Giacomo PEPE | ANALYSIS OF DRUGS 1

cod. 0760100100

ANALYSIS OF DRUGS 1

	0760100100
	DIPARTIMENTO DI FARMACIA
	EQF7
	PHARMACY
	2021/2022

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 2
	YEAR OF DIDACTIC SYSTEM 2020
	SPRING SEMESTER

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	LEZIONI MODULO DI ANALISI DEI FARMACI I
	CHIM/08	6	48	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
2	LABORATORIO MODULO DI ANALISI DEI FARMACI I
	CHIM/08	6	72	LAB	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	GIACOMO PEPE1 T Curriculum
	SIMONA MUSELLA2 Curriculum

	Objectives
	The course is focused to provide the knowledge and comprehension of methods related to quantitative determination by classical physicochemical and instrumental techniques of both natural and synthetic drugs reported in Italian and European pharmacopoeia as well as those contained in galenical preparations and in the main pharmaceutical entities. The student applying the acquired skills will be able to choose and apply the most appropriate analytical workflow for the determination of bioactive substances in Italian and European pharmacopoeia and for quality control of health products

The course is focused to provide the knowledge and comprehension of methods related to quantitative determination by classical physicochemical and instrumental techniques of both natural and synthetic drugs reported in Italian and European pharmacopoeia as well as those contained in galenical preparations and in the main pharmaceutical entities.
The student applying the acquired skills will be able to choose and apply the most appropriate analytical workflow for the determination of bioactive substances in Italian and European pharmacopoeia and for quality control of health products

	Prerequisites
	FOR THIS COURSE, IT IS NECESSARY THE ACQUISITION OF THE OBJECTIVES OF: GENERAL AND INORGANIC CHEMISTRY. MOREOVER, THE ACQUISITION OF BASIC PRINCIPLES OF ANALYTICAL AND ORGANIC CHEMISTRY IS STRONGLY RECOMMENDED.

	Contents
	SAFETY IN LABORATORIES. REGULATIONS. THE ITALIAN OFFICIAL PHARMACOPOEIA (F.U.). THE EUROPEAN PHARMACOPOEIA (E.P.). GLASSWARE AND ITS USE. ELECTRONIC SCALES, CONCENTRATION UNITS. (4 HOURS). SCALE OF WORK . NORMALITY, EQUIVALENT, CALCULATIONS IN VOLUMETRIC ANALYSIS (4 HOURS). ANALYSIS OF THE PH OF STRONG AND WEAK ACIDS AND BASES. CALCULATION OF PH OF POLYPROTIC ACIDS AND THEIR SALTS. TITRATION CURVES OF ACIDS AND BASES. THEORY OF INDICATORS. MAIN ACID-BASE INDICATORS AND THEIR USE. PRIMARY STANDARDS, THEIR CHARACTERISTICS AND THEIR USE. STANDARD SOLUTIONS OF ACIDS AND BASES USED IN VOLUMETRIC ANALYSIS. EXAMPLES OF TITRATIONS ACCORDING TO E.P. (10 HOURS) SOLUBILITY. SOLUBILITY PRODUCT. PRECIPITATION AND REDISSOLUTION OF THE PRECIPITATES. COLLOIDAL PRECIPITATES (4 HOURS). TITRATION CURVES OF PRECIPITATION. DETERMINATION OF HALIDES ACCORDING TO MOHR, VOLHARD, FAJANS AND LIEBIG-DENIGES. PREPARATION OF STANDARD SOLUTIONS USED IN PRECIPITATION ANALYSIS. EXAMPLES OF DETERMINATIONS OF PRECIPITATION (6 HOURS). TITRATIONS IN NONAQUEOUS SOLVENTS: THEORY AND APPLICATIONS (2 HOURS). COMPLEXOMETRIC TITRATION. METALLOCROMIC INDICATORS. COMPLEX-FORMATION AND INSTABILITY CONSTANTS. EXAMPLES OF COMPLEXOMETRIC TITRATIONS ACCORDING TO E.P. (4 HOURS) DEFINITION AND USE OF THE STANDARD REDUCTION POTENTIAL. REDOX INDICATORS AND SPECIFIC INDICATORS (2 HOURS). PERMANGANOMETRY. IODIMETRY. IODOMETRY. CERIMETRY. BROMATOMETRY (10 HOURS). COMPLEXATION REACTIONS.SPECTROPHOTOMETRY UV / VIS, THEORETICAL AND PRACTICAL APPLICATIONS.LAMBERT-BEER EQUATION (2 HOURS).

Contents

SAFETY IN LABORATORIES.
REGULATIONS. THE ITALIAN OFFICIAL
PHARMACOPOEIA (F.U.). THE
EUROPEAN PHARMACOPOEIA (E.P.).
GLASSWARE AND ITS USE. ELECTRONIC
SCALES, CONCENTRATION UNITS. (4
HOURS). SCALE OF WORK .
NORMALITY, EQUIVALENT,
CALCULATIONS IN VOLUMETRIC
ANALYSIS (4 HOURS).
ANALYSIS OF THE PH OF STRONG AND
WEAK ACIDS AND BASES. CALCULATION
OF PH OF POLYPROTIC ACIDS AND
THEIR SALTS. TITRATION CURVES OF
ACIDS AND BASES. THEORY OF
INDICATORS. MAIN ACID-BASE
INDICATORS AND THEIR USE. PRIMARY
STANDARDS, THEIR CHARACTERISTICS
AND THEIR USE. STANDARD SOLUTIONS
OF ACIDS AND BASES USED IN
VOLUMETRIC ANALYSIS. EXAMPLES OF
TITRATIONS ACCORDING TO E.P. (10
HOURS)
SOLUBILITY. SOLUBILITY PRODUCT.
PRECIPITATION AND REDISSOLUTION
OF THE PRECIPITATES. COLLOIDAL
PRECIPITATES (4 HOURS).
TITRATION CURVES OF PRECIPITATION.
DETERMINATION OF HALIDES
ACCORDING TO MOHR, VOLHARD,
FAJANS AND LIEBIG-DENIGES.
PREPARATION OF STANDARD
SOLUTIONS USED IN PRECIPITATION
ANALYSIS. EXAMPLES OF
DETERMINATIONS OF PRECIPITATION (6
HOURS).
TITRATIONS IN NONAQUEOUS
SOLVENTS: THEORY AND APPLICATIONS
(2 HOURS).
COMPLEXOMETRIC TITRATION.
METALLOCROMIC INDICATORS.
COMPLEX-FORMATION AND
INSTABILITY CONSTANTS. EXAMPLES OF
COMPLEXOMETRIC TITRATIONS
ACCORDING TO E.P. (4 HOURS)
DEFINITION AND USE OF THE
STANDARD REDUCTION POTENTIAL.

REDOX INDICATORS AND SPECIFIC
INDICATORS (2 HOURS).
PERMANGANOMETRY. IODIMETRY.
IODOMETRY. CERIMETRY.
BROMATOMETRY (10 HOURS).
COMPLEXATION
REACTIONS.SPECTROPHOTOMETRY UV
/ VIS, THEORETICAL AND PRACTICAL
APPLICATIONS.LAMBERT-BEER
EQUATION (2 HOURS).

	Teaching Methods
	THE COURSE IS MADE OF 120 HOURS OF LESSONS (12 CFU), 48 HOURS OF FRONTAL LESSONS (6 CFU) AND 72 HOURS OF LAB EXPERIENCES (6 CFU). THE ATTENDANCE IS MANDATORY. EVERY TWO WEEKS, DURING FRONTAL LESSONS, EXERCISES CONCERNING THE TOPICS DISCUSSED WILL BE PERFORMED. THE LESSONS ARE MANDATORY, THE FREQUENCY OF AT LEAST 75% OF LABORATORY LESSONS IS REQUIRED FOR THE ACCESS TO THE EXAM.

	Verification of learning
	THE EXAM CONSINSTS IN TWO DIFFERENT TESTS. THE ACHIEVEMENT OF EACH TEST IS MANDATORY FOR THE NEXT ONE. THE FIRST IS A WRITTEN TEST COMPOSED BY 5 DIFFERENT ANALYTICAL PROBLEMS OF WHICH AT LEAST THREE HAVE TO BE SOLVED. THE SECOND TEST IS AN ORAL EXAMINATION OF ABOUT 20 MINUTES WITH THE AIM TO VERIFY THE THEORETICAL AND METHODOLOGICAL KNOWLEDGE OF THE STUDENT. THE FINAL MARK WILL TAKE IN ACCOUNT THE RESULTS OF THE WRITTEN AND THE ORAL TESTS.

Verification of learning

THE EXAM CONSINSTS IN TWO DIFFERENT TESTS. THE ACHIEVEMENT OF EACH TEST IS MANDATORY FOR THE NEXT ONE.
THE FIRST IS A WRITTEN TEST COMPOSED BY 5 DIFFERENT ANALYTICAL PROBLEMS OF WHICH AT LEAST THREE HAVE TO BE SOLVED.
THE SECOND TEST IS AN ORAL EXAMINATION OF ABOUT 20 MINUTES WITH THE AIM TO VERIFY THE THEORETICAL AND METHODOLOGICAL KNOWLEDGE OF THE STUDENT.

THE FINAL MARK WILL TAKE IN ACCOUNT THE RESULTS OF THE WRITTEN AND THE ORAL TESTS.

	Texts
	A. CARRIERI - MANUALE DI ANALISI QUANTITATIVA DEI MEDICINALI - EDISES F. J. HOLLER & S. R. CROUCH - FONDAMENTI DI CHIMICA ANALITICA - EDISES DAVID G WATSON - ANALISI FARMACEUTICA - EDISES DAVID S HAGE & JAMES D CARR - CHIMICA ANALITICA ED ANALISI QUANTITATIVA - PICCIN DANIEL C HARRIS - CHIMICA ANALITICA QUANTITATIVA - ZANICHELLI

	More Information
	TEACHING LANGUAGE: ITALIAN LESSON ROOMS: PHARMACY DEPARTMENT

BETA VERSION Data source ESSE3 [Ultima Sincronizzazione: 2022-11-21]

Giacomo PEPE | ANALYSIS OF DRUGS 1