Christophe DANIEL | BIOMATERIALS

cod. 0522300058

BIOMATERIALS

	0522300058
	DEPARTMENT OF CHEMISTRY AND BIOLOGY "ADOLFO ZAMBELLI"
	EQF7
	CHEMISTRY
	2019/2020

CURRICULUM BIOMOLECULAR CHEMISTRY

	OBBLIGATORIO
	YEAR OF COURSE 1
	YEAR OF DIDACTIC SYSTEM 2016
	ANNUALE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
	CHIM/04	12	96	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	CHRISTOPHE DANIEL T Curriculum
	PAOLA RIZZO Curriculum

	Objectives
	MODULE 1 BIOMATERIALS: CHEMICAL STRUCTURES AND PHYSICAL PROPERTIES THE COURSE AIMS TO DESCRIBE THE STRUCTURAL CHARACTERISTICS OF BIOMATERIALS AND THEIR PHYSICAL PROPERTIES. IN DETAIL THE CRYSTAL STRUCTURES OF METALS, ALLOYS, CERAMIC MATERIALS, COMPOSITE MATERIALS AND POLYMERIC MATERIALS WILL BE DESCRIBED. THE IMPERFECTIONS PRESENT IN THE SOLIDS, PUNCTUAL DEFECTS AND DISLOCATIONS WILL BE DESCRIBED, HIGHLIGHTING HOW THEIR PRESENCE ALTERS THE PROPERTIES OF THE MATERIALS THEMSELVES, FOR EXAMPLE INCREASING THEIR RESISTANCE. THE MAIN TECHNIQUES OF CHARACTERIZATION OF THE MATERIALS WILL BE BRIEFLY INTRODUCED AND IN PARTICULAR THE TECHNIQUES FOR THE DETERMINATION OF THE CRYSTALLINE STRUCTURES OF SOLIDS AND THE MICROSCOPIC ONES AIMED FOR EXAMPLE AT THE DETERMINATION OF GRAIN SIZES WILL BE BRIEFLY DESCRIBED. PARTICULAR ATTENTION WILL BE PAID TO DESCRIBING HOW THE TRANSFORMATION OF THE MICROSTRUCTURE MODIFIES THE PROPERTIES OF THE MATERIALS THEMSELVES SUCH AS FOR EXAMPLE THE THERMAL PROPERTIES (THERMAL CAPACITY, THERMAL EXPANSION, THERMAL CONDUCTIVITY) AND OPTICAL PROPERTIES. THE MAIN SKILLS DEVELOPED BY THE STUDENT WILL BE: THE ABILITY TO KNOW THE STRUCTURAL CHARACTERISTICS AND PROPERTIES OF THE DIFFERENT MATERIALS. MODULE 2 BIOMATERIALS:MEDICAL DEVICES AND INTERACTION WITH BIOLOGICAL SYSTEMS THE MAIN KNOWLEDGE ACQUIRED BY THE STUDENT WILL CONCERN: THE AIM OF THE COURSE IS TO DESCRIBE THE MOST WIDESPREAD AND USED MATERIALS FOR BIOMEDICAL APPLICATIONS. IN THE FIRST PART OF THE COURSE THE CHEMICAL AND PHYSICAL PROPERTIES INVOLVED IN THE INTERACTION WITH THE BIOLOGICAL SYSTEMS OF THESE MATERIALS WILL BE DESCRIBED. SUBSEQUENTLY, THE CLASSES OF MATERIALS USED IN MEDICINE (CERAMICS, METALS, POLYMERS, COMPOSITES) IN THEIR MOST WIDESPREAD APPLICATIONS WILL ALSO BE DESCRIBED. THE MOST IMPORTANT THERAPEUTIC DEVICES (ARTICULATION AND DENTAL PROSTHESES, CARDIOVASCULAR DEVICES, CATHETERS, DEVICES FOR OPHTHALMOLOGY, NEPHROLOGY, APPLICATIONS FOR CONTROLLED DRUG RELEASE, ETC.) AND THE PROBLEMS ASSOCIATED WITH IMPLANTATION (RESPONSE OF THE IMMUNE SYSTEM, INFECTIONS, TECHNIQUES OF STERILIZATION, ETC.) TOGETHER WITH THEIR POSSIBLE SOLUTIONS, WILL ALSO BE DESCRIBED. THE MAIN SKILLS DEVELOPED BY THE STUDENT WILL BE: THE COURSE AIMS TO PROVIDE STUDENTS WITH THE ABILITY TO DISCUSS AND ANALYZE PROBLEMS RELATED TO THE INTERACTION BETWEEN MATERIALS AND BIOLOGICAL SYSTEMS AND AT THE SAME TIME TO RECOGNIZE THE APPLICATIVE POTENTIAL OF A MATERIAL IN THE BIOMEDICAL FIELD

MODULE 1
BIOMATERIALS: CHEMICAL STRUCTURES AND PHYSICAL PROPERTIES
THE COURSE AIMS TO DESCRIBE THE STRUCTURAL CHARACTERISTICS OF BIOMATERIALS AND THEIR PHYSICAL PROPERTIES.
IN DETAIL THE CRYSTAL STRUCTURES OF METALS, ALLOYS, CERAMIC MATERIALS, COMPOSITE MATERIALS AND POLYMERIC MATERIALS WILL BE DESCRIBED.
THE IMPERFECTIONS PRESENT IN THE SOLIDS, PUNCTUAL DEFECTS AND DISLOCATIONS WILL BE DESCRIBED, HIGHLIGHTING HOW THEIR PRESENCE ALTERS THE PROPERTIES OF THE MATERIALS THEMSELVES, FOR EXAMPLE INCREASING THEIR RESISTANCE.
THE MAIN TECHNIQUES OF CHARACTERIZATION OF THE MATERIALS WILL BE BRIEFLY INTRODUCED AND IN PARTICULAR THE TECHNIQUES FOR THE DETERMINATION OF THE CRYSTALLINE STRUCTURES OF SOLIDS AND THE MICROSCOPIC ONES AIMED FOR EXAMPLE AT THE DETERMINATION OF GRAIN SIZES WILL BE BRIEFLY DESCRIBED.
PARTICULAR ATTENTION WILL BE PAID TO DESCRIBING HOW THE TRANSFORMATION OF THE MICROSTRUCTURE MODIFIES THE PROPERTIES OF THE MATERIALS THEMSELVES SUCH AS FOR EXAMPLE THE THERMAL PROPERTIES (THERMAL CAPACITY, THERMAL EXPANSION, THERMAL CONDUCTIVITY) AND OPTICAL PROPERTIES.
THE MAIN SKILLS DEVELOPED BY THE STUDENT WILL BE:
THE ABILITY TO KNOW THE STRUCTURAL CHARACTERISTICS AND PROPERTIES OF THE DIFFERENT MATERIALS.

MODULE 2
BIOMATERIALS:MEDICAL DEVICES AND INTERACTION WITH BIOLOGICAL SYSTEMS
THE MAIN KNOWLEDGE ACQUIRED BY THE STUDENT WILL CONCERN:
THE AIM OF THE COURSE IS TO DESCRIBE THE MOST WIDESPREAD AND USED MATERIALS FOR BIOMEDICAL APPLICATIONS. IN THE FIRST PART OF THE COURSE THE CHEMICAL AND PHYSICAL PROPERTIES INVOLVED IN THE INTERACTION WITH THE BIOLOGICAL SYSTEMS OF THESE MATERIALS WILL BE DESCRIBED. SUBSEQUENTLY, THE CLASSES OF MATERIALS USED IN MEDICINE (CERAMICS, METALS, POLYMERS, COMPOSITES) IN THEIR MOST WIDESPREAD APPLICATIONS WILL ALSO BE DESCRIBED. THE MOST IMPORTANT THERAPEUTIC DEVICES (ARTICULATION AND DENTAL PROSTHESES, CARDIOVASCULAR DEVICES, CATHETERS, DEVICES FOR OPHTHALMOLOGY, NEPHROLOGY, APPLICATIONS FOR CONTROLLED DRUG RELEASE, ETC.) AND THE PROBLEMS ASSOCIATED WITH IMPLANTATION (RESPONSE OF THE IMMUNE SYSTEM, INFECTIONS, TECHNIQUES OF STERILIZATION, ETC.) TOGETHER WITH THEIR POSSIBLE SOLUTIONS, WILL ALSO BE DESCRIBED.
THE MAIN SKILLS DEVELOPED BY THE STUDENT WILL BE:
THE COURSE AIMS TO PROVIDE STUDENTS WITH THE ABILITY TO DISCUSS AND ANALYZE PROBLEMS RELATED TO THE INTERACTION BETWEEN MATERIALS AND BIOLOGICAL SYSTEMS AND AT THE SAME TIME TO RECOGNIZE THE APPLICATIVE POTENTIAL OF A MATERIAL IN THE BIOMEDICAL FIELD

	Prerequisites
	NECESSARY KNOWLEDGE OF PHYSICS AND CHEMISTRY, AS WELL AS THOSE OF POLYMER CHEMISTRY

	Contents
	1) FIRST MODULE (BIOMATERIALS: CHEMICAL STRUCTURES AND PHYSICAL PROPERTIES; PROF. SS P. RIZZO): STRUCTURAL CHARACTERISTICS OF MATERIALS AND THE RELATIVE PHYSICAL PROPERTIES. CRYSTALLINE STRUCTURES OF METALS, ALLOYS, CERAMIC MATERIALS, COMPOSITE MATERIALS AND POLYMERIC MATERIALS. IMPERFECTIONS PRESENT IN SOLIDS, TIMELY DEFECTS AND DISCOVERY HIGHLIGHTING AS THEIR PRESENCE ALTER THE PROPERTIES OF THE SAME MATERIALS EXTENDING FOR EXAMPLE THE RESISTANCE. MAIN TECHNIQUES OF CHARACTERIZATION OF THE MATERIALS AND IN PARTICULAR THE TECHNIQUES FOR THE DETERMINATION OF THE CRYSTALLINE STRUCTURES OF THE SOLIDS AND THE MICROSCOPIC STRUCTURES, SUCH AS THE DETERMINATION OF GRAIN DIMENSIONS (TEM, SEM), WILL BE DESCRIBED BRIEFLY. TRANSFORMATION OF THE MICROSTRUCTURE AND THEREFORE THE PROPERTIES OF THE MATERIALS HAVE THE SAME AS EXAMPLE THERMAL PROPERTIES (THERMAL CAPACITY, THERMAL EXPANSION, THERMAL CONDUCTIVITY) AND THOSE OPTICS. 2) SECOND MODULE (BIOMATERIALS: MEDICAL DEVICES AND INTERACTION WITH BIOLOGICAL SYSTEMS; PROF. C. DANIEL): BIOMATERIALS AND BIOCOMPATIBILITY, BIO-INERTIA AND BIO-ACTIVITY, DEFINITIONS. (0.5 CFU) INTRODUCTION TO CLASSES OF MATERIALS USED IN MEDICINE (CERAMIC, METALLIC, POLYMERIC, COMPOSITE). (0.5 CFU) THERAPEUTIC ISSUES AND PROBLEMS (ORTHOPEDICS, DENTISTRY, CARDIOVASCULAR DEVICES, CATHETER, OPHTHALMOLOGY, NEFROLOGY, CONTROLLED RELEASE OF DRUGS, ETC.) (0.5 CFU) CERAMIC BIOMATERIALS (PREPARATION TECHNIQUES, PROPERTIES-STRUCTURE RELATIONSHIP, ADVANTAGES AND DISADVANTAGES, APPLICATIONS) (0.5 CFU) METALLIC BIOMATERIALS (METALS AND ALLOYS, PROPERTY-STRUCTURE RELATIONSHIPS, BENEFITS AND FAULTS, APPLICATIONS). (0.5 CFU) POLYMERIC BIOMATERIALS (DEFINITIONS AND CLASSIFICATIONS, SYNTHESIS, SOLID STATE AND PROPERTY-STRUCTURE RELATIONSHIPS, APPLICATIONS FOR POLYMER CLASSES). (1 CFU) COMPOSITE BIOMATERIALS (DEFINITIONS, PREPARATION, PROPERTY-STRUCTURE RELATIONSHIP, APPLICATIONS). (1 CFU) PROBLEMS ASSOCIATED WITH IMPLANTS (INFECTIONS) AND POSSIBLE SOLUTION (STERILIZATION TECHNIQUES). (0.5 CFU) BIOMATERIALS WITH ANTIMICROBIC ACTIVITY. (0.5 CFU) HYDROGELS (DEFINITIONS, PREPARATION, PROPERTY-STRUCTURE RELATIONSHIP, APPLICATIONS) (0.5 CFU)

Contents

1) FIRST MODULE (BIOMATERIALS: CHEMICAL STRUCTURES AND PHYSICAL PROPERTIES; PROF. SS P. RIZZO):
STRUCTURAL CHARACTERISTICS OF MATERIALS AND THE RELATIVE PHYSICAL PROPERTIES.
CRYSTALLINE STRUCTURES OF METALS, ALLOYS, CERAMIC MATERIALS, COMPOSITE MATERIALS AND POLYMERIC MATERIALS.
IMPERFECTIONS PRESENT IN SOLIDS, TIMELY DEFECTS AND DISCOVERY HIGHLIGHTING AS THEIR PRESENCE ALTER THE PROPERTIES OF THE SAME MATERIALS EXTENDING FOR EXAMPLE THE RESISTANCE.
MAIN TECHNIQUES OF CHARACTERIZATION OF THE MATERIALS AND IN PARTICULAR THE TECHNIQUES FOR THE DETERMINATION OF THE CRYSTALLINE STRUCTURES OF THE SOLIDS AND THE MICROSCOPIC STRUCTURES, SUCH AS THE DETERMINATION OF GRAIN DIMENSIONS (TEM, SEM), WILL BE DESCRIBED BRIEFLY.
TRANSFORMATION OF THE MICROSTRUCTURE AND THEREFORE THE PROPERTIES OF THE MATERIALS HAVE THE SAME AS EXAMPLE THERMAL PROPERTIES (THERMAL CAPACITY, THERMAL EXPANSION, THERMAL CONDUCTIVITY) AND THOSE OPTICS.

2) SECOND MODULE (BIOMATERIALS: MEDICAL DEVICES AND INTERACTION WITH BIOLOGICAL SYSTEMS; PROF. C. DANIEL):
BIOMATERIALS AND BIOCOMPATIBILITY, BIO-INERTIA AND BIO-ACTIVITY, DEFINITIONS. (0.5 CFU)
INTRODUCTION TO CLASSES OF MATERIALS USED IN MEDICINE (CERAMIC, METALLIC, POLYMERIC, COMPOSITE). (0.5 CFU)
THERAPEUTIC ISSUES AND PROBLEMS (ORTHOPEDICS, DENTISTRY, CARDIOVASCULAR DEVICES, CATHETER, OPHTHALMOLOGY, NEFROLOGY, CONTROLLED RELEASE OF DRUGS, ETC.) (0.5 CFU)
CERAMIC BIOMATERIALS (PREPARATION TECHNIQUES, PROPERTIES-STRUCTURE RELATIONSHIP, ADVANTAGES AND DISADVANTAGES, APPLICATIONS) (0.5 CFU)
METALLIC BIOMATERIALS (METALS AND ALLOYS, PROPERTY-STRUCTURE RELATIONSHIPS, BENEFITS AND FAULTS, APPLICATIONS). (0.5 CFU)
POLYMERIC BIOMATERIALS (DEFINITIONS AND CLASSIFICATIONS, SYNTHESIS, SOLID STATE AND PROPERTY-STRUCTURE RELATIONSHIPS, APPLICATIONS FOR POLYMER CLASSES). (1 CFU)
COMPOSITE BIOMATERIALS (DEFINITIONS, PREPARATION, PROPERTY-STRUCTURE RELATIONSHIP, APPLICATIONS). (1 CFU)
PROBLEMS ASSOCIATED WITH IMPLANTS (INFECTIONS) AND POSSIBLE SOLUTION (STERILIZATION TECHNIQUES). (0.5 CFU)
BIOMATERIALS WITH ANTIMICROBIC ACTIVITY. (0.5 CFU)
HYDROGELS (DEFINITIONS, PREPARATION, PROPERTY-STRUCTURE RELATIONSHIP, APPLICATIONS) (0.5 CFU)

	Teaching Methods
	THE COURSE IS ESSENTIALLY CONSTITUTED FROM FRONT LESSONS. VISITS TO MATERIAL CHARACTERIZATION LABORATORIES ARE ALSO PLANNED, DURING WHICH THE MAIN INSTRUMENTS USED IN THIS FIELD WILL BE SHOWN AND DESCRIBED.

	Verification of learning
	THE EXAMINATION HAS THE AIM OF ASSESSING THE REACHING OF THE FORMATIVE OBJECTIVES BY THE STUDENT. THE ACHIEVEMENT OF THE OBJECTIVES OF THE TEACHING IS VERIFIED BY PASSING AN EXAMINATION WITH EVALUATION IN 30TH. THE EXAMINATION SHALL INCLUDE TWO ORAL TESTS, ONE AT THE END OF EACH MODULE. EACH TEST SHALL BE EVALUATED IN 30TH AND SHALL BE PASSED WITH A MINIMUM OF 18/30. THE FINAL MARK IS THE AVERAGE OF THE VOTES RECORDED IN EACH ORAL TEST. ALTERNATIVELY, THE STUDENT WILL BE ABLE TO TAKE A SINGLE ORAL EXAMINATION ON THE TOPICS PRESENTED IN BOTH MODULES.

Verification of learning

THE EXAMINATION HAS THE AIM OF ASSESSING THE REACHING OF THE FORMATIVE OBJECTIVES BY THE STUDENT. THE ACHIEVEMENT OF THE OBJECTIVES OF THE TEACHING IS VERIFIED BY PASSING AN EXAMINATION WITH EVALUATION IN 30TH. THE EXAMINATION SHALL INCLUDE TWO ORAL TESTS, ONE AT THE END OF EACH MODULE. EACH TEST SHALL BE EVALUATED IN 30TH AND SHALL BE PASSED WITH A MINIMUM OF 18/30. THE FINAL MARK IS THE AVERAGE OF THE VOTES RECORDED IN EACH ORAL TEST. ALTERNATIVELY, THE STUDENT WILL BE ABLE TO TAKE A SINGLE ORAL EXAMINATION ON THE TOPICS PRESENTED IN BOTH MODULES.

	Texts
	-SCIENZA E INGEGNERIA DEI MATERIALI III ED. WILLIAM D. CALLISTER, DAVID G.RETHWISCH EDIZIONE EDISES SRL 2012 NAPOLI -AN INTRODUCTION TO MATERIALS IN MEDICINE EDITED BY:BUDDY D. RATNER, ALLAN S. HOFFMAN, FREDERICK J. SCHOEN AND JACK E. LEMONS ISBN: 978-0-12-374626-9 THE SLIDES OF THE LECTURES WILL BE GIVEN TO THE STUDENTS

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Christophe DANIEL | BIOMATERIALS