) obtained on 22/04/2022 at the Department of Pharmacy, University of Salerno, with a grade of excellent. Thesis entitled: “Design and synthesis of new small molecules as ion channel modulators” Tutor: prof. Alessia Bertamimo, Co-tutor: prof. Pietro Campiglia.
- Practice ability to profession of Pharmacy, obtained in the 2nd session of 2017 at the Department of Pharmacy, University of Salerno.
- Master's degree in Medicinal Chemistry obtained on 30/10/2017 at the Department of Pharmacy, University of Salerno, with a grade of 110/110 summa cum laude. Thesis entitled: “Synthesis of new polycyclic indoles from tetrahydrobetacarbolines.” Supervisor: prof. Alessia Bertamino.
ACADEMIC POSITIONS AND RESEARCH EXPERIENCES
- 01/05/2023-current: assistant professor of biochemistry at the Department of Pharmacy, University of Salerno.
- 01/11/2018-31/01/2023: research fellow at the Department of Pharmacy, University of Salerno to carry out projects related to the development and evaluation of the biological activity of new modulators of ion channels (TRPM8 and Kv7), viral targets (MPro, PlPro, S protein, cathepsins), cannabinoids (CB2), inflammation (5-LOX, sEH), cancer (kinases, GLS-1, CXCR4, ABC transporters). Scientific Responsibles: prof. Pietro Campiglia, prof. Alessia Bertamino.
- 30/10/2017-31/01/2019: volunteer research activity at the Department of Pharmacy, University of Salerno, dealing mainly with the synthesis of pharmacologically active molecules aimed at the treatment of cancer and channelopathies. Scientific Responsible: prof. Pietro Campiglia.
RESEARCH ACTIVITY
Lines of research are mainly focused in 4 areas:
1) In vitro and in vivo characterization of the antitumor and neuroprotective mechanism of synthetic compounds toward emerging targets.
2) Study of the bioactivity of novel Mediterranean nutraceuticals and natural complex matrices to be used both as possible protectors in different models of diseases associated with oxidative stress and endoplasmic reticulum stress (neurodegenerative diseases, NAFLD, photooxidative damage, and intestinal inflammation) and for the development of strategies to potentiate anticancer chemotherapy.
3) High-throughput screening assays using modern biochemical and biophysical techniques for the assessment of binding and modulation of enzyme and ion activity by small molecules, peptides and peptidomimetics.
4) Analysis of the functional role of TRPM8 protein in unfolded protein response.
ACADEMIC TEACHING ACTIVITY
