Milena MASULLO | PLANT METABOLITES AND PHARMACOGNOSY

cod. 0712100104

PLANT METABOLITES AND PHARMACOGNOSY

	0712100104
	DIPARTIMENTO DI FARMACIA
	EQF6
	HERBAL SCIENCE
	2024/2025

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 2
	YEAR OF DIDACTIC SYSTEM 2020
	SPRING SEMESTER

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
	BIO/15	9	72	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	MILENA MASULLO T Curriculum
	ANTONIETTA CERULLI Curriculum

	Objectives
	ACQUISITION OF KNOWLEDGE ON THE PLANT ORIGIN, MORPHOLOGY, CHEMICAL COMPOSITION, BIOLOGICAL ACTIVITY AND USE OF HERBAL DRUGS AND DERIVED PREPARATIONS. THE STUDENT, ON THE BASIS OF THE ACQUIRED SKILLS, WILL BE ABLE TO ELABORATE CRITERIA TO RECOGNIZE AND USE THE HERBAL DRUGS. ACQUISION OF KNOWLEDGE ON PLANT METABOLISM, WITH PARTICULAR ATTENTION TO PLANT SECONDARY METABOLITES. THE STUDENT, ON THE BASIS OF THE ACQUIRED SKILLS, WILL BE ABLE TO UNDERSTAND AND CORRELATE THE MAIN CLASSES OF NATURAL PRODUCTS.

ACQUISITION OF KNOWLEDGE ON THE PLANT ORIGIN, MORPHOLOGY, CHEMICAL COMPOSITION, BIOLOGICAL ACTIVITY AND USE OF HERBAL DRUGS AND DERIVED PREPARATIONS. THE STUDENT, ON THE BASIS OF THE ACQUIRED SKILLS, WILL BE ABLE TO ELABORATE CRITERIA TO RECOGNIZE AND USE THE HERBAL DRUGS.
ACQUISION OF KNOWLEDGE ON PLANT METABOLISM, WITH PARTICULAR ATTENTION TO PLANT SECONDARY METABOLITES. THE STUDENT, ON THE BASIS OF THE ACQUIRED SKILLS, WILL BE ABLE TO UNDERSTAND AND CORRELATE THE MAIN CLASSES OF NATURAL PRODUCTS.

	Prerequisites
	PLANT BIOLOGY, PHARMACEUTICAL BOTANY, AND ORGANIC CHEMISTRY

	Contents
	DEFINITION OF HERBAL DRUG AND ACTIVE PRINCIPLE; PLANT NOMENCLATURE AND TAXONOMY (2 H). ORGANIZED AND NOT ORGANIZED HERBAL DRUGS (4 H). EXTRACTIVE METHODS AND PLANT EXTRACTS WITH PRACTICAL ACTIVITIES (6 H). CONSERVATION, STABILITY AND VARIABILITY OF HERBAL DRUGS AND DERIVED PREPARATIONS. ELEMENTS OF QUALITY CONTROL (4 H). PRIMARY AND SECONDARY METABOLITES (2 H). BASIC PRINCIPLES OF THE PRIMARY METABOLISM AND THE MAIN PATHWAYS OF SECONDARY METABOLISM, DEFINITION AND SYSTEMATICS OF SECONDARY METABOLITES (4H). FOR EACH HERBAL DRUG: BOTANICAL SOURCE, MACROSCOPIC AND MICROSCOPIC CHARACTERS, QUALI-QUANTITATIVE CHEMICAL PROFILE, BIOACTIVE CONSTITUENTS, BIOLOGICAL ACTIVITY OF HERBAL DRUGS AND ACTIVE PRINCPLES. BIOSYNTHETIC PATHWAY OF CARBOHYDRATES: MONOSACCARIDES, DISACCHARIDES, POLISACCHARIDES, STARCH. HERBAL DRUGS EMPLOYED FOR THEIR CONTENT IN CARBOHYDRATES (2 H). LIPIDS AND RELATIVE HERBAL DRUGS (1 H). RESINS AND BALMS (1H). BIOSYNTHETIC PATHWAY OF SHIKIMATE. (PHENOLS, POLYPHENOLS, PHENYLPROPANOIDS, COUMARINS, LIGNANS) AND RELATIVE DRUGS (8 H). BIOSYNTHETIC PATHWAY OF ACETATE (ANTRAQUINONES AND FLAVONOIDS) (4H). ANTRAQUINONE DRUGS (2H). BIOSYNTHETIC PATHWAY OF MEVALONATE (2H). THE ROLE OF TERPENOIDS IN PLANT DEFENSE. TERPENOIDS: LOCALIZATION, BIOLOGICAL ACTIVITY. STRUCTURAL FEATURES OF MONOTERPENES, IRIDOIDS, SESQUITERPENES, DITERPENES (6 H). CHEMICAL FEATURES OF TRITERPENES, STEROIDS, SAPONINS AND RELATIVE DRUGS (6 H). CARDIAC GLYCOSIDES AND RELATIVE DRUGS (4 H). ALKALOIDS CLASSIFICATION (2 H). BASIC PRINCIPLES OF THE ALKALOIDS BIOSYNTHESIS: ALKALOIDS DERIVING FROM ORNITHINE, LISINE, PHENYLALANINE, TYROSINE, AND TRYPTOPHAN; DRUGS USED FOR THEIR ALKALOID CONTENT (12 H).

Contents

DEFINITION OF HERBAL DRUG AND ACTIVE PRINCIPLE; PLANT NOMENCLATURE AND TAXONOMY (2 H). ORGANIZED AND NOT ORGANIZED HERBAL DRUGS (4 H). EXTRACTIVE METHODS AND PLANT EXTRACTS WITH PRACTICAL ACTIVITIES (6 H). CONSERVATION, STABILITY AND VARIABILITY OF HERBAL DRUGS AND DERIVED PREPARATIONS. ELEMENTS OF QUALITY CONTROL (4 H). PRIMARY AND SECONDARY METABOLITES (2 H).
BASIC PRINCIPLES OF THE PRIMARY METABOLISM AND THE MAIN PATHWAYS OF SECONDARY METABOLISM, DEFINITION AND SYSTEMATICS OF SECONDARY METABOLITES (4H). FOR EACH HERBAL DRUG: BOTANICAL SOURCE, MACROSCOPIC AND MICROSCOPIC CHARACTERS, QUALI-QUANTITATIVE CHEMICAL PROFILE, BIOACTIVE CONSTITUENTS, BIOLOGICAL ACTIVITY OF HERBAL DRUGS AND ACTIVE PRINCPLES. BIOSYNTHETIC PATHWAY OF CARBOHYDRATES: MONOSACCARIDES, DISACCHARIDES, POLISACCHARIDES, STARCH. HERBAL DRUGS EMPLOYED FOR THEIR CONTENT IN CARBOHYDRATES (2 H). LIPIDS AND RELATIVE HERBAL DRUGS (1 H). RESINS AND BALMS (1H). BIOSYNTHETIC PATHWAY OF SHIKIMATE. (PHENOLS, POLYPHENOLS, PHENYLPROPANOIDS, COUMARINS, LIGNANS) AND RELATIVE DRUGS (8 H). BIOSYNTHETIC PATHWAY OF ACETATE (ANTRAQUINONES AND FLAVONOIDS) (4H). ANTRAQUINONE DRUGS (2H). BIOSYNTHETIC PATHWAY OF MEVALONATE (2H). THE ROLE OF TERPENOIDS IN PLANT DEFENSE. TERPENOIDS: LOCALIZATION, BIOLOGICAL ACTIVITY. STRUCTURAL FEATURES OF MONOTERPENES, IRIDOIDS, SESQUITERPENES, DITERPENES (6 H). CHEMICAL FEATURES OF TRITERPENES, STEROIDS, SAPONINS AND RELATIVE DRUGS (6 H). CARDIAC GLYCOSIDES AND RELATIVE DRUGS (4 H). ALKALOIDS CLASSIFICATION (2 H). BASIC PRINCIPLES OF THE ALKALOIDS BIOSYNTHESIS: ALKALOIDS DERIVING FROM ORNITHINE, LISINE, PHENYLALANINE, TYROSINE, AND TRYPTOPHAN; DRUGS USED FOR THEIR ALKALOID CONTENT (12 H).

	Teaching Methods
	LECTURES, SEMINARS, TUTORIALS

	Verification of learning
	THE EXAMINATION CONSISTS OF A WRITTEN AND ORAL TEST TO BE SUSTAINED IN THE SAME EXAM SESSION. THE RATING IS X/30. PASS THE WRITTEN TEST WITH A SCORE OF 18/30, IT IS MANDATORY TO BE ABLE TO TAKE THE ORAL TEST, AND REACH THE FINAL GRADE. THE WRITTEN TEST TAKES TWO HOURS AND CONSISTS OF OPEN QUESTIONS ON THE MAIN LEARNING OUTCOMES OF PHARMACOGNOSY AND PHYTOCHEMISTRY. THE STUDENT WILL BE ASKED TO DISCUSS THE MAIN TOPICS OF THE COURSE, TRYING TO DEMONSTRATE CRITICAL THOUGHT AND AWARENESS OF THE SUBJECTS OF THE FIELD OF STUDY. DURING THE COURSE, THE STUDENT ALSO HAS THE POSSIBILITY TO CARRY OUT 3 PARTIAL TESTS, CONSISTING OF OPEN QUESTIONS (2 HOURS). THE PASSING OF THE PARTIAL TESTS MAY EXEMPT FROM THE PERFORMANCE OF THE WRITTEN TEST. THE EXEMPTION APPLIES EXCLUSIVELY TO THE EXAMINATION SESSION IMMEDIATELY AFTER THE TEACHING SESSION.

Verification of learning

THE EXAMINATION CONSISTS OF A WRITTEN AND ORAL TEST TO BE SUSTAINED IN THE SAME EXAM SESSION. THE RATING IS X/30. PASS THE WRITTEN TEST WITH A SCORE OF 18/30, IT IS MANDATORY TO BE ABLE TO TAKE THE ORAL TEST, AND REACH THE FINAL GRADE. THE WRITTEN TEST TAKES TWO HOURS AND CONSISTS OF OPEN QUESTIONS ON THE MAIN LEARNING OUTCOMES OF PHARMACOGNOSY AND PHYTOCHEMISTRY.
THE STUDENT WILL BE ASKED TO DISCUSS THE MAIN TOPICS OF THE COURSE, TRYING TO DEMONSTRATE CRITICAL THOUGHT AND AWARENESS OF THE SUBJECTS OF THE FIELD OF STUDY.
DURING THE COURSE, THE STUDENT ALSO HAS THE POSSIBILITY TO CARRY OUT 3 PARTIAL TESTS, CONSISTING OF OPEN QUESTIONS (2 HOURS). THE PASSING OF THE PARTIAL TESTS MAY EXEMPT FROM THE PERFORMANCE OF THE WRITTEN TEST. THE EXEMPTION APPLIES EXCLUSIVELY TO THE EXAMINATION SESSION IMMEDIATELY AFTER THE TEACHING SESSION.

	Texts
	DEWICK PAUL M., CHIMICA, BIOSINTESI E BIOATTIVITÀ DELLE SOSTANZE NATURALI 2/ED.- EDIZIONE ITALIANA A CURA DI ERNESTO FATTORUSSO [DEWICK - PICCIN EDITORE] MANN J. CHEMICAL ASPECTS OF BIOSYNTHESIS, CHEMISTRY PRIMERS, OXFORD. MAZZANTI G., DELL'AGLI M, IZZO A.A. FARMACOGNOSIA E FITOTERAPIA BASI FARMACOLOGICHE E ASPETTI APPLICATIVI, PICCIN, PADOVA. G. SAMUELSSON FARMACOGNOSIA - FARMACI DI ORIGINE NATURALE. SECONDA EDIZIONE ITALIANA A CURA DI: F. CAPASSO, R. DE PASQUALE, I. MORELLI, CASA EDITRICE EMSI, ROMA. F. CAPASSO, R. DE PASQUALE, G. GRANDOLINI, N. MASCOLO. FARMACOGNOSIA: FARMACI NATURALI, LORO PREPARAZIONI ED IMPIEGO TERAPEUTICO, CASA EDITRICE: SPRINGER-VERLAG

Texts

DEWICK PAUL M., CHIMICA, BIOSINTESI E BIOATTIVITÀ DELLE SOSTANZE NATURALI 2/ED.- EDIZIONE ITALIANA A CURA DI ERNESTO FATTORUSSO [DEWICK - PICCIN EDITORE]
MANN J. CHEMICAL ASPECTS OF BIOSYNTHESIS, CHEMISTRY PRIMERS, OXFORD.
MAZZANTI G., DELL'AGLI M, IZZO A.A. FARMACOGNOSIA E FITOTERAPIA BASI FARMACOLOGICHE E ASPETTI APPLICATIVI, PICCIN, PADOVA.
G. SAMUELSSON FARMACOGNOSIA - FARMACI DI ORIGINE NATURALE. SECONDA EDIZIONE ITALIANA A CURA DI: F. CAPASSO, R. DE PASQUALE, I. MORELLI, CASA EDITRICE EMSI, ROMA.
F. CAPASSO, R. DE PASQUALE, G. GRANDOLINI, N. MASCOLO.
FARMACOGNOSIA: FARMACI NATURALI, LORO PREPARAZIONI ED IMPIEGO TERAPEUTICO, CASA EDITRICE: SPRINGER-VERLAG

	More Information
	MILENA MASULLO HTTP://DOCENTI.UNISA.IT/MILENA.MASULLO ANTONIETTA CERULLI

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Milena MASULLO | PLANT METABOLITES AND PHARMACOGNOSY