VERONICA DI SARNO | ANALYSIS OF DRUGS 1

cod. 0760100100

ANALYSIS OF DRUGS 1

	0760100100
	DIPARTIMENTO DI FARMACIA
	EQF7
	PHARMACY
	2022/2023

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 2
	YEAR OF DIDACTIC SYSTEM 2020
	SPRING SEMESTER

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	LEZIONI MODULO DI ANALISI DEI FARMACI I
	CHIM/08	6	48	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
2	LABORATORIO MODULO DI ANALISI DEI FARMACI I
	CHIM/08	6	72	LAB	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	VERONICA DI SARNO1 T Curriculum
	SIMONA MUSELLA2 Curriculum

	Objectives
	THE COURSE IS FOCUSED TO PROVIDE THE KNOWLEDGE AND COMPREHENSION OF METHODS RELATED TO QUANTITATIVE DETERMINATION BY CLASSICAL PHYSICOCHEMICAL AND INSTRUMENTAL TECHNIQUES OF BOTH NATURAL AND SYNTHETIC DRUGS REPORTED IN ITALIAN AND EUROPEAN PHARMACOPOEIA AS WELL AS THOSE CONTAINED IN GALENICAL PREPARATIONS AND IN THE MAIN PHARMACEUTICAL ENTITIES. THE STUDENT APPLYING THE ACQUIRED SKILLS WILL BE ABLE TO CHOOSE AND APPLY THE MOST APPROPRIATE ANALYTICAL WORKFLOW FOR THE DETERMINATION OF BIOACTIVE SUBSTANCES IN ITALIAN AND EUROPEAN PHARMACOPOEIA AND FOR QUALITY CONTROL OF HEALTH PRODUCTS

THE COURSE IS FOCUSED TO PROVIDE THE KNOWLEDGE AND COMPREHENSION OF METHODS RELATED TO QUANTITATIVE DETERMINATION BY CLASSICAL PHYSICOCHEMICAL AND INSTRUMENTAL TECHNIQUES OF BOTH NATURAL AND SYNTHETIC DRUGS REPORTED IN ITALIAN AND EUROPEAN PHARMACOPOEIA AS WELL AS THOSE CONTAINED IN GALENICAL PREPARATIONS AND IN THE MAIN PHARMACEUTICAL ENTITIES. THE STUDENT APPLYING THE ACQUIRED SKILLS WILL BE ABLE TO CHOOSE AND APPLY THE MOST APPROPRIATE ANALYTICAL WORKFLOW FOR THE DETERMINATION OF BIOACTIVE SUBSTANCES IN ITALIAN AND EUROPEAN PHARMACOPOEIA AND FOR QUALITY CONTROL OF HEALTH PRODUCTS

	Prerequisites
	THE STUDENT MUST HAVE PASSED THE GENERAL AND INORGANIC CHEMISTRY TEST, IN ADDITION, THE ACQUISITION OF THE ORGANIC CHEMISTRY COURSE AND A BASIC KNOWLEDGE OF THE ENGLISH LANGUAGE AND COMPUTER SCIENCE ARE STRONGLY RECOMMENDED.

	Contents
	LECTURES (48 HOURS - 6 ECTS) SAFETY IN LABORATORIES. REGULATIONS. THE ITALIAN OFFICIAL PHARMACOPOEIA (F.U.). THE EUROPEAN PHARMACOPOEIA (E.P.). GLASSWARE AND ITS USE. ELECTRONIC SCALES, CONCENTRATION UNITS. (4 HOURS). SCALE OF WORK. NORMALITY, EQUIVALENT, CALCULATIONS IN VOLUMETRIC ANALYSIS (4 HOURS). ANALYSIS OF THE PH OF STRONG AND WEAK ACIDS AND BASES. CALCULATION OF PH OF POLYPROTIC ACIDS AND THEIR SALTS. TITRATION CURVES OF ACIDS AND BASES. THEORY OF INDICATORS. MAIN ACID-BASE INDICATORS AND THEIR USE. PRIMARY STANDARDS, THEIR CHARACTERISTICS AND THEIR USE. STANDARD SOLUTIONS OF ACIDS AND BASES USED IN VOLUMETRIC ANALYSIS. EXAMPLES OF TITRATIONS ACCORDING TO E.P. (10 HOURS) SOLUBILITY. SOLUBILITY PRODUCT. PRECIPITATION AND REDISSOLUTION OF THE PRECIPITATES. COLLOIDAL PRECIPITATES (4 HOURS). TITRATION CURVES OF PRECIPITATION. DETERMINATION OF HALIDES ACCORDING TO MOHR, VOLHARD, FAJANS AND LIEBIG-DENIGES. PREPARATION OF STANDARD SOLUTIONS USED IN PRECIPITATION ANALYSIS. EXAMPLES OF DETERMINATIONS OF PRECIPITATION (6 HOURS). TITRATIONS IN NONAQUEOUS SOLVENTS: THEORY AND APPLICATIONS (2 HOURS). COMPLEXOMETRIC TITRATION. METALLOCROMIC INDICATORS. COMPLEX-FORMATION AND INSTABILITY CONSTANTS. EXAMPLES OF COMPLEXOMETRIC TITRATIONS ACCORDING TO E.P. (4 HOURS) DEFINITION AND USE OF THE STANDARD REDUCTION POTENTIAL. REDOX INDICATORS AND SPECIFIC INDICATORS (2 HOURS). PERMANGANOMETRY. IODIMETRY. IODOMETRY. CERIMETRY. BROMATOMETRY (8 HOURS). COMPLEXATION REACTIONS.SPECTROPHOTOMETRY UV / VIS, THEORETICAL AND PRACTICAL APPLICATIONS.LAMBERT-BEER EQUATION (2 HOURS). QUANTITATIVE ANALYSIS USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (2 HOURS). PRACTICALS (72 HOURS - 6 ECTS) STANDARDIZATION OF SODIUM HYDROXIDE SOLUTION AND QUANTITATIVE DETERMINATION OF A MONOPROTIC ACID AND A POLYPROTIC ACID (6 ORE - 0.5 ECTS) STANDARDIZATION OF HYDROCHLORIC ACID SOLUTION AND QUANTITATIVE DETERMINATION OF SODIUM HIDROXIDE AND SODIUM CARBONATE (6 ORE - 0.5 ECTS) MOHR, FAJANS AND VOLHARD METHOD (6 ORE - 0.5 ECTS) STANDARDIZATION OF EDTA SOLUTION AND DETERMINATION OF CALCIUM AND MAGNESIUM (6 ORE - 0.5 ECTS) STANDARDIZATION OF POTASSIUM PERMANGANATE SOLUTION AND DETERMINATION OF THE TITLE AND OXYGEN VOLUMES OF HYDROGEN PEROXIDE SOLUTION (6 ORE - 0.5 ECTS) STANDARDIZATION OF IODINE SOLUTION AND QUANTITATIVE DETERMINATION OF THE ASCORBIC ACID (6 ORE - 0.5 ECTS) TITRATIONS IN NON-AQUEOUS SOLVENTS: QUANTITATIVE DETERMINATION OF CAFFEINE AND LIDOCAINE (6 ORE - 0.5 ECTS) QUANTITATIVE DETERMINATION BY SPECTROPHOTOMETRIC ANALYSIS (UV / VIS) (6 ORE - 0.5 ECTS) APPLICATION OF MICROSOFT EXCEL IN ANALYTICAL CHEMISTRY (6 ORE - 0.5 ECTS) GUIDED RESOLUTION AND RELATIVE CRITICAL DISCUSSION OF CALCULATION EXERCISES CONCERNING THE TOPICS COVERED (18 HOURS - 1.5 ECTS)

Contents

LECTURES (48 HOURS - 6 ECTS)

SAFETY IN LABORATORIES. REGULATIONS. THE ITALIAN OFFICIAL PHARMACOPOEIA (F.U.). THE EUROPEAN PHARMACOPOEIA (E.P.). GLASSWARE AND ITS USE. ELECTRONIC SCALES, CONCENTRATION UNITS. (4 HOURS).
SCALE OF WORK. NORMALITY, EQUIVALENT, CALCULATIONS IN VOLUMETRIC ANALYSIS (4 HOURS).
ANALYSIS OF THE PH OF STRONG AND WEAK ACIDS AND BASES. CALCULATION OF PH OF POLYPROTIC ACIDS AND THEIR SALTS. TITRATION CURVES OF ACIDS AND BASES. THEORY OF INDICATORS. MAIN ACID-BASE INDICATORS AND THEIR USE. PRIMARY STANDARDS, THEIR CHARACTERISTICS AND THEIR USE. STANDARD SOLUTIONS OF ACIDS AND BASES USED IN VOLUMETRIC ANALYSIS. EXAMPLES OF TITRATIONS ACCORDING TO E.P. (10 HOURS)
SOLUBILITY. SOLUBILITY PRODUCT. PRECIPITATION AND REDISSOLUTION OF THE PRECIPITATES. COLLOIDAL PRECIPITATES (4 HOURS).
TITRATION CURVES OF PRECIPITATION. DETERMINATION OF HALIDES ACCORDING TO MOHR, VOLHARD, FAJANS AND LIEBIG-DENIGES. PREPARATION OF STANDARD SOLUTIONS USED IN PRECIPITATION ANALYSIS. EXAMPLES OF DETERMINATIONS OF PRECIPITATION (6 HOURS).
TITRATIONS IN NONAQUEOUS SOLVENTS: THEORY AND APPLICATIONS (2 HOURS).
COMPLEXOMETRIC TITRATION. METALLOCROMIC INDICATORS. COMPLEX-FORMATION AND INSTABILITY CONSTANTS. EXAMPLES OF COMPLEXOMETRIC TITRATIONS ACCORDING TO E.P. (4 HOURS)
DEFINITION AND USE OF THE STANDARD REDUCTION POTENTIAL. REDOX INDICATORS AND SPECIFIC INDICATORS (2 HOURS). PERMANGANOMETRY. IODIMETRY. IODOMETRY. CERIMETRY. BROMATOMETRY (8 HOURS).
COMPLEXATION REACTIONS.SPECTROPHOTOMETRY UV / VIS, THEORETICAL AND PRACTICAL APPLICATIONS.LAMBERT-BEER EQUATION (2 HOURS).
QUANTITATIVE ANALYSIS USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (2 HOURS).

PRACTICALS (72 HOURS - 6 ECTS)

STANDARDIZATION OF SODIUM HYDROXIDE SOLUTION AND QUANTITATIVE DETERMINATION OF A MONOPROTIC ACID AND A POLYPROTIC ACID (6 ORE - 0.5 ECTS)
STANDARDIZATION OF HYDROCHLORIC ACID SOLUTION AND QUANTITATIVE DETERMINATION OF SODIUM HIDROXIDE AND SODIUM CARBONATE (6 ORE - 0.5 ECTS)
MOHR, FAJANS AND VOLHARD METHOD (6 ORE - 0.5 ECTS)
STANDARDIZATION OF EDTA SOLUTION AND DETERMINATION OF CALCIUM AND MAGNESIUM (6 ORE - 0.5 ECTS)
STANDARDIZATION OF POTASSIUM PERMANGANATE SOLUTION AND DETERMINATION OF THE TITLE AND OXYGEN VOLUMES OF HYDROGEN PEROXIDE SOLUTION (6 ORE - 0.5 ECTS)
STANDARDIZATION OF IODINE SOLUTION AND QUANTITATIVE DETERMINATION OF THE ASCORBIC ACID (6 ORE - 0.5 ECTS)
TITRATIONS IN NON-AQUEOUS SOLVENTS: QUANTITATIVE DETERMINATION OF CAFFEINE AND LIDOCAINE (6 ORE - 0.5 ECTS)
QUANTITATIVE DETERMINATION BY SPECTROPHOTOMETRIC ANALYSIS (UV / VIS) (6 ORE - 0.5 ECTS)
APPLICATION OF MICROSOFT EXCEL IN ANALYTICAL CHEMISTRY (6 ORE - 0.5 ECTS)
GUIDED RESOLUTION AND RELATIVE CRITICAL DISCUSSION OF CALCULATION EXERCISES CONCERNING THE TOPICS COVERED (18 HOURS - 1.5 ECTS)

	Teaching Methods
	THE COURSE IS MADE OF 120 HOURS OF LESSONS (12 ECTS), 48 HOURS OF FRONTAL LESSONS (6 ECTS) AND 72 HOURS OF LAB EXPERIENCES (6 ECTS). THE ATTENDANCE IS MANDATORY. EVERY WEEKS, DURING FRONTAL LESSONS, EXERCISES CONCERNING THE TOPICS DISCUSSED WILL BE PERFORMED. THE LESSONS ARE MANDATORY. THE FREQUENCY OF AT LEAST 80% OF LABORATORY LESSONS AND AT LEAST 70% OF FRONTAL LESSONS ARE REQUIRED FOR THE ACCESS TO THE EXAM.

Teaching Methods

THE COURSE IS MADE OF 120 HOURS OF LESSONS (12 ECTS), 48 HOURS OF FRONTAL LESSONS (6 ECTS) AND 72 HOURS OF LAB EXPERIENCES (6 ECTS).
THE ATTENDANCE IS MANDATORY. EVERY WEEKS, DURING FRONTAL LESSONS, EXERCISES CONCERNING THE TOPICS DISCUSSED WILL BE PERFORMED.
THE LESSONS ARE MANDATORY. THE FREQUENCY OF AT LEAST 80% OF LABORATORY LESSONS AND AT LEAST 70% OF FRONTAL LESSONS ARE REQUIRED FOR THE ACCESS TO THE EXAM.

	Verification of learning
	THE ACHIEVEMENT OF THE COURSE OBJECTIVES IS CERTIFIED BY THREE FOLLOWING TESTS. THE FIRST ONE CONSISTS IN A LABORATORY TEST CONCERNING THE TITRATION OF A SPECIFIC CHEMICAL COMPOUND. THE SECOND ONE IS A WRITING TEST COMPOSED BY 5 DIFFERENT ANALYTICAL PROBLEMS AND THE CORRECT RESOLUTION OF AT LEAST THREE PROBLEMS IS REQUIRED. THE LAST TEST IS A 20 MINUTES ORAL TEST AIMED TO ENSURE THE STUDENT’S KNOWLEDGE ABOUT THEORETICAL AND METHODOLOGICAL TOPICS. THE ORAL TEST IS ALSO AIMED TO VERIFY THE COMMUNICATION AND LANGUAGE SKILLS. THE FINAL MARK WILL TAKE IN ACCOUNT THE RESULTS OF THE PRATICAL, WRITTEN AND THE ORAL TESTS.

Verification of learning

THE ACHIEVEMENT OF THE COURSE OBJECTIVES IS CERTIFIED BY THREE FOLLOWING TESTS. THE FIRST ONE CONSISTS IN A LABORATORY TEST CONCERNING THE TITRATION OF A SPECIFIC CHEMICAL COMPOUND.
THE SECOND ONE IS A WRITING TEST COMPOSED BY 5 DIFFERENT ANALYTICAL PROBLEMS AND THE CORRECT RESOLUTION OF AT LEAST THREE PROBLEMS IS REQUIRED. THE LAST TEST IS A 20 MINUTES ORAL TEST AIMED TO ENSURE THE STUDENT’S KNOWLEDGE ABOUT THEORETICAL AND METHODOLOGICAL TOPICS. THE ORAL TEST IS ALSO AIMED TO VERIFY THE COMMUNICATION AND LANGUAGE SKILLS.
THE FINAL MARK WILL TAKE IN ACCOUNT THE RESULTS OF THE PRATICAL, WRITTEN AND THE ORAL TESTS.

	Texts
	SKOOG, WEST, HOLLER, CROUCH, FONDAMENTI DI CHIMICA ANALITICA, EDISES KOLTHOFF, SANDELL, MEEHAN, BRUCKENSTEIN, ANALISI CHIMICA QUANTITATIVA, PICCIN. WATSON, ANALISI FARMACEUTICA, EDISES KELLNER, MERMER, OTTO, WIDMER, CHIMICA ANALITICA, EDISES COZZI, PROTTI, RUARO, ANALISI CHIMICA STRUMENTALE, ZANICHELLI HARRIS D.C., CHIMICA ANALITICA QUANTITATIVA, ED. ZANICHELLI PORRETTA G.C., ANALISI DI PREPARAZIONI FARMACEUTICHE, ED. CISU -NOVELLINO E., MARSEGLIA S., IACCARINO C., ANALISI CHIMICO FARMACEUTICA QUANTITATIVA ANALITICA, EDISES COZZI, PROTTI, RUARO, ANALISI CHIMICA STRUMENTALE, ZANICHELLI HARRIS D.C., CHIMICA ANALITICA QUANTITATIVA, ED. ZANICHELLI PORRETTA G.C., ANALISI DI PREPARAZIONI FARMACEUTICHE, ED. CISU NOVELLINO E., MARSEGLIA S., IACCARINO C., ANALISI CHIMICO FARMACEUTICA QUANTITATIVA

Texts

SKOOG, WEST, HOLLER, CROUCH, FONDAMENTI DI CHIMICA ANALITICA, EDISES
KOLTHOFF, SANDELL, MEEHAN, BRUCKENSTEIN, ANALISI CHIMICA QUANTITATIVA, PICCIN.
WATSON, ANALISI FARMACEUTICA, EDISES
KELLNER, MERMER, OTTO, WIDMER, CHIMICA ANALITICA, EDISES
COZZI, PROTTI, RUARO, ANALISI CHIMICA STRUMENTALE, ZANICHELLI
HARRIS D.C., CHIMICA ANALITICA QUANTITATIVA, ED. ZANICHELLI
PORRETTA G.C., ANALISI DI PREPARAZIONI FARMACEUTICHE, ED. CISU
-NOVELLINO E., MARSEGLIA S., IACCARINO C., ANALISI CHIMICO FARMACEUTICA QUANTITATIVA
ANALITICA, EDISES
COZZI, PROTTI, RUARO, ANALISI CHIMICA STRUMENTALE, ZANICHELLI
HARRIS D.C., CHIMICA ANALITICA QUANTITATIVA, ED. ZANICHELLI
PORRETTA G.C., ANALISI DI PREPARAZIONI FARMACEUTICHE, ED. CISU
NOVELLINO E., MARSEGLIA S., IACCARINO C., ANALISI CHIMICO FARMACEUTICA QUANTITATIVA

	More Information
	LANGUAGE ITALIAN, THE LESSONS WILL TAKE PLACE AT THE DEPARTMENT OF PHARMACY FOR FURTHER INFO PLEASE SEND EMAIL TO THE TEACHER: SMUSELLA@UNISA.IT

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VERONICA DI SARNO | ANALYSIS OF DRUGS 1