Sonia PIACENTE | PHARMACOGNOSY AND PHYTOCHEMISTRY

cod. 0712100014

PHARMACOGNOSY AND PHYTOCHEMISTRY

	0712100014
	DIPARTIMENTO DI FARMACIA
	EQF6
	HERBAL SCIENCE
	2018/2019

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 2
	YEAR OF DIDACTIC SYSTEM 2016
	SECONDO SEMESTRE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	FARMACOGNOSIA MODULO DI FARMACOGNOSIA E FITOCHIMICA
	BIO/15	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
2	FITOCHIMICA MODULO DI FARMACOGNOSIA E FITOCHIMICA
	BIO/15	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	SONIA PIACENTE1 T Curriculum
	MILENA MASULLO2 Curriculum

	Objectives
	Acquisition of knowledge on the plant origin, morphology, chemical composition, biological activity and use of herbal drugs and derived preparations. The student, on the basis of the acquired skills, will be able toelaborate criteria to recognize and use the herbal drugs. Acquision of knowledge on plant metabolism, with particular attention to plant secondary metabolites. The student, on the basis of the acquired skills, will be able to understand and correlate the main classes of natural products.

Acquisition of knowledge on the plant origin, morphology, chemical composition, biological activity and use of herbal drugs and derived preparations. The student, on the basis of the acquired skills, will be able toelaborate criteria to recognize and use the herbal drugs.
Acquision of knowledge on plant metabolism, with particular attention to plant secondary metabolites. The student, on the basis of the acquired skills, will be able to understand and correlate the main classes of natural products.

	Prerequisites
	PLANT BIOLOGY, PHARMACEUTICAL BOTANY,ORGANIC CHEMISTRY, AND BIOCHEMISTRY

	Contents
	DEFINITION OF PHARMACOGNOSY, HERBAL DRUG AND ACTIVE PRINCIPLE; PLANT NOMENCLATURE AND TAXONOMY. ORGANIZED AND NOT ORGANIZED HERBAL DRUGS. EXTRACTIVE METHODS. CONSERVATION, STABILITY AND VARIABILITY OF HERBAL DRUGS AND DERIVED PREPARATIONS. ELEMENTS OF QUALITY CONTROL. FOR EACH HERBAL DRUG: BOTANICAL SOURCE, MACROSCOPIC AND MICROSCOPIC CHARACTERS, QUALI-QUANTITATIVE CHEMICAL PROFILE, BIOACTIVE CONSTITUENTS, BIOLOGICAL ACTIVITY, THERAPEUTIC USES. HERBAL DRUGS EMPLOYED FOR THEIR CONTENT IN CARBOHYDRATES, TERPENOIDS AND STEROIDS; ESSENTIAL OILS; RESINS AND GUMS, SAPONINS, CARDIAC GLYCOSIDES; AROMATIC COMPOUNDS, PHENOLS, TANNINS, FLAVONOIDS, COUMARINS, LIGNANS. ANTRAQUINONES. DRUGS EMPLOYED FOR THEIR CONTENT IN ALKALOIDS. PHYTOCHEMISTRY BASIC PRINCIPLES OF THE PRIMARY METABOLISM AND THE MAIN PATHWAYS OF SECONDARY METABOLISM. DEFINITION AND SYSTEMATICS OF SECONDARY METABOLITES (MS). METHODOLOGIES APPLIED TO STUDY THE SECONDARY METABOLITES PATHWAY. BIOSYNTHETIC PATHWAY OF CARBOHYDRATES: MONOSACCARIDES, DISACCHARIDES, POLISACCHARIDES, STARCH. BIOSYNTHETIC PATHWAY OF SHIKIMATE. (PHENOLS, POLYPHENOLS, COUMARINS, PHENYLPROPANOIDS). BIOSYNTHETIC PATHWAY OF ACETATE. POLYKETIDES AND FLAVONOIDS. BIOSYNTHETIC PATHWAY OF MEVALONATE. THE ROLE OF TERPENOIDS IN PLANT DEFENSE. TERPENOIDS: LOCALIZATION, BIOLOGICAL ACTIVITY. STRUCTURAL FEATURES OF MONOTERPENES, SESQUITERPENES, DITERPENES, TRITERPENES, STEROLS, STEROIDAL AND TRITERPENOID SAPONINS. BASIC PRINCIPLES OF THE ALKALOIDS BIOSYNTHESIS: ALKALOIDS DERIVING FROM ORNITHINE, LISINE, PHENYLALANINE, TYROSINE, AND TRYPTOPHAN.

Contents

DEFINITION OF PHARMACOGNOSY, HERBAL DRUG AND ACTIVE PRINCIPLE; PLANT NOMENCLATURE AND TAXONOMY. ORGANIZED AND NOT ORGANIZED HERBAL DRUGS. EXTRACTIVE METHODS. CONSERVATION, STABILITY AND VARIABILITY OF HERBAL DRUGS AND DERIVED PREPARATIONS. ELEMENTS OF QUALITY CONTROL. FOR EACH HERBAL DRUG: BOTANICAL SOURCE, MACROSCOPIC AND MICROSCOPIC CHARACTERS, QUALI-QUANTITATIVE CHEMICAL PROFILE, BIOACTIVE CONSTITUENTS, BIOLOGICAL ACTIVITY, THERAPEUTIC USES. HERBAL DRUGS EMPLOYED FOR THEIR CONTENT IN CARBOHYDRATES, TERPENOIDS AND STEROIDS; ESSENTIAL OILS; RESINS AND GUMS, SAPONINS, CARDIAC GLYCOSIDES; AROMATIC COMPOUNDS, PHENOLS, TANNINS, FLAVONOIDS, COUMARINS, LIGNANS. ANTRAQUINONES. DRUGS EMPLOYED FOR THEIR CONTENT IN ALKALOIDS.
PHYTOCHEMISTRY
BASIC PRINCIPLES OF THE PRIMARY METABOLISM AND THE MAIN PATHWAYS OF SECONDARY METABOLISM. DEFINITION AND SYSTEMATICS OF SECONDARY METABOLITES (MS). METHODOLOGIES APPLIED TO STUDY THE SECONDARY METABOLITES PATHWAY. BIOSYNTHETIC PATHWAY OF CARBOHYDRATES: MONOSACCARIDES, DISACCHARIDES, POLISACCHARIDES, STARCH. BIOSYNTHETIC PATHWAY OF SHIKIMATE. (PHENOLS, POLYPHENOLS, COUMARINS, PHENYLPROPANOIDS). BIOSYNTHETIC PATHWAY OF ACETATE. POLYKETIDES AND FLAVONOIDS. BIOSYNTHETIC PATHWAY OF MEVALONATE. THE ROLE OF TERPENOIDS IN PLANT DEFENSE. TERPENOIDS: LOCALIZATION, BIOLOGICAL ACTIVITY. STRUCTURAL FEATURES OF MONOTERPENES, SESQUITERPENES, DITERPENES, TRITERPENES, STEROLS, STEROIDAL AND TRITERPENOID SAPONINS. BASIC PRINCIPLES OF THE ALKALOIDS BIOSYNTHESIS: ALKALOIDS DERIVING FROM ORNITHINE, LISINE, PHENYLALANINE, TYROSINE, AND TRYPTOPHAN.

	Teaching Methods
	LECTURES, SEMINARS, TUTORIALS

	Verification of learning
	THE EXAMINATION CONSISTS OF A WRITTEN AND ORAL TEST, TO BE SUSTEINED IN THE SAME EXAM SESSION. THE RATING IS X/30. PASS THE WRITTEN TEST WITH A SCORE OF 18/30, IT IS MANDATORY TO BE ABLE TO TAKE THE ORAL TEST, AND REACH THE FINAL GRADE. THE WRITTEN TEST TAKES TWO HOURS AND CONSISTS OF OPEN QUESTIONS ON THE MAIN LEARNING OUTCOMES OF PHARMACOGNOSY AND PHYTOCHEMISTRY. THE STUDENT WILL BE ASKED TO DISCUSS THE MAIN TOPICS OF THE COURSE, TRYING TO DEMONSTRATE CRITICAL THOUGHT AND AWARENESS OF THE SUBJECTS OF THE FIELD OF STUDY.

Verification of learning

THE EXAMINATION CONSISTS OF A WRITTEN AND ORAL TEST, TO BE SUSTEINED IN THE SAME EXAM SESSION. THE RATING IS X/30. PASS THE WRITTEN TEST WITH A SCORE OF 18/30, IT IS MANDATORY TO BE ABLE TO TAKE THE ORAL TEST, AND REACH THE FINAL GRADE. THE WRITTEN TEST TAKES TWO HOURS AND CONSISTS OF OPEN QUESTIONS ON THE MAIN LEARNING OUTCOMES OF PHARMACOGNOSY AND PHYTOCHEMISTRY.
THE STUDENT WILL BE ASKED TO DISCUSS THE MAIN TOPICS OF THE COURSE, TRYING TO DEMONSTRATE CRITICAL THOUGHT AND AWARENESS OF THE SUBJECTS OF THE FIELD OF STUDY.

	Texts
	DEWICK PAUL M., CHIMICA, BIOSINTESI E BIOATTIVITÀ DELLE SOSTANZE NATURALI 2/ED.- EDIZIONE ITALIANA A CURA DI ERNESTO FATTORUSSO [DEWICK - PICCIN EDITORE] MANN J. CHEMICAL ASPECTS OF BIOSYNTHESIS, CHEMISTRY PRIMERS, OXFORD. G. SAMUELSSON FARMACOGNOSIA - FARMACI DI ORIGINE NATURALE. SECONDA EDIZIONE ITALIANA A CURA DI: F. CAPASSO, R. DE PASQUALE, I. MORELLI, CASA EDITRICE EMSI, ROMA. F. CAPASSO, R. DE PASQUALE, G. GRANDOLINI, N. MASCOLO. FARMACOGNOSIA: FARMACI NATURALI, LORO PREPARAZIONI ED IMPIEGO TERAPEUTICO, CASA EDITRICE: SPRINGER-VERLAG

Texts

DEWICK PAUL M., CHIMICA, BIOSINTESI E BIOATTIVITÀ DELLE SOSTANZE NATURALI 2/ED.- EDIZIONE ITALIANA A CURA DI ERNESTO FATTORUSSO [DEWICK - PICCIN EDITORE]
MANN J. CHEMICAL ASPECTS OF BIOSYNTHESIS, CHEMISTRY PRIMERS, OXFORD.
G. SAMUELSSON FARMACOGNOSIA - FARMACI DI ORIGINE NATURALE. SECONDA EDIZIONE ITALIANA A CURA DI: F. CAPASSO, R. DE PASQUALE, I. MORELLI, CASA EDITRICE EMSI, ROMA.
F. CAPASSO, R. DE PASQUALE, G. GRANDOLINI, N. MASCOLO.
FARMACOGNOSIA: FARMACI NATURALI, LORO PREPARAZIONI ED IMPIEGO TERAPEUTICO, CASA EDITRICE: SPRINGER-VERLAG

	More Information
	SONIA PIACENTE HTTP://WWW.UNISA.IT/DOCENTI/SONIAPIACENTE/INDEX MILENA MASULLO HTTP://WWW.UNISA.IT/DOCENTI/MILENAMASULLO/INDEX

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Sonia PIACENTE | PHARMACOGNOSY AND PHYTOCHEMISTRY